Author(s): Suyash Ingle, Varsha Tegeli, Akshay Javalgikar, Vinod Matole, Lagmanna koli, Avinash Birajdar, Saurabh Nangare, Sagar Adlinge, Swaminath Ramanshetti, Akhil Patil, Yash Kothari, Pandurang Choure, Aaqueeb Mangalgiri, Sneha Ubale, Vaishnavi Dulange, Bhavana habib, Jyoti Mittha

Email(s): suyashingle18@gmail.com

DOI: 10.5958/0975-4377.2021.00013.6   

Address: Suyash Ingle*, Varsha Tegeli, Akshay Javalgikar, Vinod Matole, Lagmanna koli, Avinash Birajdar, Saurabh Nangare, Sagar Adlinge, Swaminath Ramanshetti, Akhil Patil, Yash Kothari, Pandurang Choure, Aaqueeb Mangalgiri, Sneha Ubale, Vaishnavi Dulange, Bhavana habib, Jyoti Mittha
Department of Pharmaceutical Quality Assurance, D.S.T.S. Mandal’s College of Pharmacy, Solapur-413004
*Corresponding Author

Published In:   Volume - 13,      Issue - 1,     Year - 2021


ABSTRACT:
The Purpose of writing this review on Intra-uterine drug delivery systems was to compile the recent literature with special focus on various Intra-uterine approaches that have recently become leading methodologies in the field of site specific orally administered controlled release drug delivery. The drug releases in uterine to terminate the pregranacy. Advantages and Disadvantages of IUDDS covered in details. In intrauterine drug delivery system IUD (Intauterine Devices) are used and which are of various types and which are effective for three to ten years depending on type. The IUD is a long-acting reversible method of contraception. An intra-uterine device is a special device that fits inside of the uterus. Intrauterine Device (IUD) is a small object that is inserted through the cervix and placed in the uterus to prevent pregnancy. A small string hangs down from the IUD into the upper part of the vagina. The IUD is not noticeable during intercourse. IUDs can last 1-10 years. They affect the movements of eggs and sperm to prevent fertilization. They also change the lining of the uterus and prevent implantation. IUDs are 99.2-99.9% effective as birth control. They do not protect against sexually transmitted infections, including HIV/AIDS. Insertion of an IUD takes only about 5 to 10 minutes. A clinician must insert an IUD. It is usually done when you are on your period. The clinician will perform a pelvic exam and check to see where your uterus is positioned. They will then insert a speculum into your vagina to see your cervix and then wash your cervix with an antiseptic solution. An IUD prevents pregnancy by stopping sperm from reaching an egg that your ovaries have released. It does this by not letting sperm go into the egg. The IUD will be inserted up through the opening of your cervix into your uterus. It is put inside using a special applicator that keeps the IUD flat and closed until it is at the top of your uterus.


Cite this article:
Suyash Ingle, Varsha Tegeli, Akshay Javalgikar, Vinod Matole, Lagmanna koli, Avinash Birajdar, Saurabh Nangare, Sagar Adlinge, Swaminath Ramanshetti, Akhil Patil, Yash Kothari, Pandurang Choure, Aaqueeb Mangalgiri, Sneha Ubale, Vaishnavi Dulange, Bhavana habib, Jyoti Mittha. A Brief Review on Intra-Uterine Drug Delivery Systems. Res. J. Pharma. Dosage Forms and Tech.2021;13(1):72-75. doi: 10.5958/0975-4377.2021.00013.6

Cite(Electronic):
Suyash Ingle, Varsha Tegeli, Akshay Javalgikar, Vinod Matole, Lagmanna koli, Avinash Birajdar, Saurabh Nangare, Sagar Adlinge, Swaminath Ramanshetti, Akhil Patil, Yash Kothari, Pandurang Choure, Aaqueeb Mangalgiri, Sneha Ubale, Vaishnavi Dulange, Bhavana habib, Jyoti Mittha. A Brief Review on Intra-Uterine Drug Delivery Systems. Res. J. Pharma. Dosage Forms and Tech.2021;13(1):72-75. doi: 10.5958/0975-4377.2021.00013.6   Available on: https://rjpdft.com/AbstractView.aspx?PID=2021-13-1-13


REFERENCES:
1.    Winner, B; Peipert, JF; Zhao, Q; Buckel, C; Madden, T; Allsworth, JE; Secura, GM. "Effectiveness of Long-Acting Reversible Contraception". New England Journal of Medicine, 1998-2007; (21)366.
2.    Feminist Women’s Health Center at www.FWHC.organd www.Birth-ControlComparison.info
3.    Margret chandira*, Debjit Bhowmik, chiranjib, B.jayakar Vinayaka mission University-Intra-uterine Review.
4.    Petta C, Ferriani R, Abrao M, et.al "Randomized clinical trial of a levonorgestrel-releasing intrauterine system and a depot GnRH analogue for the treatment of chronic pelvic pain in women with endometriosis.". Hum Reprod, 1993-2015; (7) 20.
5.    https://en.wikipedia.org/wiki/Intrauterine_device.
6.    Faundes A, Alvarez F, Brache V, Tejada A, "The role of the levonorgestrel intrauterine device in the prevention and treatment of iron deficiency anemia during fertility regulation.". Int J Gynaecol Obstet, 1988; 26 (3): 429-33.
7.    https://farmavita.net/farmavitanet-journal/life-science-files/53-life-science-article/1126-intra-uterine-drug-delivery-system
8.    Stanford J, Mikolajczyk R. "Mechanisms of action of intrauterine devices: update and estimation of postfertilization effects". Am J Obstet Gynecol, 2002; 187(6): 1699-708.
9.    Steenland, MW; Tepper, NK; Curtis, KM; Kapp, N. "Intrauterine contraceptive insertion postabortion: a systematic review". Contraception, Nov.2011; 84 (5): 447-64.
10.    "Mirena: Levonorgestrel-releasing intrauterine system.
11.    By Rose S, Chaudhari A, Peterson. Mirena (Levonorgestrel intrauterine system): a successful novel drug delivery option in contraception. CM. Adv Drug Deliv Rev, Aug.2009; 61(10):808-12.

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