Author(s): Amallia Rachmasari, Rafidha Aisyah Kartini, Gita Alviani, Indah Solihah

Email(s): amalliarachmasari@gmail.com , rafidhaaisyah@gmail.com , gitaalviani99@gmail.com , indahsolihah@mipa.unsri.ac.id

DOI: 10.5958/0975-4377.2019.00046.6   

Address: Amallia Rachmasari, Rafidha Aisyah Kartini, Gita Alviani, Indah Solihah*
Department of Pharmacy, Sriwijaya University, Inderalaya 30662, South Sumatera, Indonesia
*Corresponding Author

Published In:   Volume - 11,      Issue - 4,     Year - 2019


ABSTRACT:
The aims of this study was to investigate the healing effect of spray gel collagen extract from Channa striata wastes bones in a deep second-degree burn model in rats. Collagen extraction was used acid soluble collagen (ASC) method. Spray gel collagen extract was used Carbopol® 940 and HPMC-60SH as gelling agent. The quality control of spray gel collagen extract was evaluated for physical appearance, adhesive strength, pH, viscosity, pump delivery, and spray pattern. The in vivo study was used 24 adults, male Wistar-albino rats, divided into 4 groups. The first was normal saline (NS) groups as negative control. The second was base spray gel (BSG) group as placebo. The third was Bioplacenton® group as positive control. And the last was spray gel collagen extract (SCE) group as treatment group. The percentage of wound contraction was observed every 2 days for 14 days, followed by observation in the period of epithelialization of the wound. Collagen extraction with ASC method has 1.927,14±4,76 ppm of total protein. The results of quality control of SCE meets all standard value for gel preparation. Furthermore, the result of in vivo study showed that SCE group has the best rate of burn wound healing among all control groups, and significantly better than NS and BSG groups. In conclusion, application of SCE is effective in healing burn-related skin wounds in the rat model as well as Bioplacenton® gel.


Cite this article:
Amallia Rachmasari, Rafidha Aisyah Kartini, Gita Alviani, Indah Solihah. Healing effect of Spray gel collagen extract from Channa striata bone on burn in rats. Res. J. Pharma. Dosage Forms and Tech.2019; 11(4):275-279. doi: 10.5958/0975-4377.2019.00046.6

Cite(Electronic):
Amallia Rachmasari, Rafidha Aisyah Kartini, Gita Alviani, Indah Solihah. Healing effect of Spray gel collagen extract from Channa striata bone on burn in rats. Res. J. Pharma. Dosage Forms and Tech.2019; 11(4):275-279. doi: 10.5958/0975-4377.2019.00046.6   Available on: https://rjpdft.com/AbstractView.aspx?PID=2019-11-4-6


Recomonded Articles:

Author(s): Gopal Rao M., M. A. Amutha Gnana Arasi, S. Jayaprakash, M. Arun Kumar, P. Kavitha

DOI:         Access: Open Access Read More

Author(s): Suyash Ingle, Varsha Tegeli, Akshay Javalgikar, Vinod Matole, Lagmanna koli, Avinash Birajdar, Saurabh Nangare, Sagar Adlinge, Swaminath Ramanshetti, Akhil Patil, Yash Kothari, Pandurang Choure, Aaqueeb Mangalgiri, Sneha Ubale, Vaishnavi Dulange, Bhavana habib, Jyoti Mittha

DOI: 10.5958/0975-4377.2021.00013.6         Access: Open Access Read More

Author(s): Hapse S.A., Bhagat B.V., Wagh V.S. , Kadaskar P.T.

DOI:         Access: Open Access Read More

Author(s): Domendra Sahu, Shekhar Verma , Ravindra D. Dubey

DOI:         Access: Open Access Read More

Author(s): Deore Nisha N., R. K. Surawase

DOI: 10.52711/0975-4377.2022.00055         Access: Open Access Read More

Author(s): A Maru, U Pattamatta , VB Patravale

DOI:         Access: Open Access Read More

Author(s): Swapnil T. Deshpande, P. S. Vishwe, Rohit D. Shah, Swati S. Korabu, Bhakti R. Chorghe, DG Baheti

DOI:         Access: Open Access Read More

Author(s): Dipti G. Phadtare, Amol R. Pawar, R.B. Saudagar, Govind K.Patil

DOI: 10.5958/0975-4377.2017.00002.7         Access: Open Access Read More

Author(s): Yamunappa, Ravi Kumar, Pooja Shetty, Prathibha Suvarna, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00012.4         Access: Open Access Read More

Author(s): Simila Madathil, RaviKumar, Anju Govind, Mercy Mathew, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00013.6         Access: Open Access Read More

Author(s): Kritika Kanoujia, Chandraprabha Dewangan, Ayushi Masih, Dipti Sinha, Divya Oraon, Manisha Jaiswal, Monika Sahu, Ranjeeta Kumari, Sapna Pradhan, Ravi Suman, Rajkishan Dewangan, Roman Banjare, Pradeep Paikra, Mukesh Rawtiya, Mukta Agrawal, Ajazuddin, D. K. Tripathi, Amit Alexander

DOI: 10.5958/0975-4377.2018.00015.0         Access: Open Access Read More

Author(s): Soham Shukla, Vikram Pandya, Praful Bhardia, Nitin Jonwal, Shashank Mishra, Deepak Bhatt, Deependra Jain

DOI:         Access: Open Access Read More

Author(s): Dharmendra Kumar Kushwah, Prakash Yashwant Kohle, Bimal Kumar Srivastava, Manoj Parmar ,Dhaval Mehta

DOI:         Access: Open Access Read More

Author(s): Rakesh P. Patel, Grishma Patel, Hitesh Patel , Ashok Baria

DOI:         Access: Open Access Read More

Author(s): Vidya N. Dange, Shubhangi J. Shid, Sagar B. Patil, Ganesh B. Vambhurkar, Mangesh A. Bhutkar

DOI: 10.5958/0975-4377.2019.00010.7         Access: Open Access Read More

Author(s): Isha Shah, Nensi Raytthatha, Jigar Vyas, Umesh Upadhyay

DOI: 10.52711/0975-4377.2021.00039         Access: Open Access Read More

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0975-4377 


Recent Articles




Tags