Linezolid Loaded Biodegradable Polymeric Nanoparticles Formulation and Characterization

Jessy Shaji; Monika Kumbhar

doi:10.5958/0975-4377.2018.00040.X

Research Journal of Pharmaceutical Dosage Forms and Technology

ISSN

0975-4377 (Online)
0975-234X (Print)

Submit Article

Linezolid Loaded Biodegradable Polymeric Nanoparticles Formulation and Characterization

Author(s): Jessy Shaji, Monika Kumbhar

Email(s): jessy.shaji@gmail.com

DOI: 10.5958/0975-4377.2018.00040.X

Address: Jessy Shaji*, Monika Kumbhar
Department of Pharmaceutics, Prin. K. M. Kundnani College, of Pharmacy, Cuffe Parade, Colaba Mumbai.400005
*Corresponding Author

Published In: Volume - 10, Issue - 4, Year - 2018

View HTML

Purchase PDF

ABSTRACT:
After HIV, Tuberculosis(TB) is the second lethal disease on the globe. In this present study, double emulsion solvent evaporation method was used to formulate Linezolid loaded biodegradable PLGA polymeric nanoparticles (LZD-PNPs). Poly[D,L-Lactic-co-glycolic acid] 50:50 was used as a biodegradable polymer, Tween 80 as a non-ionic surfactant and PVA was used as a co-polymer or stabilizer.Design-expert® v.11.0.5.0 software was used for optimization of LZD-PNPs. Particle size distribution and entrapment efficiency were the main two factors considered for optimization of LZD loaded polymeric formulation. Preformulation studies and characterization of the optimized batch were carried out by Fourier Transfer Infrared Spectroscopy (FT-IR), Differential Scanning Calorimetry (DSC) and Scanning Electron Microscopy (SEM) analysis. The mean particle size of LZD loaded PNPs optimized batch was found to be at 75nm with ±22 SD and was monodispersed. Entrapment efficiency of optimised batch was calculated by indirect method & found to be 87.64%. Physicochemical Stability of LZD loaded PNPs formulations were confirmed by zeta potential analysis and was found to be -32mv which indicates stability of the formulation.In vitro drug release study was carried out using dialysis bag method. The cumulative percentage drug releasewas found to be 92.34±1.37 for 24 hours. SEM studies revealed that formulated LZD polymeric nanoparticle have spherical morphology, smooth texture, and LZD was successfully coated by Biodegradable PLGA polymer.

Keywords:

Cite this article:
Jessy Shaji, Monika Kumbhar. Linezolid Loaded Biodegradable Polymeric Nanoparticles Formulation and Characterization. Res. J. Pharm. Dosage Form. & Tech. 2018; 10(4): 272-278. doi: 10.5958/0975-4377.2018.00040.X

Recomonded Articles:

Isolation and evaluation of Basella alba linn. Leaf mucilage as release retardant in tablet formulation

Author(s): Yamunappa, Ravi Kumar, Pooja Shetty, Prathibha Suvarna, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00012.4 Access: Open Access Read More

Formulation Development and Evaluation of Capsule Containing Fluclaxacillin Sodium and Amoxicillin Trihydrate with Enteric Coated Granules of Lactic Acid Bacillus

Author(s): Gopal Rao M., M. A. Amutha Gnana Arasi, S. Jayaprakash, M. Arun Kumar, P. Kavitha

DOI: Access: Open Access Read More

Formulation and Evaluation of Fast Dissolving Tablets of Trimetazidine Dihydrochloride Using Natural and Synthetic Superdisintegrants

Author(s): Simila Madathil, RaviKumar, Anju Govind, Mercy Mathew, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00013.6 Access: Open Access Read More

Comparative Standardization of Two Marketed Preparation of Gulwel churna

Author(s): Swati Talokar, Rohan R Vakhariya, A.R Dhole

DOI: 10.5958/0975-4377.2017.00005.2 Access: Open Access Read More

Formulation Development and Evaluation of Buccal Patches of Aceclofenac for Gingivitis

Author(s): Puja Saha, Pratik Swarup Das

DOI: 10.5958/0975-4377.2017.00026.X Access: Open Access Read More

Formulation and Evaluation of Transdermal Patch of Aceclofenac

Author(s): Rakesh P. Patel, Grishma Patel, Hitesh Patel , Ashok Baria

DOI: Access: Open Access Read More

Formulation and Optimization of Metoprolol Succinate Sublingual Tablet by Statistical Optimization Technique

