Author(s):
Gagan Kukloria, Kavita Savkare, Sonam Kukloria, Sujit Pillai
Email(s):
gagankukloria1110@gmail.com
DOI:
10.52711/0975-4377.2025.00025
Address:
Gagan Kukloria*, Kavita Savkare, Sonam Kukloria, Sujit Pillai
Department of Pharmaceutics, GRY Institute of Pharmacy, Khargone M.P.
*Corresponding Author
Published In:
Volume - 17,
Issue - 3,
Year - 2025
ABSTRACT:
In order to increase the drug's bioavailability, the work's goal was to create Sesamol-loaded microspheres using chitosan and sodium alginate as a polymeric matrix. Using different amounts of chitosan and a set concentration of sodium alginate, the microspheres were created using the ionic gelation process. The prepared microspheres were characterized by entrapment efficiency, particle size, in vitro drug release, scanning electron microscopy (SEM), and FT-IR. The in vitro drug released ranged from 94.36 to 98 % from the microsphere formulations at the end of 12 hours of the study. The formulations' average particle sizes varied from 29.88 ± 18.14 µm to 35.36 ± 16.37 µm. The microsphere formulations' drug contents varied from 67.45 to 89.71%. The developed microspheres indicated prolong drug release 12 hrs. The optimized batch F4. According to results of research Sesamol loaded microspheres sodium alginate and chitosan as polymeric matrix to improve bioavailability of the drug.
Cite this article:
Gagan Kukloria, Kavita Savkare, Sonam Kukloria, Sujit Pillai. Formulation and Characterization of Polymeric Microspheres Loaded with Sesamol for Improving Bioavailability. Research Journal of Pharmaceutical Dosage Forms and Technology.2025; 17(3):179-2. doi: 10.52711/0975-4377.2025.00025
Cite(Electronic):
Gagan Kukloria, Kavita Savkare, Sonam Kukloria, Sujit Pillai. Formulation and Characterization of Polymeric Microspheres Loaded with Sesamol for Improving Bioavailability. Research Journal of Pharmaceutical Dosage Forms and Technology.2025; 17(3):179-2. doi: 10.52711/0975-4377.2025.00025 Available on: https://rjpdft.com/AbstractView.aspx?PID=2025-17-3-3
REFERENCES:
1. Alagusundaram M, Madhu Sudana Chetty C, Umashankari K, Attuluri VB, Lavanya C, Ramkanth S. Microspheres as novel drug delivery system- a review. International Journal of ChemTech Research. 2009; 1: 526-534.
2. Luo X, Tang KY, Wang YY. Preparation of drug-loaded chitosan microspheres repair materials. European Review for Medical and Pharmacological Sciences. 2023; 27: 6489-6495.
3. Chowdary KPR, Srinivas L. Mucoadhesive drug delivery systems; A Review of Current status. Indian Drugs. 2000; 37(9): 400−406.
4. Mutalik S, Naha A,. Usha AN,. Ranjith AK, Musmade P, Manoj K, Anju P and Prasanna S. Preparation, In-vitro, Preclinical and Clinical Evaluations of Once Daily Sustained Release Tablets of Aceclofenac. Arch Pharm Res. 2007; 30(2): 222-234.
5. Patil S.S., Surawase, R. Kothawade P. Formulation Development and Evaluation of Floating Microspheres of Curcumin. Research Journal of Pharmaceutical Dosage Forms and Technology. 2023; 15(4): 275-0. doi: 10.52711/0975-4377.2023.00044.
6. Kadam PV, Yadav KN, Bhingare CL, Patil MJ. Standardization and quantification of curcumin from Curcuma longa extract using UV visible spectroscopy and HPLC. Journal of Pharmacognosy and Phytochemistry. 2018; 7(5):1913-8.
7. Amiruddin, Rijal MAS, Hariyadi DM” Effect of CaCl2 Crosslinker Concentration on the Characteristics, Release and Stability of Ciprofloxacin HCl-Alginate-Carrageenan Microsphere. Pharmacy and Pharmaceutical Sciences Journal. 2023; 10(3): 312-323.
8. Karosiya SR, Vaidya VM, Bhajipale NS, Radke RS. Formulation and Evaluation of Gastroretentive Floating Microspheres loaded with Lamivudine. Journal of Drug Delivery and Therapeutics. 2022; 12(4-S): 17-22.
9. Goyal P, Gill S, Gupta UD, Rath G, Narang RK, Goyal AK. Development and characterization of rifampicin loaded floating microspheres. Artificial Cells, Blood Substitutes, and Biotechnology. 2011; 39(5): 330-4.
10. Kumar K, Rai AK. Development and evaluation of floating microspheres of curcumin. Tropical Journal of Pharmaceutical Research. 2012; 11(5): 713-9.