Author(s): Alok Kumar, Kanchan Singh, Kartik Kumar, Sachin Kumar, Arjun Singh

Email(s): arjunphar@gmail.com

DOI: 10.52711/0975-4377.2024.00017   

Address: Alok Kumar1, Kanchan Singh1, Kartik Kumar1, Sachin Kumar1, Arjun Singh2*, Alpesh Tripath1, Lakshya Tiwari1
1Department of Pharmacology, School of Pharmaceutical Sciences, Bhagwant University, Sikar Road, Ajmer, Rajasthan 305004, India.
2Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, United Statea.
*Corresponding Author

Published In:   Volume - 16,      Issue - 1,     Year - 2024


ABSTRACT:
Immunotherapy has revolutionized cancer treatment by leveraging the body's immune system to fight against cancer cells. This article provides an overview of immunotherapy, focusing on its different modalities, mechanisms of action, clinical applications, and the management of immune-related adverse events. Immune checkpoint inhibitors, such as PD-1 and CTLA-4 inhibitors, are prominent modalities that enhance the immune response by blocking regulatory proteins. Additionally, CAR-T therapy genetically modifies a patient's T cells to target specific proteins on cancer cells, leading to precise cancer cell elimination. Immunotherapy has demonstrated remarkable success in certain malignancies and offers new hope for patients battling cancer.


Cite this article:
Alok Kumar, Kanchan Singh, Kartik Kumar, Sachin Kumar, Arjun Singh. Immunotherapy in Cancer Treatment: Harnessing the Power of the Immune System. Research Journal of Pharmaceutical Dosage Forms and Technology.2024; 16(1):107-2. doi: 10.52711/0975-4377.2024.00017

Cite(Electronic):
Alok Kumar, Kanchan Singh, Kartik Kumar, Sachin Kumar, Arjun Singh. Immunotherapy in Cancer Treatment: Harnessing the Power of the Immune System. Research Journal of Pharmaceutical Dosage Forms and Technology.2024; 16(1):107-2. doi: 10.52711/0975-4377.2024.00017   Available on: https://rjpdft.com/AbstractView.aspx?PID=2024-16-1-17


