Author(s): Ashwini Gunjote, Heramb Shahane, Rani Ghosalkar, Kedar Bavaskar, Ashish Jain

Email(s): heramb.shahane19@gmail.com

DOI: 10.52711/0975-4377.2023.00025   

Address: Ashwini Gunjote*, Heramb Shahane, Rani Ghosalkar, Kedar Bavaskar, Ashish Jain
Department of Pharmaceutics, Shri D.D Vispute College of Pharmacy and Research Center, Panvel.
*Corresponding Author

Published In:   Volume - 15,      Issue - 3,     Year - 2023


ABSTRACT:
Solid lipid nanoparticles (SLNs) are introduced as an efficient carrier method for correcting dynamic medicine and water-soluble medication. Fexofenadine HCl is a long-acting selective histamine (H1) receptor antagonist with anti-inflammatory properties of the second generation. Allergic rhinitis, angioedema, and chronic urticaria are treated with fexofenadine HCl. Solid lipid nanoparticles were prepared by hot homogenization method using a solid lipid of and different polymers. A solid lipid nanoparticle created by drug and polymer poloxamer 188 in ratio showed highest entrapment efficiency as well as drug release of the medication from the solid lipid nanoparticle formulation. The prepared nanoparticles were used to formulate the nanogel using Carbopol 934. The nano-drug delivery system developed by the hot homogenization method has demonstrated their suitability for a topical route for the treatment of skin allergy. Thus, the studies revealed that the developed system has a great appeal for the convenient treatment of dermatological allergy that may overcome in improving the limitations of the existing drug delivery system. Fexofenadine HCl is a white colored powder. It is practically insoluble in water and soluble in methanol. The melting point was found to be 194.1-195.2. The FTIR spectra of Fexofenadine HCl and the mixture of drug and excipients used in the formulation of nanoparticles reveal that there was no significant interaction between the drug and polymer and other excipients used in the formulation. The optimized batches (F2) showed highest entrapment efficiency. It was observed that as there is increase in concentration of surfactant increases the entrapment efficiency. The optimized solid lipid nanoparticle formulation showed maximum drug release within 6 hr. This showed that the increase in the concentration of surfactant there was increase in drug release from the SLN.


Cite this article:
Ashwini Gunjote, Heramb Shahane, Rani Ghosalkar, Kedar Bavaskar, Ashish Jain. Preparation and Optimization of Fexofenadine HCl Solid lipid Nanoparticles. Research Journal of Pharmaceutical Dosage Forms and Technology. .2023; 15(3):151-6. doi: 10.52711/0975-4377.2023.00025

Cite(Electronic):
Ashwini Gunjote, Heramb Shahane, Rani Ghosalkar, Kedar Bavaskar, Ashish Jain. Preparation and Optimization of Fexofenadine HCl Solid lipid Nanoparticles. Research Journal of Pharmaceutical Dosage Forms and Technology. .2023; 15(3):151-6. doi: 10.52711/0975-4377.2023.00025   Available on: https://rjpdft.com/AbstractView.aspx?PID=2023-15-3-1


