Author(s): Bharadhan Bose, Koteeswaran Kannan

Email(s): b.barani143@gmail.com

DOI: 10.52711/0975-4377.2025.00032   

Address: Bharadhan Bose1,2*, Koteeswaran Kannan2
1Sree Abirami College of Pharmacy, Coimbatore - 641021, Tamil Nadu, India. (Affiliated with The Tamil Nadu Dr. M. G. R. Medical University, Chennai).
2Sankaralingam Bhuvaneswari College of Pharmacy, Virudhunagar - 626130, Tamil Nadu, India. (Affiliated with The Tamil Nadu Dr. M. G. R. Medical University, Chennai).
*Corresponding Author

Published In:   Volume - 17,      Issue - 4,     Year - 2025


ABSTRACT:
Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) is considered as major life-threatening disease and dangerous to human population worldwide. The symptoms are related with upper and lower respiratory tracts like cough, fever and headache are visualized during viral infection and at last fatal if condition remains chronic more than 10 days. AYUSH (Ayurveda, Yoga, Unani, Siddha and Homeopathy) and WHO (World Health Organization) recommended Kabasura Chooranam (KC), a polyherbal formulation which contains 15 potent medicinal property containing phyto powders, plays a vital role in targeting SARS-CoV-2 and their pathway. The KC is consumed by infusing the powder in water and making it as decoction. Administration of KC in the form of oral liquids is a convenient method, but in some instances, during the time of infection patient might be in isolation at that time preparation of liquid from powders is quite difficult also it require heat for doing the preparation. Hence it requires people assistance and there may be a risk to spread the virus to the people surroundings. Degradation of KC aqueous extract on prolonged time storage may produce instability. It has higher chance of dose variability since the delivery of the dose depends upon the patient measuring the proper volume. The taste is usually unpleasant is always more prominent when in solution than in a solid form. For increasing stability time, producing fast actions, consuming required dose and masking bitter taste, an attempt of oral dispersible tablet has been developed. The main objective of this study is to overcome the dyspepsia in pediatric, geriatric and sickly affected patients by formulating a polyherbal oral dispersible tablet for the management, treatment and to boost immune response against COVID-19 virus.


Cite this article:
Bharadhan Bose, Koteeswaran Kannan. Development of Combinatorial Aqueous Herbal Extract Loaded Orodispersible Tablets for the Prevention and Treatment of COVID-19. Research Journal of Pharmaceutical Dosage Forms and Technology. 2025; 17(4):231-8. doi: 10.52711/0975-4377.2025.00032

Cite(Electronic):
Bharadhan Bose, Koteeswaran Kannan. Development of Combinatorial Aqueous Herbal Extract Loaded Orodispersible Tablets for the Prevention and Treatment of COVID-19. Research Journal of Pharmaceutical Dosage Forms and Technology. 2025; 17(4):231-8. doi: 10.52711/0975-4377.2025.00032   Available on: https://rjpdft.com/AbstractView.aspx?PID=2025-17-4-2