REFERENCES:
1.    Nayna Abhang, Joe Lopez. Health Belief Model for Social Marketing of Breast Self-Examination – A Review of Literature. Asian Journal of Management. 2018; 9(1):493-499.
2.    Nirmala V., Athahari Begu, Anuradha. Effectiveness of Video Assisted Teaching Programme on Prevention of Oral Cancer among Tobacco Chewers. Asian J. Nur. Edu. and Research. 2012; 2(2): 83-86.
3.    Somsubhra Ghosh, Arnab Jana, Beduin Mahanti. An Updated Review on Medical Detection of Dog. Asian J. Pharm. Ana. 2016; 6(1): 47-52.
4.    Ch. Prudhvi Raju, G. Raveendra Babu, M. Sowjanya, M. Ramayyappa. Evaluation of Cancer Bio-markers through Hyphenated Analytical Techniques. Asian Journal of Pharmaceutical Analysis. 2021; 11(3):235-2.
5.    T. Angel Priya, N. Ganapathy, P. Padmavathi. Guided Imagery on Bio Physiological Parameters among Patients receiving Chemotherapy. Asian J. Nursing Education and Research. 2018; 8(3): 437-439.
6.    Moses. K, P. Karthika, Najarana Patel. Awareness regarding Cervical Cancer among Married Women. Asian J. Nursing Education and Research. 2018; 8(4):515-518.
7.    Somsubhra Ghosh, Arnab Jana, Beduin Mahanti. An Updated Review on Medical Detection of Dog. Asian J. Pharm. Ana. 2016; 6(1): 47-52.
8.    Kritika Sharma, Raman Kalia, Manpreet, Shaveta Sharma. A Descriptive Study to Assess the Health Profile and Warning Signs of Cancer among adults Residing in Selected Rural areas of District Roopnagar Punjab. Asian J. Nursing Education and Research. 2018; 8(3):371-374.
9.    Srivastava, Ankita, Kaneez Fatima, Eram Fatima, Arjun Singh, Aastha Singh, Aparna Shukla, Suaib Luqman, et al. Fluorinated Benzylidene Indanone Exhibits Antiproliferative Activity through Modulation of Microtubule Dynamics and Antiangiogenic Activity. European Journal of Pharmaceutical Sciences. 2020;  154(1): 105513. https://doi.org/10.1016/j.ejps.2020.105513.
10.    Singh, Aastha, Fatima, K., Srivastava, A., Khwaja, S., Priya, D., Singh, Arjun, Mahajan, G., Alam, S., Saxena, A.K., Mondhe, D.M., Luqman, S., Chanda, D., Khan, F., Negi, A.S. Anticancer activity of gallic acid template-based benzylidene indanone derivative as microtubule destabilizer. Chem Biol Drug Des.2016; 88: 625–634.
11.    Gautam, Yashveer, Sonam Dwivedi, Ankita Srivastava, Hamidullah, Arjun Singh, D. Chanda, Jyotsna Singh, Smita Rai, Rituraj Konwar, and Arvind S. Negi. 2-(3′,4′-Dimethoxybenzylidene)Tetralone Induces Anti-Breast Cancer Activity through Microtubule Stabilization and Activation of Reactive Oxygen Species. RSC Advances. 2016; 6(40):: 33369–79. https://doi.org/10.1039/C6RA02663J.
12.    Hamid, A.A., Mohammad Hasanain, Arjun Singh, Balakishan Bhukya, Omprakash, Prema G. Vasudev, Jayanta Sarkar, et al. Synthesis of Novel Anticancer Agents through Opening of Spiroacetal Ring of Diosgenin. Steroids. 2014;  87: 108–18. https://doi.org/10.1016/j.steroids.2014.05.025.
13.    Jain, Shilpi, Arjun Singh, Puja Khare, D. Chanda, Disha Mishra, Karuna Shanker, and Tanmoy Karak. Toxicity Assessment of Bacopa Monnieri L. Grown in Biochar Amended Extremely Acidic Coal Mine Spoils. Ecological Engineering. 2017; 108: 211–19. https://doi.org/10.1016/j.ecoleng.2017.08.039.
14.    S. Lavanya, Nalini Jeyavantha Santha, Gowri Sethu. A descriptive study to assess the level of stress among women with selected type of cancer in Erode Cancer Centre at Erode. Asian J. Nur. Edu. & Research. 2014; 4(3): 321-324.
15.    Kumar, Balagani Sathish, Kusumoori Ravi, Amit Kumar Verma, Kaneez Fatima, Mohammad Hasanain, Arjun Singh, Jayanta Sarkar, Suaib Luqman, Debabrata Chanda, and Arvind S. Negi. Synthesis of Pharmacologically Important Naphthoquinones and Anticancer Activity of 2-Benzyllawsone through DNA Topoisomerase-II Inhibition. Bioorganic & Medicinal Chemistry. 2017; 25(4): 1364–73. https://doi.org/10.1016/j.bmc.2016.12.043.
