Research Journal of Pharmaceutical Dosage Forms and Technology

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0975-4377 (Online)
0975-234X (Print)


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Formulation and Evaluation of Aceclofenac-loaded Nanoparticles by Solvent Evaporation Method

Author(s): Suman Kumar Rathore, Brajesh Kumar Pathak

Email(s): sumanpharm123@gmail.com , brejesh.pathak@gmail.com

DOI: 10.5958/0975-4377.2020.00039.7   

Address: Suman Kumar Rathore, Brajesh Kumar Pathak
Mittal Institute of Pharmacy, Bhopal (M.P.)
*Corresponding Author

Published In:   Volume - 12,      Issue - 4,     Year - 2020

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ABSTRACT:
Nanoparticles have applications in the formulation of poorly water soluble drugs to improve their bioavailability. Preparation and evaluation aceclofenac-loaded nanoparticles by solvent evaporation method to enhance solubility and bioavailability were the primary aim of the present investigation. Nanoparticles of aceclofenac, a BCS class II drug were prepared by solvent evaporation technique and characterized using Fourier transform infrared spectroscopy, particle size and zeta potential, scanning electron microscopy and drug release studies in vitro. Data from the Fourier-transform infrared spectroscopy showed no interaction between drug and the polymers. Scanning electron microscopy images indicated that nanoparticles were spherical in shape. Water solubility of drug-loaded nanoparticles was increased as compared to the pure drug and showed improved dissolution profile, which indicated that nanoprecipitation, was simple and precise. This laboratory scale method as well as this approach could be employed for solubility and bioavailability improvement of aceclofenac.


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Cite this article:
Suman Kumar Rathore, Brajesh Kumar Pathak. Formulation and Evaluation of Aceclofenac-loaded Nanoparticles by Solvent Evaporation Method. Res. J. Pharma. Dosage Forms and Tech.2020; 12(4):237-244. doi: 10.5958/0975-4377.2020.00039.7

Cite(Electronic):
Suman Kumar Rathore, Brajesh Kumar Pathak. Formulation and Evaluation of Aceclofenac-loaded Nanoparticles by Solvent Evaporation Method. Res. J. Pharma. Dosage Forms and Tech.2020; 12(4):237-244. doi: 10.5958/0975-4377.2020.00039.7   Available on: https://rjpdft.com/AbstractView.aspx?PID=2020-12-4-1


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Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. The aim of RJPDFT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPDFT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical Chemistry, Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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