Author(s): Priya Patel, NiravJani, NavinSheth, Paresh Patel

DOI: 10.5958/0975-4377.2015.00006.3 Access: Open Access Read More

Microemulsion: A Current Review

Author(s): Sushant R. Jagtap, D.G Phadtare, R.B. Saudagar

DOI: 10.5958/0975-4377.2016.00021.5 Access: Open Access Read More

Formulation and Evaluation of Immediate Release Pravastatin Sodium Tablets

Author(s): Yamunappa, Ravi Kumar, Pooja Shetty, Prathibha Suvarna, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00014.8 Access: Open Access Read More

Formulation and Evaluation of Israpidine Extended Release Matrix Tablets

Author(s): Praveen Kumar Uppala, K. Atchuta Kumar, Murali Krishna, U. Upendra Rao

DOI: 10.5958/0975-4377.2016.00039.2 Access: Open Access Read More

Formulation and Evaluation of Buccal Tablet of Rasagiline Mesylate

Author(s): Shilpa N. Shrotriya, Kishore N. Gujar, Bhakti R. Chorghe

DOI: Access: Open Access Read More

Formulation and Evaluation of Diclofenac Suspension by Using Natural Suspending Agents

Author(s): Sayad Basha.K, Sheema Nafees. S, Nethravani. G, Thirumalesh Naik S.B

DOI: 10.5958/0975-4377.2016.00015.X Access: Open Access Read More

Formulation and Evaluation of Floating Matrix Tablets of Acyclovir using 32 Factorial Design

Author(s): Swati Rawat, Shradha Sangali, Akhilesh Gupta

DOI: 10.5958/0975-4377.2018.00001.0 Access: Open Access Read More

Formulation, In Vitro Release and Iontophoresis Study of Fluconazole Hydrogel

Author(s): Ashok A Hajare, Mahesh N Mali, Arun S Dange, Sushil M Sarvagod, Shweta V Patwardhan ,Sachin T Kurane

DOI: Access: Open Access Read More

Formulation and characterization of Virgin Coconut Oil Emulsion (VCOE) for treatment of Alzheimer’s disease

Author(s): Shubham Tripathi, Umesh kumar Sahu, JyotsanaMeshram, RanjeetaKumari, D.K Tripathi, Ajazuddin, Amit Alexander, Harish Sharma, Gyanesh Kumar Sahu

DOI: 10.5958/0975-4377.2018.00009.5 Access: Open Access Read More

Formulation and Evaluation of Effervescent Floating Tablets of Procainamide

Author(s): B. Saraswathi, R. Jagadeesh Reddy, P. Swathi, G. Manasa

DOI: 10.5958/0975-4377.2017.00025.8 Access: Open Access Read More

Formulation and Evaluation of mucoadhesive buccal patches of Terbutaline Sulphate

Author(s): Suresh A. Marnoor

DOI: Access: Open Access Read More

Glimepiride Micro balloons: A Novel Approach for Bioavailability Enhancement by Gastro-Retentive Floating Drug Delivery System

Author(s): Rutuja R. Shah, Rutuja S. Shah, Rohan R. Vakhariya

DOI: 10.5958/0975-4377.2017.00030.1 Access: Open Access Read More

A Short Review on the Formulation of Transdermal Dermal Drug Delivery System (TDDS)

Author(s): Alok Ranjan, Aishwarya Sahu, Akansha Yadav, Alka Payasi, Akash Jaiswal, Akshay Kumar, Akash Sahu, Ashwani Jangde, Chandrashekhar Nayak, Dev Kumar, Harshita Yarda, Mitali Sahu, Nokesh Sahu, Rajesh Patel, Nisha Nair, Mukta Agrawal, Ajazuddin, D. K. Tripathi, Amit Alexander

DOI: 10.5958/0975-4377.2018.00014.9 Access: Open Access Read More

Evaluation of Seed Mucilage of Hibiscus Sabdariffa Linn as Tablet Binder

Author(s): Ch. Anupama, P. Padmakumari, K. Abbulu, Arti Mohan, A. Ppratyusha

DOI: Access: Open Access Read More

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

RNI: Not Available
DOI: 10.5958/0975-4377