16.    Mishra, Disha, Jyotshna, Arjun Singh, D. Chanda, K. Shanker, and Puja Khare. Potential of Di-Aldehyde Cellulose for Sustained Release of Oxytetracycline: A Pharmacokinetic Study. International Journal of Biological Macromolecules. 2019; 136: 97–105. https://doi.org/10.1016/j.ijbiomac.2019.06.043.
17.    Sathish Kumar, B., Aastha Singh, Amit Kumar, Jyotsna Singh, Mohammad Hasanain, Arjun Singh, Nusrat Masood, et al. Synthesis of Neolignans as Microtubule Stabilisers. Bioorganic & Medicinal Chemistry. 2014; 22(4): 1342–54. https://doi.org/10.1016/j.bmc.2013.12.067.
18.    Singh, Arjun, Ipsita Mohanty, Jagmohan Singh, and Satish Rattan. BDNF Augments Rat Internal Anal Sphincter Smooth Muscle Tone via RhoA/ROCK Signaling and Nonadrenergic Noncholinergic Relaxation via Increased NO Release. American Journal of Physiology-Gastrointestinal and Liver Physiology. 2020; 318(1): G23–33. https://doi.org/10.1152/ajpgi.00247.2019.
19.    Singh, Arjun, and Satish Rattan. BDNF Rescues Aging-Associated Internal Anal Sphincter Dysfunction. American Journal of Physiology-Gastrointestinal and Liver Physiology. 2021; 321(1): G87–97. https://doi.org/10.1152/ajpgi.00090.2021.
20.    Singh, Arjun, Jagmohan Singh, and Satish Rattan. “Evidence for the Presence and Release of BDNF in the Neuronal and Non‐neuronal Structures of the Internal Anal Sphincter.” Neurogastroenterology and Motility. 2021. https://doi.org/10.1111/nmo.14099.
21.    Ravi Barot, T. Sivabalan. A study to evaluate the Quality of life in Head and Neck Cancer Patients admitted in Pravara Rural Hospital, Loni (Bk). Asian J. Nur. Edu. and Research. 2013; 3(1): 21-24.
22.    Manmohan, S., Arjun, S., Khan, S. P., Eram, S., and Sachan, N. K.   Green chemistry potential for past, present and future perspectives. International Research Journal of Pharmacy. 2012; 3: 31-36.
23.    Singh A, Kumar BS, Alam S, Iqbal H, Shafiq M, Khan F, Negi AS, Hanif K, Chanda D. Corrigendum to "Diethyl-4,4'-dihydroxy-8,3'-neolign-7,7'-dien-9,9'-dionate exhibits AH activity in rats through increase in intracellular cGMP level and blockade of calcium channels" [Eur. J. Pharmacol. 799 (2017) 84-93]. Eur J Pharmacol. 2017 Jul 5;806:111. doi: 10.1016/j.ejphar.2017.04.033. Erratum for: Eur J Pharmacol. 2017 Mar 15;799:84-93. PMID: 28495016.
24.    Singh, A., R. Sharma, K. M. Anand, S. P. Khan, and N. K. Sachan. Food-drug interaction. International Journal of Pharmaceutical & Chemical Science. 2012; 1(1): 264-279.
25.    Arjun Singh. A Review of various aspects of the Ethnopharmacological, Phytochemical, Pharmacognostical, and Clinical significance of selected Medicinal plants. Asian Journal of Pharmacy and Technology. 2022; 12(4): 349-0. doi: 10.52711/2231-5713.2022.00055
26.    Sampoornam. W. Hermeneutic circle focusing lived experience of Breast Cancer Survivorship- A Phenomenological Approach. Asian J. Nur. Edu. and Research. 2015; 5(3): 439-442.
27.    Jisa George T, Kiran Batra. Cancer cervix; Preventive strategies; Pap smear screening. Asian J. Nur. Edu. and Research. 2015; 5(3): 420-424.
28.    Bhagya Seela S, Shanmuga Raju P, Ezhilarasi R. Role of Nursing in Lymphoedema with Breast Cancer Patients. Asian J. Nur. Edu. and Research. 2015; 5(4): 542-544.
29.    Jisa George T, Kiran Batra. Beliefs and Attitude of Women Regarding Cervical Cancer Prevention and Screening in a Rural Community of Kerala. Asian J. Nur. Edu. and Research. 2016; 6(1): 7-10.
30.    Arjun Singh. A Review of various aspects of the Ethnopharmacological, Phytochemical, Pharmacognostical, and Clinical significance of selected Medicinal plants. Asian Journal of Pharmacy and Technology. 2022; 12(4): 349-0. doi: 10.52711/2231-5713.2022.00055  
