Author(s):
Gayathri M K, Pavithra K, Vishnu T, Ragavendhiran M, S Meena
Email(s):
meenus1493@gmail.com
DOI:
10.52711/0975-4377.2026.00049 
Address:
Gayathri M K1, Pavithra K2, Vishnu T3, Ragavendhiran M4, S Meena5*
1Department of Pharmaceutics, JKKN College of Pharmacy, Komarapalayam, 638183, Tamil Nadu, India. ORCID ID: 0009-0009-3253-1547.
2Department of Pharmaceutics, JKKN College of Pharmacy, Komarapalayam, 638183, Tamil Nadu, India. ORCID ID: 0009-0005-5891-1936.
3Department of Pharmaceutics, JKKN College of Pharmacy, Komarapalayam, 638183, Tamil Nadu, India. ORCID ID: 0009-0006-8388-4690.
4Department of Pharmaceutics, JKKN College of Pharmacy, Komarapalayam, 638183, Tamil Nadu, India. ORCID ID: 0009-0005-4079-1681.
5*Assistant Professor, Department of Pharmaceutics, JKKN College of Pharmacy, Komarapalayam, 638183, Tamil Nadu, India. ORCID ID: 0009-0008-1078-8707.
*Corresponding Author
Published In:
Volume - 18,
Issue - 4,
Year - 2026
ABSTRACT:
Background: Aspirin has a short biological half-life and may cause gastrointestinal irritation, creating a rationale for sustained-release delivery. This study evaluated crude Musa sp. banana peel powder (BPP), an abundant polysaccharide-rich agricultural by-product, as a natural matrix former and compared its performance with hydroxypropyl methylcellulose (HPMC). Methods: Aspirin matrix tablets were prepared by dry granulation using 60 mg BPP (F1), 90 mg BPP (F2), or HPMC as the reference polymer. BPP swelling, powder flow, tablet weight variation, friability, hardness, thickness, 12-hour in-vitro drug release, and release kinetics were evaluated. Results: BPP exhibited a swelling index of 156.91%, confirming appreciable hydration capacity. All batches showed workable flow and acceptable physical characteristics, although HPMC produced the strongest tablets and lowest friability. Increasing BPP from 60 to 90 mg improved hardness from 4.40 to 5.97 kg/cm² and reduced friability from 0.83% to 0.54%. F1 released 82.7% aspirin within 3 hours, demonstrating inadequate retardation. In contrast, F2 released 44.3%, 69.8%, and 97.6% at 3, 6, and 12hours, respectively, closely approaching the HPMC profile of 42.8%, 67.7%, and 98.4%. Mean dissolution times were 2.28, 5.40, and 5.76 hours for F1, F2, and HPMC, respectively. F2 and HPMC fitted the Korsmeyer–Peppas model (R²=0.9962 and 0.9984) and showed anomalous non-Fickian transport. Conclusion: At 90 mg, crude BPP formed a functional hydrophilic matrix capable of sustaining aspirin release for 12 hours, with performance approaching HPMC. Its pharmaceutical use requires excipient standardization, compatibility, stability, salicylic-acid, content-uniformity, batch-reproducibility, and in-vivo studies before it can be considered a viable alternative.
Cite this article:
Gayathri M K, Pavithra K, Vishnu T, Ragavendhiran M, S Meena. Formulation and Evaluation of Aspirin Sustained Release Tablets: A Comparative Study of Musa sp. (Banana) Peel Powder Versus Semi-Synthetic Polymer. Research Journal of Pharmaceutical Dosage Forms and Technology. 2026; 18(4):350-8. doi: 10.52711/0975-4377.2026.00049
Cite(Electronic):
Gayathri M K, Pavithra K, Vishnu T, Ragavendhiran M, S Meena. Formulation and Evaluation of Aspirin Sustained Release Tablets: A Comparative Study of Musa sp. (Banana) Peel Powder Versus Semi-Synthetic Polymer. Research Journal of Pharmaceutical Dosage Forms and Technology. 2026; 18(4):350-8. doi: 10.52711/0975-4377.2026.00049 Available on: https://rjpdft.com/AbstractView.aspx?PID=2026-18-4-11
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