Author(s): Puja Saha, Pratik Swarup Das

Email(s): pujasahaps070@gmail.com

DOI: 10.5958/0975-4377.2017.00026.X   

Address: Puja Saha*, Pratik Swarup Das
Pharmacy Institute, Noida Institute of Engineering and Technology.
*Corresponding Author

Published In:   Volume - 9,      Issue - 4,     Year - 2017


ABSTRACT:
The aim of the present work is to develop the formulation and evaluate the buccal patches of aceclofenac for gingivitis using different mucoadhesive polymers such as hpmc 5cps, carbopol 934p, eudragit rl 100 in various combinations. Method: The buccal patches were prepared by solvent casting method. All the buccal formulations were subjected to preformulation and physical evaluation studies, in-vitro drug release and ex-vivo permeation studies. In-vitro drug release from the formulation was studied using buffer pH 6.8. Results: From in vitro studies formulation F6 and F7 were selected for mucoadhesive studies and ex vivo permeation studies using buffer Ph 6.8. After all studies, formulation F7 containing hpmc 5cps and eudragit rl 100 in the ratio (400 mg: 200 mg) was selected as optimized formulation and its muccoadhesive strength and exhibited optimum drug release. FTIR results showed no evidence of interaction between the drug and polymers. Conclusion: After evaluating the formulations it revealed that the drug content was within the limits. The results indicated that delivery of aceclofenac to the local drug delivery via the buccal route improve its bioavailability and also was found to be stable during stability studies conducted for 3 months as per ICH guidelines.


Cite this article:
Puja Saha, Pratik Swarup Das. Formulation Development and Evaluation of Buccal Patches of Aceclofenac for Gingivitis. Res. J. Pharm. Dosage Form. & Tech. 2017; 9(4): 163-167. doi: 10.5958/0975-4377.2017.00026.X


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DOI: 10.5958/0975-4377 


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