Author(s): Shaikh Samir K., Shashikant D. Barhate

Email(s): shaikhsamir07690769@gmail.com

DOI: 10.52711/0975-4377.2025.00014   

Address: Shaikh Samir K., Shashikant D. Barhate
Shri Sureshdada Jain Institute of Pharmaceutical Education and Research, Jamner, 424206.
*Corresponding Author

Published In:   Volume - 17,      Issue - 2,     Year - 2025


ABSTRACT:
The objective of this present investigation was to formulate, develop and evaluate gastro-retentive floating sustained release alginate beads of Aspirin it was prepared by the simple ionotropic gelation method and it provides better product and result. The floating beads were prepared by dispersing Aspirin together with aluminum dichloride (2 % w/v) (as gas forming agent) into a solution of sodium alginate and HPMC K4M, HPMC K15M, HPMC K100M. The resulting solution was then extruded through a 22-gauge syringe needle into 100 ml cross-linking solution containing calcium chloride (2 % w/v) plus acetic acid (10% v/v). Prepared beads were evaluated for their micromeritic characteristics, particle size, encapsulation efficiency, buoyancy test. The drug entrapment efficiency was increased with the increment of polymer ratio. All of the formulations (ASP1 to ASP5) floated immediately or with a very short lag time and remained floating up to 11 hours. Gastroprotective multiarticulate drug delivery system of drugs like aspirin for the effective management of muscles aches, inflammation and headaches. Rough and porous surface was observed in microscopic. The beads demonstrated favorable in-vitro floating ability. Prepared formulations showed better sustained release behavior. It was concluded that beads of Alginate could be serve as an effective carrier for drugs like aspirin for the sustained release drug delivery.


Cite this article:
Shaikh Samir K., Shashikant D. Barhate. Formulation Development and Evaluation of Sustained Release Floating Beads of Aspirin. Research Journal of Pharmaceutical Dosage Forms and Technology. 2025; 17(2):97-1. doi: 10.52711/0975-4377.2025.00014

Cite(Electronic):
Shaikh Samir K., Shashikant D. Barhate. Formulation Development and Evaluation of Sustained Release Floating Beads of Aspirin. Research Journal of Pharmaceutical Dosage Forms and Technology. 2025; 17(2):97-1. doi: 10.52711/0975-4377.2025.00014   Available on: https://rjpdft.com/AbstractView.aspx?PID=2025-17-2-2


REFERENCES:
1.    Harshita Vijay et al. Formulation and Evaluation of Floating Beads of Aceclofenac Sodium for GRDDS. International Journal of Creative Research Thoughts. 2024; 12(6): 274-281.
2.    Soumen Dey et al. Design and Characterization of Controlled Release Hydrophilic Polymers Based Floating Beads of Cefixime. JKEPES. 2023; 21(4): 136-143.
3.    D. Supriya et al. Review on Floating Beads. International Journal of Research and Analytical Reviews. 2023; 10(2): 452-459.
4.    Vidya Sabale et al. Development and statistical optimization of carvedilol floating beads for chronotherapeutic drug delivery. Istanbul Journal of Pharm. 2023; 53(2): 140-149.
5.    Manisha U Mishra et al. Preparation and Evaluation of Floating Beads of Analgesic Drug. International Journal of All Research Education and Scientific Methods.  2023; 11(7): 1016-1024.
6.    Roshan Kumar Dubay et al. Development and Characterization of Floating Beads Containing the BCS Class II Drug Lumefantrine Ternary Complex. Inventi Rapid: Pharmaceutical Process Development. 2023; 1: 1-5.  
7.    G. Balaji Kalpana et al. Formulation Optimization and Evaluation of Gastroretentive Alginate Beads of Ivacaftor by Using Factorial Design. Journal of Clinical and Pharmaceutical Research. 2022; 1(2): 16-25.
8.    Pratibha Gupta et al. Formulation and Characterization of Floating Beads to Deliver Aspirin. ASIO Journal of Pharmaceutical & Herbal Medicines Research (ASIO-JPHMR). 2022; 8(1): 15-19.
9.    Likitha B. etal, Formulation and Evaluation of Floating Beads of Nizatidine. International Journal of Pharmaceutical Research and Applications. 2022; 7(3); 449-457.
10.    Meenakshi Bharkatiya et al. Preparation and Evaluation of Floating Micro Beads for Gastro Retentive Drug Delivery System of Antiulcer Drug. International Journal of Pharmaceutical Sciences and Research. 2022; 13(9): 3792-3806.
11.    Dr. Chen Lei et al. Evaluation Parameters and In-Vitro Studies of Floating Beads of Analgesic Drug. International Journal of Multidisciplinary Innovation and Research Methodology. 2022; 1(1): 28-33.
12.    Achal Anand et al. Development and in-vitro evaluation of poloxamer alginate floating bead containing glimepiride using foam technology. International Journal of Health Sciences. 2022; 6(S5): 10827–10839.
13.    Mageshwari Kanniyappan et al. Formulation and Evaluation of Floating Alginate Microbeads of Hydralazine Hydrochloride. International Journal of Pharmaceutical Sciences Review and Research. 2021; 67(2): 87-93.
14.    Daisy P.A et al. Formulation and evaluation of floating beads of esomeprazole magnesium USP, International Journal of Pharmaceutical Chemistry and Analysis.  2019;  6(2): 40-43.
15.    Khalifa My et al. Formulation and Characterization of Floating Beads of Antibiotic by Emulsion Gelation Technique. Asian Journal of Pharmaceutical and Clinical Research. 2019; 12(5): 57-62.
16.    Rajesh Kumar Sharma et al. Development, Characterization and bioavailability enhancement of oral floating sustained release beads containing Indomethacin. Indian Journal of Pharmaceutical and Biological Research. 2018; 6(4): 48-54.
17.    S. M. Deepak Vallamsetti et al. Formulation and Evaluation of Floating Beads of Famotidine. International Journal of Pharmaceutical Sciences Review and Research. 2014; 24(1): 192-198.
18.    Anup Singh et al. Formulation Evaluation of Sustained Release Floating Beads of Metformin Hydrochloride Using Sodium Alginate. International Journal of Pharma Professional Research. 2014; 5(1); 953-957.
19.    Ramadevi Bhimavarapu et al. Design, development and in vitro evaluation of gastro retentive alginate floating beads for ranitidine hydrochloride. Journal of Chemical and Pharmaceutical Research. 2013; 5(4): 377-381.
20.    Basappa Veerbhadraiah Basavaraj et al. Formulation and Evaluation of Floating Alginate Beads of an Anti-Ulcer Drug. International Journal of Pharmaceutical Sciences Review and Research. 2013; 21(2): 120-124.

