Author(s):
Lata Choudhary, Satish Sahu, Mohammad Akhtar Rasool, Arin Bhattacharya, Suman Kumar Rathore, Rishikesh
Email(s):
drsksahu11@gmail.com , sumanpharm123@gmail.com
DOI:
10.52711/0975-4377.2026.00042 
Address:
Lata Choudhary1, Satish Sahu3, Mohammad Akhtar Rasool3, Arin Bhattacharya4, Suman Kumar Rathore5*, Rishikesh6
1,2,4,5,6J.K. College of Pharmacy, Near Gatora Railway Station, Bilaspur (C.G.) India.
3Tagore Institute of Pharmacy and Research, Sakri, Bilaspur (C.G.), India.
*Corresponding Author
Published In:
Volume - 18,
Issue - 4,
Year - 2026
ABSTRACT:
Buccal bioadhesive films are increasingly investigated as patient-friendly orotransmucosal dosage forms for drugs that undergo extensive first-pass metabolism after oral administration. This paper presents a formulation-oriented research design for propranolol hydrochloride as a model first-pass metabolized drug. The objective is to develop thin, flexible and mucoadhesive films capable of sustaining drug release, prolonging residence time on the buccal mucosa and improving systemic bioavailability by avoiding portal hepatic metabolism. The proposed films are prepared by solvent casting using hydroxypropyl methylcellulose, Carbopol, polyvinyl alcohol, polyethylene glycol 400 and menthol as functional excipients. The paper discusses preformulation studies, compatibility assessment, formulation composition, film evaluation parameters, in vitro release, ex vivo permeation, mucoadhesion, stability and pharmacokinetic assessment. Expected results indicate that optimized polymer ratios can produce uniform films with acceptable surface pH, high folding endurance, controlled swelling, sustained release over eight hours and improved permeation flux. The discussion emphasizes the relationship between polymer hydration, adhesion, mechanical strength, drug diffusion and mucosal permeability. The findings support buccal bioadhesive films as a promising alternative to conventional oral dosage forms for drugs limited by hepatic first-pass metabolism, while also highlighting the need for safety, stability, palatability and clinical validation before translation.
Cite this article:
Lata Choudhary, Satish Sahu, Mohammad Akhtar Rasool, Arin Bhattacharya, Suman Kumar Rathore, Rishikesh. Design and Evaluation of Buccal Bioadhesive Films for Improved Bioavailability of a First-Pass Metabolized Drug. Research Journal of Pharmaceutical Dosage Forms and Technology. 2026; 18(4):305-0. doi: 10.52711/0975-4377.2026.00042
Cite(Electronic):
Lata Choudhary, Satish Sahu, Mohammad Akhtar Rasool, Arin Bhattacharya, Suman Kumar Rathore, Rishikesh. Design and Evaluation of Buccal Bioadhesive Films for Improved Bioavailability of a First-Pass Metabolized Drug. Research Journal of Pharmaceutical Dosage Forms and Technology. 2026; 18(4):305-0. doi: 10.52711/0975-4377.2026.00042 Available on: https://rjpdft.com/AbstractView.aspx?PID=2026-18-4-4
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