Author(s): Akshay R. Yadav, Shrinivas K. Mohite

Email(s): akshayyadav24197@gmail.com

DOI: 10.5958/0975-4377.2020.00042.7   

Address: Akshay R. Yadav*, Shrinivas K. Mohite
Department of Pharmaceutical Chemistry, Rajarambapu College of Pharmacy, Kasegaon, Maharashtra, India - 415404.
*Corresponding Author

Published In:   Volume - 12,      Issue - 4,     Year - 2020


ABSTRACT:
The search for new plant-derived drugs has gained renewed interest among researchers worldwide in the hunt for new drugs that have the potential to combat the threat of drug-resistant pathogenic microorganisms, antitumor and anticancer agents. Plants can be useful in either their crude or advanced forms, offering their pure state a source of drugs. Brine Shrimp Lethality Assay is the most convenient system to monitor the biological activity of different species of plants. This approach is very useful for the toxicity evaluation of plant extracts in advance. This assay has many advantages: rapidity, simplicity and low requirements. However, several requirements need to be fulfilled, especially with standardized experimental conditions (temperature, medium pH, salinity, aeration, and light). Psidiumguajava leaves have long been in use in the Indian Local Medicine System for their antioxidant and anti-inflammatory properties. The toxicity of Psidiumguajava leaf extracts using this assay was determined within a concentration range of 1mg/ml, 100µg/ml, 10µg/ml and 1µg/ml of the herbal extract being tested. After 24 hours of exposure to the studied sample, most toxicity studies using the Brine Shrimp Lethality Assay assess toxicity. The Brine Shrimp Lethality Assay is an excellent predictive tool for the toxic potential of plant extracts in humans.


Cite this article:
Akshay R. Yadav, Shrinivas K. Mohite. Toxicоlogical Evaluation of Psidium guajava Leaf Extracts using Brine Shrimp (Artemia salina L.) Model. Res. J. Pharma. Dosage Forms and Tech.2020; 12(4):258-260. doi: 10.5958/0975-4377.2020.00042.7

Cite(Electronic):
Akshay R. Yadav, Shrinivas K. Mohite. Toxicоlogical Evaluation of Psidium guajava Leaf Extracts using Brine Shrimp (Artemia salina L.) Model. Res. J. Pharma. Dosage Forms and Tech.2020; 12(4):258-260. doi: 10.5958/0975-4377.2020.00042.7   Available on: https://rjpdft.com/AbstractView.aspx?PID=2020-12-4-4


REFERENCES:
1.    Sahgal G, Ramanathan S, Sasidharan S. Brine Shrimp Lethality and Acute Oral Toxicity 0Studies on Swieteniamahagoni (Linn.) seed methanolic extract. Pharmacognosy Res. 2010; 2: 215-220.
2.    Ghosh P, Mandal A, Chakraborty P. Triterpenoids from Psidiumguajava with biocidal activity. Indian J Pharm Sci.2010;72(4):504-507.
3.    Kamba, A.S., Hassan. Antibacterial screening and Brine Shrimp (Artemiasalina) toxicity over Securidacalongepedunculata (Polygalaceae) root bark. AJPSP.2010; 1: 85-95.
4.    Kokkali V., Katramados, I., Newman, J. D. Monitoring the effect of metal ions on the mobility of Artemiasalinanauplii. Biosensors.2011; 1: 36-45.
5.    Lalisan, J.A., Nuñeza, O.M., Uy, M.M. Brine Shrimp (Artemiasalina) Bioassay of the medicinal plant Pseudelephantopusspicatus from Iligan City, Philippines. Int Res J Biol Sci. 2014; 3: 47-50.
6.    Maurer-Jones, M.A., Love, S.A. Meierhofer, S., Marquis, B.J., Liu, Z., Haynes, C.L., Toxicity of nanoparticles to brine shrimp: An introduction to nanotoxicity and interdisciplinary science. J ChemEdu.2013; 90: 475-478.
7.    Mayorga, P., Pérez, K.R., Cruz, S.M., Cáceres, A. Comparison of bioassays using the anostracan crustaceans Artemiasalina and Thamnocephalusplatyurus for plant extract toxicity screening. Bras J Pharm. 2010; 20: 897-903.
8.    Meyer, B.N., Ferrigni, N.R., Putnam, J.E., Jacobsen, L.B., Nichols, D.E., McLaughlin, J.L. Brine Shrimp: A convenient general bioassay for active plant constituents. PlantaMedica.1982; 45: 31-34.
9.    Michael, A.S., Thompson, C.G., Abramovitz, M. Artemiasalina as a test-organism for bioassay. Sci. 1956; 123: 464-465.
10.    Mirzaei, M., Mirzaei, A. Comparison of the Artemiasalina and Artemiauramiana bioassays for toxicity of 4 Iranian medicinal plants. Int Res J Biol Sci. 2013; 2: 49-54.
11.    Yadav A, Mohite S. Screening of In-vitro anti-inflammatory and Antibacterial assay of MalvastrumCoromandelianum. International Journal of Pharma Sciences and Research. 2020; 11(4): 68-70.
12.    Moshi, M.J., Innocent, E., Magadula, J.J., Otieno, D.F., Weisheit, A., Mbabazi, P.K., Nondo. Brine shrimp toxicity of some plants used as traditional medicines in Kagera Region, north western Tanzania. Tanz J H Res. 2010; 12: 63-67.
13.    Naidu, J.R., Ismail, R., Sasidharan, S. Acute Oral Toxicity and Brine Shrimp Lethality of Methanol Extract of Menthaspicata L. (Lamiaceae). Trop J Pharm Res.2014; 13: 101-107.
14.    Obembe, O.O., Oloyede, G.K., Raji, Y. Cytotoxicity and Acute Oral Toxicity Study on Quassin and Fractions ofQuassiaamara Extract. IJSBAR.2014; 13: 139-144.
15.    Parra, L.A., Yhebra, R.S., Sardiñas, I.G., Buela, L.I. Comparative study of the assay of Artemiasalina L. and the estimate of the medium lethal dose (LD50 value) in mice, to determine oral acute toxicity of plant extracts. Phytomed.2001; 8: 395-400.
16.    Pelka, M., Danzl, C., Distler, W., Petschelt, A. A new screening test for toxicity testing of dental materials. J Dent.2000; 28: 341-345.
17.    Pellosi, D.S., Batistela, V.R., Souza, V.R., Scarminio, I.S., Caetano, W., Hioka, N. Evaluation of the photodynamic activity of xanthene dyes on Artemiasalina described by chemometricapproaches. An Acad Bras Cienc.2013; 85: 1267-1274.
18.    Pimentel Montanher, A.B., Pizzolatti, M.G., Costa Brighente, I.M. An Application of the Brine Shrimp Bioassay for general screening of Brazilian medicinal plants.Acta Farm. Bonaerense. 2002; 21: 175-178.

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