31.    Devender Paswan, Urmila Pande, Alka Singh, Divya Sharma, Shivani Kumar, Arjun Singh. Epidemiology, Genomic Organization, and Life Cycle of SARS CoV-2. Asian Journal of Nursing Education and Research. 2023; 13(2):141-4.  
32.    Arjun Singh. A Review of various aspects of the Ethnopharmacological, Phytochemical, Pharmacognostical, and Clinical significance of selected Medicinal plants. Asian Journal of Pharmacy and Technology. 2022; 12(4):349-0.
33.    Arjun Singh, Rupendra Kumar. An Overview on Ethnopharmacological, Phytochemical, and Clinical Significance of Selected Dietary Polyphenols. Asian Journal of Research in Chemistry. 2023; 16(1):8-2.
34.    Arjun Singh. Plant-based Isoquinoline Alkaloids: A Chemical and Pharmacological Profile of Some Important Leads. Asian Journal of Research in Chemistry. 2023; 16(1): 43-8.  
35.    Singh, A., Chanda, D., and Negi, A. S. Antihypertensive activity of Diethyl-4, 4'-dihydroxy-8, 3'-neolign-7, 7'-dien-9, 9'-dionate through increase in intracellular cGMP level and blockade of calcium channels (VDCC) and opening of potassium channel and in vivo models (SHRs and L-NAME induced hypertension). In Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018 (The 18th World Congress of Basic and Clinical Pharmacology) (pp. PO1-2). Japanese Pharmacological Society.  
36.    Arjun Singh, Rupendra Kumar, Sachin Sharma. Natural products and Hypertension: Scope and role in Antihypertensive Therapy. Asian Journal of Nursing Education and Research. 2023; 13(2): 162-6.  
37.    Pumila Singh, Divya Sharma, Varsha Singh, Sheila Kumari, Arjun Singh, Hema Jain. Management of Non-hospitalized patients with Acute SARS-CoV-2 (COVID-19) viral infection in among human adult population. Asian Journal of Management. 2023; 14(4): 227-2. doi: 10.52711/2321-5763.2023.00038
38.    Arjun Singh. Withania somnifera (L.) Ashwagandha: A Review on Ethnopharmacology, Phytochemistry, Biomedicinal and Traditional uses. Asian Journal of Pharmacy and Technology. 2023; 13(3): 213-7. doi: 10.52711/2231-5713.2023.00038
39.    Arjun Singh. An Overview on Phytoestrogen based antihypertensive agent for their potential Pharmacological Mechanism. Research Journal of Pharmaceutical Dosage Forms and Technology. 2023; 15(3): 211-4. doi: 10.52711/0975-4377.2023.00034
40.    Arjun Singh, Rupendra Kumar, Sachin Sharma. Natural products and Hypertension: Scope and role in Antihypertensive Therapy. Asian Journal of Nursing Education and Research. 2023; 13(2): 162-6. doi: 10.52711/2349-2996.2023.00035
41.    Kaman Kumar, Pooja Singh, Divya Sharma, Akanksha Singh, Himanshu Gupta, Arjun Singh. Prospective Current Novel Drug Target for the Identification of Natural Therapeutic Targets for Alzheimer's Disease. Asian Journal of Pharmacy and Technology. 2023; 13(3): 171-4. doi: 10.52711/2231-5713.2023.00030
42.    Singh, A. (2023). Brain-derived neurotrophic factor – a key player in the gastrointestinal system. Gastroenterology Review/Przegląd Gastroenterologiczny, 18(4), 380-392. https://doi.org/10.5114/pg.2023.132957
43.    Devender Paswan, Urmila Pande, Alka Singh, Divya Sharma, Shivani Kumar, Arjun Singh. Epidemiology, Genomic Organization, and Life Cycle of SARS CoV-2. Asian Journal of Nursing Education and Research. 2023; 13(2):141-4. doi: 10.52711/2349-2996.2023.00031
44.    Arjun Singh. Plant-based Isoquinoline Alkaloids: A Chemical and Pharmacological Profile of Some Important Leads. Asian Journal of Research in Chemistry. 2023; 16(1):43-8. doi: 10.52711/0974-4150.2023.00008



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