Author(s): Mahua Bera, Suman Pattanayak, Lakshmi Kanta Kanthal, Lagnajit Mahapatra, Ayan Pani, Souranava Jana, Sonaram Pal, Suprabhat Das, Aniruddha Maity, Debjit Maity

Email(s): mahua.bera25@gmail.com

DOI: 10.52711/0975-4377.2023.00027   

Address: Mahua Bera*, Suman Pattanayak, Lakshmi Kanta Kanthal, Lagnajit Mahapatra, Ayan Pani, Souranava Jana, Sonaram Pal, Suprabhat Das, Aniruddha Maity, Debjit Maity
Haldia Institute of Pharmacy, Haldia, Purba Medinipur, West Bengal, India-721657.
*Corresponding Author

Published In:   Volume - 15,      Issue - 3,     Year - 2023


ABSTRACT:
Aceclofenac is an oxyacetic and non-steroidal anti-inflammatory drug which has a half-life of 4 h. Aceclofenac is used to reduce fever, inflammation of rheumatoid arthritis, traumatic pain etc. Aceclofenac has higher anti-inflammatory action than conventional NSAIDs. Development of aceclofenac microsphere is carried out to achieve sustained release of the drug after administration. The objective of this study was to find out the role of natural gum (Guar gum) for the preparation of microspheres. So, the amounts of natural gum were increased in various formulation at a successive rate. Aceclofenac microsphere is microencapsulated with guar gum and sodium alginate by Ionotropic gelation technique. There are various formulations of microspheres are developed. The prepared microspheres were spherical in shape, white in color and free flowing. Formulated microspheres were characterized for particle size, entrapment efficiency and in vitro drug release study. The aceclofenac microsphere showed particle size ranging from 330±10µm to 210±11µm 86.5% drug entrapment efficiency. The in vitro drug release is carried out up to 9 h in pH 6.8 phosphate buffer solution. F5 formulation showed maximum drug release of about 95.40% after 9 hour.


Cite this article:
Mahua Bera, Suman Pattanayak, Lakshmi Kanta Kanthal, Lagnajit Mahapatra, Ayan Pani, Souranava Jana, Sonaram Pal, Suprabhat Das, Aniruddha Maity, Debjit Maity. Preparation and Evaluation of Aceclofenac microsphere containing Natural gum.Research Journal of Pharmaceutical Dosage Forms and Technology. .2023; 15(3):163-8. doi: 10.52711/0975-4377.2023.00027

Cite(Electronic):
Mahua Bera, Suman Pattanayak, Lakshmi Kanta Kanthal, Lagnajit Mahapatra, Ayan Pani, Souranava Jana, Sonaram Pal, Suprabhat Das, Aniruddha Maity, Debjit Maity. Preparation and Evaluation of Aceclofenac microsphere containing Natural gum.Research Journal of Pharmaceutical Dosage Forms and Technology. .2023; 15(3):163-8. doi: 10.52711/0975-4377.2023.00027   Available on: https://rjpdft.com/AbstractView.aspx?PID=2023-15-3-3


