Research Journal of Pharmaceutical Dosage Forms and Technology

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0975-4377 (Online)
0975-234X (Print)


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Cleaning Validation of Paracetamol Tablets as a Dosage Formulation

Author(s): Hapse S.A., Bhagat B.V., Wagh V.S., Kadaskar P.T.

Email(s): sandiphapse@gmail.com

DOI: Not Available

Address: Hapse S.A.*, Bhagat B.V., Wagh V.S. and Kadaskar P.T.
Department of Quality Assurance Technique, Padmashree Dr. Vithalrao Vikhe Patil College of Pharmacy, Ahmednagar. Maharashtra. 414111.
*Corresponding Author:

Published In:   Volume - 3,      Issue - 5,     Year - 2011

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ABSTRACT:
Cross1 contamination is one of the major problems focused in manufacturing of drugs utilizing common facility which leads to inferior quality of final product and cause considerable loss to the company. Contamination of one batch product with significant levels of residual active ingredients from a previous batch and contamination by microorganisms are the real concern. Cleaning and decontamination is one of the major and critical activity in pharmaceutical operations. The concept of purity and safety are directly related to the cleaning operations. Cleaning programmers are necessary simply to prevent our manufactured products from being contaminated. These are cross-contamination of one product into another , product contamination by a foreign material and microbial contamination The cleaning validation is a documented process that proves the effectiveness and consistency cleaning of pharmaceutical equipments to meet the regulatory requirements. Manufacturing of paracetamol and other tablets utilizing common facility, where paracetamol could be a possible cross contaminant. Hence the present study was carried out to validate the cleaning activity from both regulatory and quality prospective. Visual inspection, Swab sampling for chemical residue and for microbiological analysis were carried out to validate cleaning activity and results from all methods were complying with acceptance criteria.


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Cite this article:
Hapse S.A., Bhagat B.V., Wagh V.S. , Kadaskar P.T.. Cleaning Validation of Paracetamol Tablets as a Dosage Formulation. Research J. Pharma. Dosage Forms and Tech. 2011; 3(5): 215-219 .

Cite(Electronic):
Hapse S.A., Bhagat B.V., Wagh V.S. , Kadaskar P.T.. Cleaning Validation of Paracetamol Tablets as a Dosage Formulation. Research J. Pharma. Dosage Forms and Tech. 2011; 3(5): 215-219 .   Available on: https://rjpdft.com/AbstractView.aspx?PID=2011-3-5-9


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Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

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DOI: 10.5958/0975-4377 

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Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. The aim of RJPDFT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPDFT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical Chemistry, Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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