REFERENCES:
1.    Amol S. Deshmukh. Solid Lipid Nanoparticles. Research Journal of Pharmaceutical Dosage Forms and Technology. 2014,6(4), 282-285.
2.    Bansal K.K, Mishra V, Verma A, Yadav N, Solid Lipid Nanoparticles: Emerging Colloidal Nano Drug Delivery Systems. Pharmaceutics, 2018, 10, pg. no-191.
3.    Akshat Sharma, Amit Dubey, Reenu Yadav Solid Lipid Nanoparticles: A Promising Nanotechnology. Research Journal of Pharmaceutical Dosage Forms and Technology.2011, 3(5), 167-175.
4.    Wake P.S., Kshirsagar M.D. Design and Characterization of Solid Lipid Nanoparticle Based Transdermal Drug Delivery System. Asian Journal of Research in Pharmaceutical Science. 2017, 7 (2), 87.
5.    More S., Lokhande S., Raje V. Review on Solid Lipid Nanoparticles for Ophthalmic Delivery. Research Journal of Pharmaceutical Dosage Forms and Technology.  2019, 11 (1), 19.
6.    Swamy S K., Alli R. Preparation, Characterization and Optimization of Irbesartan Loaded Solid Lipid Nanoparticles for Oral Delivery. Asian Journal of Pharmacy and Technology. 2021, 97–104.
7.    Qushawy M, Ali N. Solid Lipid Nanoparticles (SLNs) As Nano Drug Delivery Carriers: Preparation, Characterization and Application.Int J App Pharm. 2020; 12(1), 1-9.
8.    Patel N. N., Roop Chandani V. K., Gupta A. Proniosomes for Improved Transdermal Drug Delivery. The Pharma res J Pharm Res.2013, 8(2), 62-82.
9.    Maghraby EI, Williams GM, Barry BW. Skin Delivery of Oestradiol from Lipid Vesicles: Importance of Liposome Structure. Int J Pharma. 2000, 204(1-2), 159-69
10.    Vakhariya R.R., Talokar S.S. , Salunkhe V.R., Magdum C.S. Formulation Development and Optimization of Simvastatin Loaded Solid Lipid Nanoparticles. Asian Journal of Research in Pharmaceutical Science. 2017, 7 (1), 49.
11.    Sujan M.N., Patil A.B., Gowda D.V. A Review on Methods of Preparation and Characterization of the Solid Lipid Nanoparticles. Research Journal of Pharmacy and Technology. 2020, 13 (7), 3433.
12.    P. Ekambaram, A. H. Sathali. Formulation and Evaluation of Solid Lipid Nanoparticles of Ramipril. J Young. Pharm. 2018, 3.
13.    M.G. Shah, M. Tajmal, R. Karki. Formulation and evaluation of fexofenadine hydrochloride loaded chitosan nanoparticles. Int. J. Pharm. Sci. Res.2020, 11(6): 2969-2975.
14.    Verma S, Makkar D. Solid Lipid Nanoparticles: A Comprehensive Review. J. Chem. Pharm. Res.2016, 8(8), 102-114.
15.    G. Abdelbary and R. H. Fahmy, Diazepam loaded solid lipid nanoparticles: Design and characterization, AAPS. Pharma. Sci. Tech, 2009, 10 (1).
16.    Dhiman, S., Thakur, G. S., Anand, S., and Yadav, P. Formulation and Evaluation of Solid Lipid Nanoparticles for controlled delivery of Zidovudine. Research Journal of Pharmacy and Technology. 2021, 2548–2556.
17.    P. Ekambaram, A. Abdul Hasan Sathali, K. Priyanka. Solid Lipid Nanoparticles: A Review. Sci. Revs. Chem. Commun. 2012, 2(1), 80-102.
18.    Ellen K. G. Mhango, Preparation and Optimization of Meropenem-Loaded Solid Lipid Nanoparticles: In Vitro Evaluation and Molecular Modeling.AAPS. Pharm. Sci. Tech.2016, DOI: 10.1208/s12249-016-0675.
19.    Nachammai K, Keerthi G S Nair, Ramaiyan Velmurugan, Sathesh Kumar S, Pavithra K.Sustained – Release study on Mefenamic acid and Mosapride loaded solid lipid Nanoparticles: In vitro Characterization.Research Journal of Pharmacy and Technology. 2020, 13(11), 5391-5395.
20.    Ashok P., Meyyanathan S. N., Vadivelan R., Jawahar N. Nanosuspensions by Solid Lipid Nanoparticles Method for the Formulation and in Vitro/in Vivo, Characterization of Nifedipine. Asian Journal of Research in Pharmaceutical Science. 2021, 11(1), 1–6.
21.    Basha, B. N.; Prakasam, K.; Goli, D..Formulation and Evaluation of Gel containing Fluconazole Antifungal Agent. Int. J. Drug Dev. Res. 2011, 3(4), 109-128.
22.    Thakur N, Jain P, Jain V. Formulation Development and Evaluation of Transfersomal Gel. J. Drug. Deliv. Ther. 2018, 8(5), 168-177.
23.    Goyal, S., Sharma P., Ramchandani U., Shrivastava S. K., Dubey P.K. Novel Anti- inflammatory topical Herbal Gels Containing Withania somnifera and Boswellia serrata. Int.  J. Pharm. Biol. Archives. 2011; 2(4), 1087-1094.
24.    S. Singh, A.K. Dobhal, Formulation and Evaluation of Solid Lipid Nanoparticles of a Water-Soluble Drug: Zidovudine, Chem. Pharm. Bull. 2010, 58(5) 650—655. Ind J Pharma Sci.2004; 66. Pg. no-121-123.
25.    Kumar L., Verma R. In vitro Evaluation of Topical Gel Prepared using Natural Polymer. Int. J. Drug Delivery. 2010; 2, 58-63.
26.    Patel J., Patel B., Banwait H., Parmar K., Patel M. Formulation and Evaluation of Topical Aceclofenac Gel Using Different Gelling Agent. Int. J. Drug Dev. Res. 2011; 3(1), 156-164.
27.    Gupta, A., Mishra A.K., Singh A. K., Gupta V., Bansal P. Formulation and Evaluation of Topical Gel of Diclofenac sodium using Different Polymers. Drug Invention Today. 2010; 2(5), 250-253.
28.    Takahashi Y. I, Ishihara C, Onishi H. Formulation and Evaluation of Morin-Loaded Solid Lipid Nanoparticles. Biol. Pharm. Bull. 2016; 39, 1514–1522.
29.    Mutimer M. N., Rifkin C., Hill J. A., Glickman M.N., Cyr G.N. Modern Ointment Bases Technology – II – Comparative Evaluation of Bases. J. Am. Pharm. Assoc. 1956; 45, 212-218.
30.    Kesharwani R, Sachan A, Singh S, Patel D. Formulation and Evaluation of Solid Lipid Nanoparticle (SLN) Based Topical Gel of Etoricoxib. J. App. Pharm. Sci. 2016; 6(10), 124-131.
31.    Rathod H.J and Mehta D.P. A Review on Pharmaceutical Gel. Int J Pharm Sci.2015, 1, 33-47.

