Research Journal of Pharmaceutical Dosage Forms and Technology

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0975-4377 (Online)
0975-234X (Print)


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Effect of pH on Dissolution Profile of Atenolol Sustained Release Matrix Tablets

Author(s): Masheer Ahmed Khan

Email(s): masheerak@yahoo.com.

DOI: Not Available

Address: Masheer Ahmed Khan*
School of Pharmacy, Devi Ahilya Vishwavidyalaya,Takshshila Campus, Khandwa Road, Indore, 452001, India.
*Corresponding Author

Published In:   Volume - 5,      Issue - 5,     Year - 2013

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ABSTRACT:
The present study was performed to illustrate the effect of pH on dissolution profile of atenolol sustained release matrix tablets. Atenolol is ß-1 cardio selective adrenergic receptor blocker, widely used in the treatment of hypertension. The drug is insoluble in water and has half-life of six to eight hours with oral bioavailability of 50% due to smaller dose of drug (less than 50 mg). Once daily Sustained release matrix tablets of Atenolol reduces the frequency of administration and improves the patient compliance. Atenolol matrices were prepared from combination of polymers HPMCK4M and HPMCK15M to sustain the release of the drug. Multimedia dissolution studies were performed to mimic the in-vivo condition by doing in-vitro test and pH/buffer selection is based on the exposure of drug from stomach to intestine/colon and to ensure the impact of pH changes on dissolution and release of drug substance for absorption. The study ensures the impact of pH changes on dissolution and release of drug substance for absorption.


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Cite this article:
Masheer Ahmed Khan. Effect of pH on Dissolution Profile of Atenolol Sustained Release Matrix Tablets. Research J. Pharma. Dosage Forms and Tech. 2013; 5(5): 274-276.

Cite(Electronic):
Masheer Ahmed Khan. Effect of pH on Dissolution Profile of Atenolol Sustained Release Matrix Tablets. Research J. Pharma. Dosage Forms and Tech. 2013; 5(5): 274-276.   Available on: https://rjpdft.com/AbstractView.aspx?PID=2013-5-5-6


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Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. The aim of RJPDFT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPDFT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical Chemistry, Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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