8. REFERENCES:
1.    Hankey A. Ayurveda and the battle against chronic disease: an opportunity for ayurveda to go mainstream. J Ayurveda Integ Med. 2010; 1:9–12.
2.    Chaudhary A, Singh N. Contribution of world health organization in the global acceptance of ayurveda. J Ayurveda Integ Med. 2011; 2: 179–86.
3.    KJ R. Sherris medical microbiology: An introduction to infectious diseases. Norwalk: Appleton and Lange. 1994.
4.    Li G, Fan Y, Lai Y, Han T, Li Z, Zhou P, et al. Coronavirus infections and immune responses. J Med Viro. 2020 Apr 7; 92(4): 424–32. https://onlinelibrary.wiley.com/doi/10.1002/jmv.25685
5.    M.J. Moshi, P.P. Mhame. Legislation on Medicinal Plants in Africa. In Medicinal Plant Research in Africa; Elsevier, 2013; pp 843–858. https://doi.org/10.1016/B978-0-12-405927-6.00023-0
6.    M.M. Al-Ansari, A.J.A. Ranjit Singh, F.S. Al-Khattaf, J.S. Michael. Nano-formulation of herbo-mineral alternative medicine from Linga chenduram and evaluation of antiviral efficacy. Saudi J. Biol. Sci. 2021; 28(3): 1596–1606. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7938193/
7.    M. Modak, P. Dixit, J. Londhe, S. Ghaskadbi, T.P.A. Devasagayam. Indian Herbs and Herbal Drugs Used for the Treatment of Diabetes. J. Clin. Biochem. Nutr. 2007; 40(3): 163–173.https://www.jstage.jst.go.jp/article/jcbn/40/3/40_3_163/_article
8.    Ghorbani, R. Shafiee-Nick, H. Rakhshandeh, A. Borji. Antihyperlipidemic Effect of a Polyherbal Mixture in Streptozotocin-Induced Diabetic Rats. J. Lipids 2013; 1–6. https://doi.org/10.1155/2013/675759
9.    Pandey MM, Rastogi S, Rawat AKS. Indian traditional Ayurvedic system of medicine and nutritional supplementation. J Evidence Based Complementary Altern Med 2013: 1–12.  http://dx.doi.org/10.1155/2013/376327
10.    Garg V, Dhar VJ, Sharma A, Dutt R. Facts about standardization of herbal medicine: a review. Zhong Xi Yi Jie He Xue Bao. 2012; 10: 1077-83.
11.    Awasthi H, Mani D, Nath R, Nischal A, Usman K, Khattri S. Standardization, preparation and evaluation of an Ayurvedic polyherbal formulation in a capsule dosage form suitable for use in clinical trials. Indo Am J Pharm Res. 2014; 4: 4093-9.
12.    Mathew L, Babu S. Phytotherapy in India: the transition of tradition to technology. Curr Bot. 2011; 2:17–22.
13.    Siddha formulary of India Part II, The controller of Publications, Delhi. 2011; 160,173,178, 179,181-183,186,187,191,192.
14.    Raghaendra RNG, Ketan T, Sumanji B. Formulation and evaluation of fast dissolving tablet of metoprolol tartrate. Int J Pharm Clin Res. 2010; 2: 40–5.
15.    Sreenivas SA, Dandagi PM, Gadad AP, Godbole AM, Hiremath SP, Mastiholimath VS, et al. Orodispersible tablets: new-fangled drug delivery system - a review. Ind J Pharm Educ Res. 2005; 39: 177–80.
16.    Setty CM, Prasad DV, Gupta VRM. Development of fast dispersible acelofenac tablets: effect of functionality of superdisintegrants. Ind J Pharma Sci. 2008; 70:180–5.
17.    Karthikeyan M, Mukhthar UAK, Megha M, Shadeer HP. Formulation of diclofenac tablets for rapid pain relief. Asia Pacific J Trop Dis. 2012; 2(Suppl): S308–11.
18.    Shweta SG, Tapar KK, Borse MD, Ghuge RA. Taste masking and characterization of diphenhydramine hydrochloride by spray-drying technique. Int J Pharm Res Dev. 2010; 1:17.
19.    Anupama K, Shelly K, Neena B. Formulation and evaluation of mouth dissolving tablets of oxcarbazepine. Intl J Pharm Sci. 2009; 1:12–23.
20.    Govt. of India WHO Quality Control Methods for Medicinal plant Materials, 1998. Geneva: 10-31, 45, 46.
