Research Journal of Pharmaceutical Dosage Forms and Technology

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0975-4377 (Online)
0975-234X (Print)


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Design, Development and Evaluation of Solifenacin Succinate Tablets

Author(s): R. K.V. Naga Sudha, V. Sai Kishore, CH. Venu Babu, E. Jitendranath

Email(s): nagasudharkv@gmail.com , voiceofsaikishore@yahoo.com pharmacistvenu@gmail.com , ejitendranath@gmail.com.

DOI: 10.5958/0975-4377.2015.00016.6   

Address: R. K.V. Naga Sudha1*, V. Sai Kishore1, CH. Venu Babu1, E. Jitendranath2
1Bapatla College of Pharmacy, Bapatla -522101,Guntur (District), Andhra Pradesh (state), India.
2AKRG College of Pharmacy, Vijayawada, A.P
*Corresponding Author

Published In:   Volume - 7,      Issue - 2,     Year - 2015

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ABSTRACT:
Solifenacin Succinate is used in the treatment of over active bladder with symptoms of urge urinary incontinence, urgency, and increased urinary frequency, and anti spasmodic. Solifenacin Succinate was launched in 2005 and has been shown in both short and long term clinical trials to fulfill these requirements. Solifenacin is a competitive M3 receptor antagonist with a long half-life (45-68 hours). It is available in two dosage strengths namely a 5 or 10 mg once-daily tablet. Ten different trial batches were carried out using different concentrations of excipients like binder (Methocel E5 premium LV), super disintegrant (sodium starch glycolate, cross carmellose sodium, cross povidone), lubricant (Magnesium stearate), glidant (Aerosil) by direct compression technique. The pre-compression parameters and post compression parameters of Solifenacin Succinate tablets were evaluated. The tablets were evaluated for in-vitro drug release studies. Based on similarity factor f2 cross povidone (1.17%), Methocel E5 premium LV (3%), Magnesium starate (1.47%), Aerosil (0.529%) was selected.


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Cite this article:
R. K.V. Naga Sudha, V. Sai Kishore, CH. Venu Babu, E. Jitendranath. Design, Development and Evaluation of Solifenacin Succinate Tablets. Res. J. Pharm. Dosage Form. & Tech. 7(2): April-June, 2015; Page 111-117. doi: 10.5958/0975-4377.2015.00016.6

Cite(Electronic):
R. K.V. Naga Sudha, V. Sai Kishore, CH. Venu Babu, E. Jitendranath. Design, Development and Evaluation of Solifenacin Succinate Tablets. Res. J. Pharm. Dosage Form. & Tech. 7(2): April-June, 2015; Page 111-117. doi: 10.5958/0975-4377.2015.00016.6   Available on: https://rjpdft.com/AbstractView.aspx?PID=2015-7-2-4


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Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. The aim of RJPDFT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPDFT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical Chemistry, Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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