Formulation and Evaluation Flurbiprofen Solid Dispersion for Solubility and Dissolution Enhancement

Ravindra M Hanwate

doi:10.52711/0975-4377.2026.00004

Research Journal of Pharmaceutical Dosage Forms and Technology

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0975-4377 (Online)
0975-234X (Print)

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Formulation and Evaluation Flurbiprofen Solid Dispersion for Solubility and Dissolution Enhancement

Author(s): Ravindra M Hanwate

Email(s): ravi_hanwate@yahoo.co.in

DOI: 10.52711/0975-4377.2026.00004

Address: Ravindra M Hanwate*
Associate Professor, Oyster Institute Pharmacy, Chh. Sambhajinagar 431201, Maharashtra, India.
*Corresponding Author

Published In: Volume - 18, Issue - 1, Year - 2026

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ABSTRACT:
The main purpose of this research is to enhance the solubility and how fast the drug Flurbiprofen dissolves in water. This drug is accustomed to use swelling and pain and is not extremely solvable in water. To assist with this, the drug was created into a solid dispersion utilize distinct kind of hydrophilic polymers. The investigation seems at how well the drug dissolved in numerous polymers like PVP-K30, HPMC, and PEG 6000. Five distinctive solid dispersion formulations were made using the solvent evaporation method along with varied polymers. Each formulation was tested for particle size, how much drug was in the formulation, and how well it dissolved in water. Based on these tests, the best formulation was SD5. The formulation SD5, which used Flurbiprofen, and sodium lauryl sulfate in a ratio of 1:5:2, showed the fastest drug release, with 99.86% released within 15 minutes. Also, the solubility of the drug in SD5 was 44 times better than the solubility of the pure drug. To coincide if the drug and the other ingredients worked well together, FTIR and XRD tests were done. The results showed that the drug and the polymers were compatible, and the best formulation had an amorphous structure, which helped the drug dissolve better than the pure drug. This shows that using this method can help increase the body's ability to absorb the drug, which is important for drugs that don't dissolve well in water.

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Cite this article:
Ravindra M Hanwate. Formulation and Evaluation Flurbiprofen Solid Dispersion for Solubility and Dissolution Enhancement. Research Journal of Pharmaceutical Dosage Forms and Technology.2026; 18(1):23-7. doi: 10.52711/0975-4377.2026.00004

Cite(Electronic):
Ravindra M Hanwate. Formulation and Evaluation Flurbiprofen Solid Dispersion for Solubility and Dissolution Enhancement. Research Journal of Pharmaceutical Dosage Forms and Technology.2026; 18(1):23-7. doi: 10.52711/0975-4377.2026.00004 Available on: https://rjpdft.com/AbstractView.aspx?PID=2026-18-1-4

REFERENCES:
1. M H Dehghan R M Hanwate, M Saifee. Comparative dissolution study of Glipizide by solid dispersion. ch J. Pharm Sci. and Tech. 2010; 9(2): 293-297
2. Sneha Jagtap, Chandrakant Magdum, Rajesh Jagtap. Ameliorated Solubility and Dissolution of Flurbiprofen using Solubilizer Sepitrap 80 and Sepitrap 4000. Research J. Pharm. and Tech. 2021; 14(1): 21-27. doi: 10.5958/0974-360X.2021.00005.6
3. Punitha S, Srinivasa Reddy G, Srikrishna T, Lakshman Kumar M. Solid Dispersions: A Review. Research J. Pharm. and Tech. 2011; 4(3): 331-334.
4. Ranim Alrouhayyah, Tatiana F. Sheshko, Svetlana N. Suslina, Omran Aisha. Solid Dispersions: An Effective Technology for Improving Dissolution Kinetics of Poorly Soluble Drugs. Research Journal of Pharmacy and Technology. 2023; 16(12): 5701-6. doi: 10.52711/0974-360X.2023.00922
5. Komal Chandrakant Jadhav, Sourabh Sukumar Hegaje, Sadhana Uttam Jadhav, Rupesh Sopanrao Vaidhya, Mayuresh Ramesh Redkar. Formulation and Evaluation of Solid Dispersion of Poorly Soluble Drugs. Asian Journal of Pharmacy and Technology; 12(4): 309-2. doi: 10.52711/2231-5713.2022.00050
6. Hassnain F, Bashir S, Asad M, Nazir I, Qamar S, Imran M, et al. Formulation and characterization of solid dispersion of nisoldipine by solvent evaporation method. J Pharm Altern Med 2012; 2:21-8.
7. Smita Kolhe, Praveen Chaudhari, Dhananjay More. Formulation Development of Solid Dispersion Prepared by Newer Approach: A Research. Asian J. Pharm. Res. 2013; 3(4): 172-180.
8. Lakshmi K, Kumarreddy MP, Kaza R. Dissolution enhancement of telmisartan by surface solid dispersion technology. Int J Innov Pharm Res 2012; 3: 247-51.
9. Daravath B, Naveen C, Vemula SK, Tadikonda RR. Solubility and dissolution enhancement of flurbiprofen by solid dispersion using hydrophilic carriers. Braz J Pharm Sci. 2017; 53: e00010.
10. Enose AA, Dasan P, Sivaramakrishanan H, Kakkar V. Formulation characterization and pharmacokinetic evaluation of telmisartan solid dispersions. J Mol Pharm Org Process Res. 2016; 4: 131.
11. Patil A, Kumar S. Formulation and evaluation of solid dispersions of an anthelmintic drug for enhancement of dissolution rate. JIPBS. 2017; 4:71-4.
12. Vippagunta SR, Maul KA, Tallavajhala S, Grant DJ. Solid state characterization of nifedipine solid dispersions. Int J Pharm. 2002; 236:111-23

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