Research Journal of Pharmaceutical Dosage Forms and Technology

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0975-4377 (Online)
0975-234X (Print)


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Formulation and In-Vitro Evaluation of a Sustained Release Matrix Tablet of Telmisatan

Author(s): Hamid Khan, Javed Ali

Email(s): khanhamid770@gmail.com

DOI: 10.5958/0975-4377.2017.00004.0   

Address: Hamid Khan1*, Javed Ali2
1Associate Professor, JK College of Pharmacy, Bilaspur, CG, India-495001
2Department of Pharmaceutics, Faculty of Pharmacy, Hamdard University, New Delhi, India-110062
*Corresponding Author

Published In:   Volume - 9,      Issue - 1,     Year - 2017

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ABSTRACT:
The formulation and in-vitro evaluation of matrix tablets containing telmisartan as sustained release using low viscosity grade HPMC as the matrix forming hydrophilic polymer by wet granulation method. The tablets were subjected to in-vitro drug release study in hydrochloric acid buffer of pH 1.2 (0.1N) with 1% w/v SLS using USP paddle apparatus. The drug released at various time intervals were determined by validated UPLC-PDA method. The prepared tablets showed better sustained release effect when compared with marketed tablets. The drug release mechanism from hydrophilic polymer was proposed. The formulated tablets provided sustained release of telmisartan over a period of 24 h.


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Cite this article:
Hamid Khan, Javed Ali. Formulation and In-Vitro Evaluation of a Sustained Release Matrix Tablet of Telmisatan. Res. J. Pharm. Dosage Form. & Tech. 9(1): Jan.-Mar. 2017; Page 19-23. doi: 10.5958/0975-4377.2017.00004.0


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Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

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DOI: 10.5958/0975-4377 

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Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. The aim of RJPDFT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPDFT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical Chemistry, Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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