Silk Fibroin: A Boon to Pharmaceutical and Biomedical Applications

Kiran R. Birajdar; Satish K. Mandlik

doi:10.5958/0975-4377.2017.00015.5

Research Journal of Pharmaceutical Dosage Forms and Technology

ISSN

0975-4377 (Online)
0975-234X (Print)

Submit Article

Silk Fibroin: A Boon to Pharmaceutical and Biomedical Applications

Author(s): Kiran R. Birajdar, Satish K. Mandlik

Email(s): kiran.birajdar369@gmail.com

DOI: 10.5958/0975-4377.2017.00015.5

Address: Kiran R. Birajdar*, Satish K. Mandlik
Department of Pharmaceutics, STES’s Sinhgad College of Pharmacy, Vadgaon (Bk.), Pune - 411041 (M.S.) India
*Corresponding Author

Published In: Volume - 9, Issue - 3, Year - 2017

View HTML

View PDF

ABSTRACT:
Silks are naturally occurring polymers that have been used clinically as sutures for centuries. When naturally extruded from insects or worms, silk is composed of a filament core protein, termed fibroin. To date fibroin from Bombyxmori silk worm has been the dominant source for silk-based biomaterials studied. Silk fibroin (SF) is a naturally occurring protein polymer with several unique properties that make it a suitable material for incorporation into a variety of drug delivery vehicles capable of delivering a range of therapeutic agents. SF is biocompatible, slowly biodegradable, and endowed with excellent mechanical properties and process ability. So far, the main focus of SF drug delivery systems has been on tissue regeneration applications. For instance, growth factor loaded SF scaffolds were suggested for the tissue engineering of bone and cartilage, as well as for vascular and nerve regeneration devices and wound healing products. Moreover, SF matrices were proposed for oral, transmucosal and ocular drug delivery. SF matrices have been shown to successfully deliver anticancer drugs, small molecules, and biomolecules. This article will provide an in-depth discussion on the SF properties and pharmaceutical and drug delivery applications of Silk fibroin in nanoparticles.

Keywords:

Cite this article:
Kiran R. Birajdar, Satish K. Mandlik. Silk Fibroin: A Boon to Pharmaceutical and Biomedical Applications. Res. J. Pharm. Dosage Form. & Tech. 2017; 9(3): 85-92. doi: 10.5958/0975-4377.2017.00015.5

Cite(Electronic):
Kiran R. Birajdar, Satish K. Mandlik. Silk Fibroin: A Boon to Pharmaceutical and Biomedical Applications. Res. J. Pharm. Dosage Form. & Tech. 2017; 9(3): 85-92. doi: 10.5958/0975-4377.2017.00015.5 Available on: https://rjpdft.com/AbstractView.aspx?PID=2017-9-3-1

Recomonded Articles:

Factorial Designing for Pharmaceutical Product and Process Development

Author(s): Vinod K.R., Sandhya S

DOI: Access: Open Access Read More

Pharmaceutical Suspensions: Pharmacist has the Very Best Possible Formulation for the Job at Hand.

Author(s): Praneta Desale

DOI: Access: Open Access Read More

Formulation, Evaluation of Clotrimazole Vaginal Suppository

Author(s): V. S. Parmar, S.C. Shivhare

DOI: Access: Open Access Read More

Cleaning Validation of Paracetamol Tablets as a Dosage Formulation

Author(s): Hapse S.A., Bhagat B.V., Wagh V.S. , Kadaskar P.T.

DOI: Access: Open Access Read More

Formulation and Evaluation of Tolperisone Hydrochloride Sustained Release Tablet

Author(s): Domendra Sahu, Shekhar Verma , Ravindra D. Dubey

DOI: Access: Open Access Read More

Pharmaceutical Packaging Technology: A Brief Outline

Author(s): Pratik Swarup Das, Puja Saha1, Krishan, Rumpa Das

DOI: :10.5958/0975-4377.2018.00005.8 Access: Open Access Read More

A Brief Review on Intra-Uterine Drug Delivery Systems

Author(s): Suyash Ingle, Varsha Tegeli, Akshay Javalgikar, Vinod Matole, Lagmanna koli, Avinash Birajdar, Saurabh Nangare, Sagar Adlinge, Swaminath Ramanshetti, Akhil Patil, Yash Kothari, Pandurang Choure, Aaqueeb Mangalgiri, Sneha Ubale, Vaishnavi Dulange, Bhavana habib, Jyoti Mittha

DOI: 10.5958/0975-4377.2021.00013.6 Access: Open Access Read More

Transdermal Drug Delivery System of Antidiabetic Drugs: A Review

Author(s): Swapnil T. Deshpande, P. S. Vishwe, Rohit D. Shah, Swati S. Korabu, Bhakti R. Chorghe, DG Baheti

DOI: Access: Open Access Read More

Formulation and Evaluation of Stable Montelukast Sodium Sublingual Tablet by using Lyophilization Technique

Author(s): Dipti G. Phadtare, Amol R. Pawar, R.B. Saudagar, Govind K.Patil

DOI: 10.5958/0975-4377.2017.00002.7 Access: Open Access Read More

Isolation and evaluation of Basella alba linn. Leaf mucilage as release retardant in tablet formulation

Author(s): Yamunappa, Ravi Kumar, Pooja Shetty, Prathibha Suvarna, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00012.4 Access: Open Access Read More

Formulation and Evaluation of Solid Lipid Nanoparticle Based Transdermal Drug Delivery System for Alzheimer’s Disease

Author(s): Pramod Salve, Suvarna Pise, Nikhil Bali

DOI: 10.5958/0975-4377.2016.00011.2 Access: Open Access Read More

Formulation and Evaluation of Fast Dissolving Tablets of Trimetazidine Dihydrochloride Using Natural and Synthetic Superdisintegrants

Author(s): Simila Madathil, RaviKumar, Anju Govind, Mercy Mathew, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00013.6 Access: Open Access Read More

A Validated Method for the Estimation of EDTA in Drug Substances and their Intermediates by using Reversed Phase High Performance Liquid Chromatography

Author(s): Dharmendra Kumar Kushwah, Prakash Yashwant Kohle, Bimal Kumar Srivastava, Manoj Parmar ,Dhaval Mehta

DOI: Access: Open Access Read More

Self Microemulsifying Drug Delivery System (SMEDDS): A Novel Approach to Improve the Therapeutic Efficacy of Orally Administered Drug

Author(s): Kritika Kanoujia, Chandraprabha Dewangan, Ayushi Masih, Dipti Sinha, Divya Oraon, Manisha Jaiswal, Monika Sahu, Ranjeeta Kumari, Sapna Pradhan, Ravi Suman, Rajkishan Dewangan, Roman Banjare, Pradeep Paikra, Mukesh Rawtiya, Mukta Agrawal, Ajazuddin, D. K. Tripathi, Amit Alexander

DOI: 10.5958/0975-4377.2018.00015.0 Access: Open Access Read More

ORPHAN DRUGS - ITS PROS AND CONS

Author(s): Debarupa Dutta, Prithviraj Chakraborty

DOI: Access: Open Access Read More

Sensitive Visible Spectrophotometric methods Development for Estimation of Sapropterin Dihydrochloride in tablet dosage form

Author(s): U. Viplava Prasad, M. Syam Bab, B. Kalyana Ramu

DOI: 10.5958/0975-4377.2017.00007.6 Access: Open Access Read More

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

RNI: Not Available
DOI: 10.5958/0975-4377