REFERENCES:
1.    Vinod R, Kumar PA, Yadav AS, Rao BS, Kulkarni SV. Formulation and Evaluation of Controlled Release Microspheres of Zidovudine. Research Journal of Pharmaceutical Dosage Forms and Technology. 2010; 2(1):96-9.
2.    Prasanth V, MoyA, Mathew S, Mathappan R. Microspheres- An overview. International Journal of Research in Pharmaceutical and Biomedical Sciences. 2011; 2. 332-338.
3.    Kavita K, Ashvini VR, Ganesh NS. Albumin microspheres. Unique system as drug delivery carriers for nonsteroidalanti inflammatory drugs. Int J Pharm Sci Rev Res. 2010; 5(2):10.
4.    Singh C, Purohit S, Singh M, Pandey BL. Design and evaluation of microspheres: A Review. Journal of Drug Delivery Research. 2013; 2(2):18-27.
5.    Chandy A, Rai S, Manigauha A, Sahu S. Entric-Coated Pectin Microspheres of Indomethacin for Targeting Inflammation in Lower Gastro intestinal tract. Research Journal of Pharmaceutical Dosage Forms and Technology. 2009; 1(1):29-32.
6.    Kamaly N, Yameen B, Wu J, Farokhzad OC. Degradable controlled-release polymers and polymeric nanoparticles: mechanisms of controlling drug release. Chemical Reviews. 2016 Feb 24; 116(4):2602-63.
7.    Venkatesan P, Manavalan R, Valliappan K. Microencapsulation: a vital technique in novel drug delivery system. Journal of Pharmaceutical Sciences and Research. 2009 Dec 1; 1(4):26-35.
8.    Khan H, Ali J. Formulation and evaluation of sustained release matrix tablets containing aceclofenac and paracetamol. Research Journal of Pharmaceutical Dosage Forms and Technology. 2017; 9(2):48-52.
9.    Ahmad W, Jawed R. Design and Characterization of Sustained Released Alginate Beads of Meclizine Hydrochloride. Research Journal of Pharmaceutical Dosage Forms and Technology. 2022 Jul 1; 14(3):199-205.
10.    Karmakar U, Faysal MM. Diclofenac as microspheres. The Internet Journal of Third World Medicine. 2009; 8(1).
11.    Chandy A, Rai S, Manigauha A, Sahu S. Entric-Coated Pectin Microspheres of Indomethacin for Targeting Inflammation in Lower Gastro intestinal tract. Research Journal of Pharmaceutical Dosage Forms and Technology. 2009; 1(1):29-32.
12.    Gudsoorkar VR, Rambhau D. Sustained release of drugs. Eastern Pharmacist. 1993; 36:17-.
13.    Dupinder K, Seema S, Gurpreet S, Rana AC. Biodegradable microspheres: A review. IRJP. 2012; 3(12):23-7.
14.    Saralidze K, Koole LH, Knetsch MLW. Polymeric Microspheres for Medical Applications. Materials (Basel). 2010 Jun 7; 3(6):3537–64
15.    Jha MK. Modified release formulations to achieve the quality target product profile (QTPP). International Journal of Pharmaceutical Sciences and Research. 2012 Aug 1; 3(8):2376.
16.    Gavali KV, Kengar MD, Chavan KV, Anekar VP, Khan NI. A Review on Microsphere and it's Application. Asian Journal of Pharmaceutical Research. 2019; 9(2):123-9.
17.    Srivastava P, Visht S. Application and advancement of microsphere as controlled delivery system: A review. International Journal of Pharmacy and Life Sciences. 2013 Apr 1; 4(4).
18.    Fu X, Ping Q, Gao Y. Effects of formulation factors on encapsulation efficiency and release behaviour in vitro of huperzine A-PLGA microspheres. Journal of Microencapsulation. 2005 Jan 1; 22(7):705-14.
19.    Mukherjee S, Bandyopadhyay P. Magnetic microspheres: a latest approach in novel drug delivery system. J Pharm Sci Innovation. 2012; 26:21-5.
20.    Batra  D,  Kakar  S,  Singh  R,  Nautiyal  U.  Magnetic microspheres  as  a  targeted  drug  delivery  system:An overview. JDDR, 2012, 1(3), 1-17
21.    Sahu G, Sharma H, Kaur CD. A novel approach of magnetic modulated microspheres. Asian Journal of Pharmaceutical Research. 2013; 3(4):220-4.
22.    Mahanur V, Sureka Y, Atole V. A Review on Magnetic Microspheres-A Novel Drug Delivery System.Asian Journal of Research in Pharmaceutical Sciences. 2022; 12(1):57-1.
23.    Patra CN, Dutta P, Sruti J, Rao MB. Floating microspheres: recent trends in the development of gastroretentive floating drug delivery system. International Journal of Pharmaceutical Sciences and Nanotechnology. (IJPSN). 2011 May 31; 4(1):1296-306.
24.    Kawatra M, Jain U, Ramana J. Recent advances in floating microspheres as gastro-retentive drug delivery system: A review. Int J Recent Adv Pharm Res. 2012; 2(3):5-23.
25.    Ajit VK, Arun GK, Piush K, Rakesh P. Formulation and Development of Floating Microspheres containing Levodopa and Carbidopa. Asian Journal of Pharmacy and Technology. 2018; 8(4):200-2.
26.    Kawatra M, Jain U, Ramana J. Recent advances in floating microspheres as gastro-retentive drug delivery system: A review. Int J Recent Adv Pharm Res. 2012; 2(3):5-23.
27.    Singh C, Purohit S, Singh M, Pandey BL. Design and evaluation of microspheres: A Review. Journal of Drug Delivery Research. 2013; 2(2):18-27.
28.    Shah RS, Shah RR, Nitalikar MM, Magdum CS. Microspheres by spray drying: An approach to enhance solubility of Bicalutamide. Asian Journal of Pharmaceutical Research. 2017; 7(3):183-8.
29.    Murillo M, Gamazo C, Goñi MM, Irache JM, Blanco-Prı́eto MJ. Development of microparticles prepared by spray-drying as a vaccine delivery system against brucellosis. International Journal of Pharmaceutics. 2002 Aug 21; 242(1-2):341-4.
30.    Katou H, Wandrey AJ, Gander B. Kinetics of solvent extraction/evaporation process for PLGA microparticle fabrication. International Journal of Pharmaceutics. 2008 Nov 19; 364(1):45-53.
31.    Vasavi A, Mrunalini M, Vasanthi A, Babu GR, Sowjanya M. Formulation and Evaluation of Sustained Release Stavudine Microspheres by Ionotropic Gelation Method. Asian Journal of Pharmacy and Technology. 2022 May 25; 12(2):119-24.
32.    Ramteke KH, Jadhav VB, Dhole SN. Microspheres: as carrieres used for novel drug delivery system. Iosrphr. 2012 Jul; 2(4):44-8.
33.    Nakagawa S, Yoshie N. Star polymer networks: a toolbox for cross-linked polymers with controlled structure. Polymer Chemistry. 2022; 13(15):2074-107.
34.    K. Dupinder K, Seema S, Gurpreet S, Rana AC. Biodegradable microspheres: A review. IRJP. 2012; 3(12):23-7.
35.    Saralidze K, Koole LH, Knetsch MLW. Polymeric Microspheres for Medical Applications. Materials (Basel). 2010 Jun 7; 3(6):3537–64.

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