Author(s):
Neha Thakur, Nandani Kewat, Anish Chandy
Email(s):
anishpharma@gmail.com
DOI:
10.52711/0975-4377.2026.00005 
Address:
Neha Thakur1, Nandani Kewat1, Anish Chandy2*
1Students, Pharmaceutics Department, Chouksey School of Pharmacy, CEC, Bilaspur, CG.
2Associate Professor, Pharmaceutics Department, Chouksey School of Pharmacy, CEC, Bilaspur, CG.
*Corresponding Author
Published In:
Volume - 18,
Issue - 1,
Year - 2026
ABSTRACT:
This study set out to create and assess a topical SLN-based ketoprofen nano gel. A drug's topical nano formulation gel was created, and its characterisation factors were calculated. Encapsulated ketoprofen Stearic acid and aqueous poloxomer 188 solutions were used in the solvent diffusion approach with several modifications to create nanostructured lipid carriers and solid lipid nanoparticles. Size distribution, drug entrapment effectiveness, zeta potential measurement, and scanning electron microscopy (SEM) of SLN were assessed. The optimized batch of SLN gel-encapsulated Ketoprofen was assessed for drug release kinetics. The SLN formulations were created in several size ranges, ranging from 344.3±9.567nm to 684±2.746nm. The prepared SLN was shown to have an entrapment efficacy of 53.78±1.20 to 92.13±1.23% and a zeta potential of -19.0±0.781 to -23.6±0.536mV, respectively. A kinetic analysis in the epidermis revealed a drug release percentage of 17.679±0.214 in 24hours for SLN-based nano gel and 9.773±0.158% for conventional gel, indicating greater penetration of ketoprofen from nano lipid-based gel because of the occlusive effect. Therefore, the preparation is appropriate for providing Ketoprofen SLN gel's long-lasting anti-inflammatory activity in rheumatoid arthritis.
Cite this article:
Neha Thakur, Nandani Kewat, Anish Chandy. Devlopment and Characterization of NSAIDs Loaded Lipid-Based Nanoparticle Incorporated in Gel for the Treatment of Rheumatoid Arthritis. Research Journal of Pharmaceutical Dosage Forms and Technology.2026; 18(1):28-4. doi: 10.52711/0975-4377.2026.00005
Cite(Electronic):
Neha Thakur, Nandani Kewat, Anish Chandy. Devlopment and Characterization of NSAIDs Loaded Lipid-Based Nanoparticle Incorporated in Gel for the Treatment of Rheumatoid Arthritis. Research Journal of Pharmaceutical Dosage Forms and Technology.2026; 18(1):28-4. doi: 10.52711/0975-4377.2026.00005 Available on: https://rjpdft.com/AbstractView.aspx?PID=2026-18-1-5
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