Author(s): Omprasad Nayakal, Prajakta Patil, Mangesh Bhutkar, Dheeraj Randive, Somnath Bhinge

Email(s): omnayakal@gmail.com

DOI: 10.5958/0975-4377.2018.00032.0   

Address: Omprasad Nayakal*, Prajakta Patil, Mangesh Bhutkar, Dheeraj Randive, Somnath Bhinge
Rajarambapu College of Pharmacy, Kasegaon, Tal- Walwa. Dist- Sangli, Maharashtra -India 415404
*Corresponding Author

Published In:   Volume - 10,      Issue - 4,     Year - 2018


ABSTRACT:
The motto of the present research work was to develop fast dissolving tablets of Clopidogrel bisulfate by using Holy basil seeds mucilage as a natural super disintegrating agent. Clopidogrel is a thienopyridine with antiplatelet activity. It irreversibly alters the platelet receptor for adenosine diphosphate. To formulate fast dissolving tablets of Clopidogrel bisulfate direct compression technique was employed using 6,12 and 18 mg concentrations of Holy basil seed mucilage which acted as a natural super disintegrant. Also compatibility of the drug and Holy basil seed mucilage was studied by using FTIR study. The powdered Holy basil seeds were characterized for various parameters namely ash value, solubility and pH. The prepared tablets were evaluated by using various parameters. The results of weight variation test revealed that it was within the accepted limits. Thickness and hardness of the formulated tablets were between 2.6±0.25 to 3.1±0.32mm and 3.1±0.11 to 3.0±0.21 kg/cm2 for the prepared batches. Wetting time of the tablets was found to be between 22±0.54 to 35±0.57sec. The results of in-vitro disintegration time of the tablets varied from 32±1.2 to 40±1 sec. for the prepared batches. Formulation F3 comprising of Holy basil seed mucilage (30mg) was also compared F6, containing 30 mg of Crospovidone as super disintegrating agent. It was observed that the drug release from formulation F6 was 91.9% in 10min, whereas formulation F3 exhibited 99% drug release at the end of 10 minutes. Thus, it was concluded that Holy basil seed mucilage possess good potential of partly replacing the commercial superdisintegrant(s).


Cite this article:
Omprasad Nayakal, Prajakta Patil, Mangesh Bhutkar, Dheeraj Randive, Somnath Bhinge. Formulation and Evaluation of Fast Dissolving Tablets containing Clopidogrel bisulfate using holy basil seeds as a natural superdisintegrant. Res. J. Pharm. Dosage Form. and Tech. 2018; 10(4): 209-214. doi: 10.5958/0975-4377.2018.00032.0


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