21.    Mukherjee PK. Quality Control of Herbal drugs: An approach to evaluation of botanicals. 1st edn, 2002; Business Horizons Pharmaceutical Publishers, Kolkata, pp- 132, 133, 161, 173, 177, 186, 214, 287,288.
22.    Batra Neha, Jain Honey, Bairwa Ranjan, Bachwani Mukesh. Pharmacognostical and preliminary phytochemical investigation of Acorus calamus linn. Asian J. Pharm. Res. 2012; 2(1): 39-42.  https://asianjpr.com/AbstractView.aspx?PID=2012-2-1-6
23.    N. Singh, M. Nandi, P. Pal. Detoxification of Croton tiglium L. seeds by Ayurvedic process of Śodhana. Anc. Sci. Life. 2014; 33 (3): 155. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4264303/ 
24.    Bhargava S, Dhabhai K, Batra A, et al. Zingiber Officinale: chemical and phytochemical screening and evaluation of its antimicrobial activities. J Chem Pharm Res. 2012; 1: 360-364.
25.    Mishra US, Murthy PN, Pasa G, Mishra D. Formulation development and evaluation of herbal tablet containing methanolic extract of Butea frondosa. Int J Inst Pharm Life Sci. 2011; 1: 1–15.
26.    United States Pharmacopoeia 30/NF25. Asian edition, The official compendia of standard United States Pharmacopoeia. Rockville, MD: Convection Inc. 2007; 277: 644–45.
27.    Mishra US, Murthy PN, Pasa G, Mishra D. Formulation development and evaluation of herbal tablet containing methanolic extract of Butea frondosa. Int J Inst Pharm Life Sci 2011; 1:1–15.
28.    Christianah I, Ekere K, Judith O, Olayemi O, Darlington O, et al. Phytopharmaceutical properties of herbal teas circulating in the Nigerian market. Afr J Pharm Pharmacol. 2016; 10: 1007–13.
29.    M. Attimarad, K.K. Mueen Ahmed, B.E. Aldhubaib, S. Harsha. High-performance thin layer chromatography: A powerful analytical technique in pharmaceutical drug discovery. Pharm. Methods. 2011; 2(2): 71–75. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658041/
30.    Chamarthi H. Formulation and evaluation of Orodispersible tablet of escitalopram oxalate by super disintegrants addition method. Int J Pharm Res Dev. 2011; 3: 65–72.
31.    Paul Y, Tyagi S, Singh B. Formulation and evaluation of oral dispersible tablets of zidovudine with different superdisintegrants. Int J Curr Pharm Rev Res. 2011; 2: 81–91.
32.    Prajapati BG, Patel B. Formulation, evaluation and optimization of orally disintegrating tablet of piroxicam. Int J Pharm Tech Res. 2010; 2:1893–9.
33.    R. Sheshala, N. Khan, Y. Darwis. Formulation and Optimization of Orally Disintegrating Tablets of Sumatriptan Succinate. Chem. Pharm. Bull. 2011; 59 (8): 920–928. https://pubmed.ncbi.nlm.nih.gov/21804234/
34.    H. Sohi, Y. Sultana, R.K. Khar. Taste Masking Technologies in Oral Pharmaceuticals: Recent Developments and Approaches. Drug Dev. Ind. Pharm. 2004; 30 (5): 429–448. https://pubmed.ncbi.nlm.nih.gov/15244079/
35.    Harshal Pawar, Chhaya Varkhade, Pravin Jadhav, Kavita Mehra, Development and evaluation of orodispersible tablets using a natural polysaccharide isolated from Cassia tora seeds. Integrative Medicine Research, 2014; 3(2):91-98, ISSN 2213-4220, https://doi.org/10.1016/j.imr.2014.03.002.
36.    Bunaciu AA, Aboul-Enein HY, Fleschin S. Recent applications of Fourier transform infrared spectrophotometry in herbal medicine analysis. Appl Spectro Rev. 2011; 46:251-60.
37.    Kumar PP, Pillai S, Michael M, Kavya K, Kumar P, Iqbal SS, et al. Fourier transform infrared (FT-IR) spectral studies of a novel polyherbal formulation of anti-obesity drug. J Med Sci-Tech. 2015; 4:55–7.
38.    Guidance for industry, ICH topic Q1A (R2) stability testing of new drug substances and products. Eur Med Agency (EMEA). 2003; CPMP/ICH/2736/99.

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