Domendra Sahu, Shekhar Verma, Ravindra D. Dubey
Domendra Sahu*, Shekhar Verma and Ravindra D. Dubey
Institute of Pharmacy, RITEE, Chhatauna, Mandir Hasaud, Raipur, Chhattisgarh, India.
Volume - 3,
Issue - 5,
Year - 2011
The attractiveness of these dosage forms is due to awareness to toxicity and ineffectiveness of drugs when administered or applied by conventional method in the form of tablets, capsules, injections, ointments etc. usually conventional dosage form produces wide ranging fluctuation in drug concentration in the blood stream and tissues with consequent undesirable toxicity and poor efficiency. These factors as well as factors such as repetitive dosing and unpredictable absorption lead to the concept of controlled delivery system. The goal in designing sustained or controlled delivery system is to reduce the frequency of the dosing or to increase effectiveness of the drug by localization at the site of action, reducing the dose required or providing uniform drug delivery. Tolperisone hydrochloride is a centrally acting muscle relaxant that has used for symptomatic treatment of spasticity and muscle pain, with half-life of 2.5-3 hours and requires multiple daily doses to maintain adequate plasma concentrations, so it is selected to prepare a sustained release tablets. The objective of this present study to develop a competitive sustained release tablets of Tolperisone Hydrochloride which releases the drug in a sustained manner over a period of 24 hours, by using different polymer and study on there effect on release pattern.
Cite this article:
Domendra Sahu, Shekhar Verma , Ravindra D. Dubey. Formulation and Evaluation of Tolperisone Hydrochloride Sustained Release Tablet. Research J. Pharma. Dosage Forms and Tech. 2011; 3(5): 220-224.