Author(s):
Gauri Dewangan, Pratikshya Panda, Anju Mishra, Digeshwari Patel, Anish Chandy
Email(s):
anishc@cecbilaspur.ac.in
DOI:
10.52711/0975-4377.2026.00048 
Address:
Gauri Dewangan1, Pratikshya Panda1, Anju Mishra2, Digeshwari Patel2, Anish Chandy3
1Students, School of Pharmacy, Chouksey Engineering College, Bilaspur, Chhattisgarh, India.
2Assistant Professor, School of Pharmacy, Chouksey Engineering College, Bilaspur, Chhattisgarh, India.
3Associate Professor, School of Pharmacy, Chouksey Engineering College, Bilaspur, Chhattisgarh, India.
*Corresponding Author
Published In:
Volume - 18,
Issue - 4,
Year - 2026
ABSTRACT:
Levocetirizine dihydrochloride is a potent oral third-generation antihistamine that is not sedative in nature and is prescribed for the treatment of allergic rhinitis, both seasonal and perennial. The objective of the current study was to create immediate-release films of levocetirizine that could produce instant therapeutic effects that are helpful in managing serious allergy attacks, enhancing bioavailability of the drug, and increasing convenience of administration. Films of levocetirizine dihydrochloride were prepared using either single polymer or combination of two polymers that include hydroxypropyl methylcellulose (HPMC) and polyvinyl alcohol (PVA) by means of the solvent casting method, and underwent evaluation of the physical properties that included weight uniformity, thickness, tensile strength, elongation, surface pH, folding endurance, and drug content uniformity, yielding satisfactory results. The formulations underwent tests of disintegration and in vitro drug release and were subjected to in vivo studies on rats. Fast dissolving films of levocetirizine dihydrochloride with HPMC were found to demonstrate a greater rate of dissolution than normal tablets. Levocetirizine dihydrochloride fast dissolving films may be clinically applied in the treatment of allergic rhinitis and other allergic diseases when prompt onset of action of the dosage form is needed and the user-friendliness of the application is wanted.
Cite this article:
Gauri Dewangan, Pratikshya Panda, Anju Mishra, Digeshwari Patel, Anish Chandy. Development and Optimization of Oral Films of Levocetrizine using Natural Polymer. Research Journal of Pharmaceutical Dosage Forms and Technology. 2026; 18(4):345-9. doi: 10.52711/0975-4377.2026.00048
Cite(Electronic):
Gauri Dewangan, Pratikshya Panda, Anju Mishra, Digeshwari Patel, Anish Chandy. Development and Optimization of Oral Films of Levocetrizine using Natural Polymer. Research Journal of Pharmaceutical Dosage Forms and Technology. 2026; 18(4):345-9. doi: 10.52711/0975-4377.2026.00048 Available on: https://rjpdft.com/AbstractView.aspx?PID=2026-18-4-10
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22. Pacheco et al., 2021 — excellent scientific basis for selecting natural polymers such as pullulan, starch, alginate, pectin, gelatin and chitosan.
23. Gupta et al., 2023 — useful experimental precedent for pullulan-based films, including formulation and characterization.
24. Jadach et al., 2024 — particularly useful if you are considering sodium alginate as your primary natural film-forming polymer.
25. Helfenstein et al., 2024 — useful for pectin/starch-based oral films and natural-polymer combinations.
26. Wargantiwar and Bhattacharya, 2025 — very recent review supporting the scientific rationale for natural polymers in oral thin films.
27. Patel and Modi, 2012 and Kathpalia and Patil, 2017 — important levocetirizine-specific formulation precedents, even though they are older.