Recomonded Articles:

Author(s): Yamunappa, Ravi Kumar, Pooja Shetty, Prathibha Suvarna, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00012.4         Access: Open Access Read More

Author(s): Isha Shah, Nensi Raytthatha, Jigar Vyas, Umesh Upadhyay

DOI: 10.52711/0975-4377.2021.00039         Access: Open Access Read More

Author(s): Sayad Basha.K, Sheema Nafees. S, Nethravani. G, Thirumalesh Naik S.B

DOI: 10.5958/0975-4377.2016.00015.X         Access: Open Access Read More

Author(s): Swapnali A. Mohite, R. R. Vakhariya, S. K. Mohite, C. S. Magdum

DOI: 10.5958/0975-4377.2019.00017.X         Access: Open Access Read More

Author(s): Swati Talokar, Rohan R Vakhariya, A.R Dhole

DOI: 10.5958/0975-4377.2017.00005.2         Access: Open Access Read More

Author(s): Debjit Bhowmik, Rishab Bhanot, K.P. Sampath Kumar

DOI: 10.5958/0975-4377.2018.00035.6         Access: Open Access Read More

Author(s): Rajkumar Prasad Yadav, F. R. Sheeba

DOI: 10.52711/0975-4377.2021.00023         Access: Open Access Read More

Author(s): Doppalapudi Sandeep, A. P. Pratyusha, G. Sudheshna, K. Lakshmi prasanna, P. Sreekanth

DOI:         Access: Open Access Read More

Author(s): Sushant R. Jagtap, D.G Phadtare, R.B. Saudagar

DOI: 10.5958/0975-4377.2016.00021.5         Access: Open Access Read More

Author(s): Priti B. Savant, Shrikrushna A. Shinde, Jayamala S. Barge

DOI: 10.52711/0975-4377.2022.00042         Access: Open Access Read More

Author(s): Jigar Vyas, Jai Mehta, Neha Pal, Kapil Daxini

DOI: 10.5958/0975-4377.2020.00002.6         Access: Open Access Read More

Author(s): Sawant VA, Jayprabha P, Shende VS, Borkar SN, Wakale VS, Deore SR, Dame GY, Barve AO, Chatap VK

DOI:         Access: Open Access Read More

Author(s): P. Lekshmi, K. Pramod, K.C. Ajithkumar

DOI: 10.5958/0975-4377.2016.00007.0         Access: Open Access Read More

Author(s): V. Kalyani, K. Basanthi , T.E.G.K. Murthy

DOI:         Access: Open Access Read More

Author(s): Swati Rawat, Shradha Sangali, Akhilesh Gupta

DOI: 10.5958/0975-4377.2018.00001.0         Access: Open Access Read More

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0975-4377 


Recent Articles




Tags