Research Journal of Pharmaceutical Dosage Forms and Technology

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0975-4377 (Online)
0975-234X (Print)


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Linezolid Loaded Biodegradable Polymeric Nanoparticles Formulation and Characterization

Author(s): Jessy Shaji, Monika Kumbhar

Email(s): jessy.shaji@gmail.com

DOI: 10.5958/0975-4377.2018.00040.X   

Address: Jessy Shaji*, Monika Kumbhar
Department of Pharmaceutics, Prin. K. M. Kundnani College, of Pharmacy, Cuffe Parade, Colaba Mumbai.400005
*Corresponding Author

Published In:   Volume - 10,      Issue - 4,     Year - 2018

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ABSTRACT:
After HIV, Tuberculosis(TB) is the second lethal disease on the globe. In this present study, double emulsion solvent evaporation method was used to formulate Linezolid loaded biodegradable PLGA polymeric nanoparticles (LZD-PNPs). Poly[D,L-Lactic-co-glycolic acid] 50:50 was used as a biodegradable polymer, Tween 80 as a non-ionic surfactant and PVA was used as a co-polymer or stabilizer.Design-expert® v.11.0.5.0 software was used for optimization of LZD-PNPs. Particle size distribution and entrapment efficiency were the main two factors considered for optimization of LZD loaded polymeric formulation. Preformulation studies and characterization of the optimized batch were carried out by Fourier Transfer Infrared Spectroscopy (FT-IR), Differential Scanning Calorimetry (DSC) and Scanning Electron Microscopy (SEM) analysis. The mean particle size of LZD loaded PNPs optimized batch was found to be at 75nm with ±22 SD and was monodispersed. Entrapment efficiency of optimised batch was calculated by indirect method & found to be 87.64%. Physicochemical Stability of LZD loaded PNPs formulations were confirmed by zeta potential analysis and was found to be -32mv which indicates stability of the formulation.In vitro drug release study was carried out using dialysis bag method. The cumulative percentage drug releasewas found to be 92.34±1.37 for 24 hours. SEM studies revealed that formulated LZD polymeric nanoparticle have spherical morphology, smooth texture, and LZD was successfully coated by Biodegradable PLGA polymer.


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Cite this article:
Jessy Shaji, Monika Kumbhar. Linezolid Loaded Biodegradable Polymeric Nanoparticles Formulation and Characterization. Res. J. Pharm. Dosage Form. & Tech. 2018; 10(4): 272-278. doi: 10.5958/0975-4377.2018.00040.X

Cite(Electronic):
Jessy Shaji, Monika Kumbhar. Linezolid Loaded Biodegradable Polymeric Nanoparticles Formulation and Characterization. Res. J. Pharm. Dosage Form. & Tech. 2018; 10(4): 272-278. doi: 10.5958/0975-4377.2018.00040.X   Available on: https://rjpdft.com/AbstractView.aspx?PID=2018-10-4-9


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DOI: 10.5958/0975-4377 

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Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. The aim of RJPDFT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPDFT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical Chemistry, Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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