Recomonded Articles:

Author(s): Gopal Rao M., M. A. Amutha Gnana Arasi, S. Jayaprakash, M. Arun Kumar, P. Kavitha

DOI:         Access: Open Access Read More

Author(s): Yamunappa, Ravi Kumar, Pooja Shetty, Prathibha Suvarna, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00012.4         Access: Open Access Read More

Author(s): Vidya N. Dange, Shubhangi J. Shid, Sagar B. Patil, Ganesh B. Vambhurkar, Mangesh A. Bhutkar

DOI: 10.5958/0975-4377.2019.00010.7         Access: Open Access Read More

Author(s): Varsha R. Sandhan, S.B. Gondkar, R. B. Saudagar

DOI:         Access: Open Access Read More

Author(s): Dilip M. Kumbhar, Kailas K. Mali, Remeth J. Dias, Vijay D. Havaldar, Vishwajeet S. Ghorpade, Nitin H. Salunkhe.

DOI: 10.5958/0975-4377.2016.00036.7         Access: Open Access Read More

Author(s): Akelesh T., R. Ramya, Venkatesh. P., Divya Jacob , R. Venkatnarayanan

DOI:         Access: Open Access Read More

Author(s): Swati S Talokar, Rohan R Vakhariya

DOI: 10.5958/0975-4377.2017.00001.5         Access: Open Access Read More

Author(s): Patil Amol M, Todkar Rohit R, Gumte Dipak S, S.K. Mohite, C.S. Magdum

DOI: 10.5958/0975-4377.2016.00030.6         Access: Open Access Read More

Author(s): Shoaib Ahmad

DOI: 10.5958/0975-4377.2016.00041.0         Access: Open Access Read More

Author(s): Sandeep Gupta, Dheeraj Ahirwar, Neeraj K Sharma, Deenanath Jhade

DOI:         Access: Open Access Read More

Author(s): V. Kalyani, K. Basanthi , T.E.G.K. Murthy

DOI:         Access: Open Access Read More

Author(s): Ashok A Hajare, Mahesh N Mali, Arun S Dange, Sushil M Sarvagod, Shweta V Patwardhan ,Sachin T Kurane

DOI:         Access: Open Access Read More

Author(s): Suraj R. Wasankar, Kshitij V. Makeshwar, Abhishek D. Deshmukh, Rahul M. Burghate

DOI:         Access: Open Access Read More

Author(s): Swapnali A. Mohite, R. R. Vakhariya, S. K. Mohite, C. S. Magdum

DOI: 10.5958/0975-4377.2019.00017.X         Access: Open Access Read More

Author(s): M.S. Gambhire, S. Lilke , V.M. Gambhire

DOI:         Access: Open Access Read More

Author(s): Shivi Sondhi, Navdeep Singh, Kamya Goyal, Shammy Jindal

DOI: 10.5958/0975-4377.2021.00003.3         Access: Open Access Read More

Author(s): Shubham Tripathi, Somnath Patel, Ritesh Patel, Shraddha,Pushpendra, Sachin,Neetish, Mahendra, Kuldeep, Prashant, Rajesh Patel, Girish, Nitin, Tomanlal, Amrita Thakur, Mukta Agrawal, Ajazuddin, D. K. Tripathi, Amit Alexander

DOI: 10.5958/0975-4377.2018.00019.8         Access: Open Access Read More

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0975-4377 


Recent Articles




Tags