Author(s): Susmitha. A, Narendra Babu. K, Imran Khan Pathan, Ishwarya. K

Email(s): susmi.july@gmail.com

DOI: Not Available

Address: Susmitha. A*, Narendra Babu. K, Imran Khan Pathan, Ishwarya. K
Department of Pharmaceutics, Arulmigu Kalasalingam College of Pharmacy, Tamilnadu, India
*Corresponding Author

Published In:   Volume - 6,      Issue - 3,     Year - 2014


ABSTRACT:
The present investigation was to develop immediate release (IR) tablet formulations of Capecitabine an anti-cancer drug, using Hydroxy Propyl Methyl Cellulose (HPMC E5) as binding agent. The tablets were prepared by wet granulation process and evaluated for various physico-chemical/mechanical parameters. Among the formulations the optimised formulation was identified by comparing dissolution profiles with innovator. The formulation containing 97.5mg MCC (Avicel PH 101) as filler and 20mg HPMC E5 as binder gave a bioequivalent dissolution profile as innovator over a period of 60min (100.8 %). The dissolution data of optimized formulation was also evaluated for drug release kinetics and mechanisms. The significant factor for optimised formulation and innovator was evaluated.


Cite this article:
Susmitha. A, Narendra Babu. K, Imran Khan Pathan, Ishwarya. K . Formulation and Evaluation of Capecitabine Immediate Release Tablets. Res. J. Pharm. Dosage Form. and Tech. 6(3):July- Sept. 2014; Page 212-217.


Recomonded Articles:

Author(s): Patil Namrata D., Gondkar S.B., Saudagar R.B.

DOI: 10.5958/0975-4377.2016.00033.1         Access: Open Access Read More

Author(s): Debjit Bhowmik, Amrendra Singh , Praveen Khirwadkar, Nishi Shukla, Vikas Kumar Chaudhari

DOI: 10.5958/0975-4377.2016.00027.6         Access: Open Access Read More

Author(s): Masheer Ahmed Khan

DOI:         Access: Open Access Read More

Author(s): Sawant VA, Jayprabha P, Shende VS, Borkar SN, Wakale VS, Deore SR, Dame GY, Barve AO, Chatap VK

DOI:         Access: Open Access Read More

Author(s): V Ganesan, Nilesh P Tekade, Nitin S Bhajipale, Durgesh R Dewade, Raju R Thenge

DOI:         Access: Open Access Read More

Author(s): Swati Rawat, Shradha Sangali, Akhilesh Gupta

DOI: 10.5958/0975-4377.2018.00001.0         Access: Open Access Read More

Author(s): AL. Akilandeshwari , K. Elango, S. Daisy Chellakumari, S. Kishore Kumar

DOI:         Access: Open Access Read More

Author(s): Suresh A. Marnoor

DOI:         Access: Open Access Read More

Author(s): Sachin N. Kothawade, Ashwini Ishware, Priyanka Darekar, Amit S. Lunkad

DOI:         Access: Open Access Read More

Author(s): Viswanadham Manasa, K.Vanitha, M. Venkataswamy, P. Prabhakar, Alluri Ramesh

DOI: 10.5958/0975-4377.2016.00002.1         Access: Open Access Read More

Author(s): Doppalapudi Sandeep, A. P. Pratyusha, G. Sudheshna, K. Lakshmi prasanna, P. Sreekanth

DOI:         Access: Open Access Read More

Author(s): Amit K. Jain, Rajput Rammulrajsinh, Pradeep Agrawal, Kinal patel

DOI:         Access: Open Access Read More

Author(s): Bhoyar PK, Biyani DM, Shahare HV, Ikhar PK,Borkar VS

DOI:         Access: Open Access Read More

Author(s): Chinmaya Keshari Sahoo, Surepalli Ram Mohan Rao, Muvvala Sudhakar

DOI: 10.5958/0975-4377.2017.00020.9         Access: Open Access Read More

Author(s): Sonia Singh, Umesh D. Shivhare, S. N. Sakarkar

DOI:         Access: Open Access Read More

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0975-4377 


Recent Articles




Tags