Author(s):
Shaikh Muzammil Shaikh Laal, S.A. Bhagat, Sayyad Toufik Agamiyan, S.B. Jadhav, V.V. Navghare
Email(s):
sshaikhmuzammil20@gmail.com
DOI:
10.52711/0975-4377.2026.00039 
Address:
Shaikh Muzammil Shaikh Laal1*, S.A. Bhagat2, Sayyad Toufik Agamiyan3, S.B. Jadhav4, V.V. Navghare5
1,3Research Scholar, Department of Pharmaceutics, Indira College of Pharmacy, Vishnupuri, Nanded, Maharashtra Pin: 431606, India.
2,4,5Assistant Professor, Department of Pharmaceutics, Indira College of Pharmacy, Vishnupuri, Nanded, Maharashtra Pin: 431606, India.
*Corresponding Author
Published In:
Volume - 18,
Issue - 4,
Year - 2026
ABSTRACT:
The present research work focused on the formulation and evaluation of Meloxicam transdermal patches for sustained drug delivery in the treatment of inflammatory conditions and pain. Meloxicam, a non-steroidal anti-inflammatory drug (NSAID), is associated with gastrointestinal irritation and first-pass metabolism following oral administration. To overcome these limitations, transdermal patches were prepared by the solvent casting method using varying ratios of HPMC K15M and Ethyl Cellulose along with PEG 400, glycerin, and oleic acid. FTIR studies confirmed the compatibility of Meloxicam with the selected excipients. Six formulations (F1–F6) were prepared and evaluated for physicochemical parameters such as thickness, weight variation, drug content, folding endurance, surface pH, swelling index, and in vitro drug release. All formulations showed smooth and uniform films with satisfactory mechanical properties and drug distribution. Drug content ranged from 97.85 ± 1.18% to 99.68 ± 0.98%. The surface pH was near neutral, indicating suitability for skin application. The in vitro drug release study demonstrated that the polymer ratio significantly affected drug release behavior. Among all formulations, F5 was identified as the optimized batch, showing 98.85 ± 1.60% cumulative drug release over 24 hours with sustained release characteristics. Drug release kinetics revealed that F5 best fitted the Higuchi model, indicating diffusion-controlled drug release. Stability studies confirmed the physical and chemical stability of the optimized formulation under accelerated conditions. The study concluded that, the developed Meloxicam transdermal patches, particularly formulation F5, exhibited satisfactory physicochemical properties, sustained drug release, and good stability, indicating their potential as an effective transdermal drug delivery system.
Cite this article:
Shaikh Muzammil Shaikh Laal, S.A. Bhagat, Sayyad Toufik Agamiyan, S.B. Jadhav, V.V. Navghare. Formulation and Evaluation of Transdermal Patches of Meloxicam. Research Journal of Pharmaceutical Dosage Forms and Technology. 2026; 18(4):287-0. doi: 10.52711/0975-4377.2026.00039
Cite(Electronic):
Shaikh Muzammil Shaikh Laal, S.A. Bhagat, Sayyad Toufik Agamiyan, S.B. Jadhav, V.V. Navghare. Formulation and Evaluation of Transdermal Patches of Meloxicam. Research Journal of Pharmaceutical Dosage Forms and Technology. 2026; 18(4):287-0. doi: 10.52711/0975-4377.2026.00039 Available on: https://rjpdft.com/AbstractView.aspx?PID=2026-18-4-1
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