Author(s): Suman Kumar Rathore, Mohammad Akhtar Rasool, Mohammad Ayazuddin Farooqui, Yogesh Pounikar

Email(s): Sumanpharm123@gmail.com

DOI: 10.52711/0975-4377.2026.00032   

Address: Suman Kumar Rathore1*, Mohammad Akhtar Rasool2, Mohammad Ayazuddin Farooqui3, Yogesh Pounikar4
1,3Research Scholar Ph. D, Bhagwant University, Ajmer, Rajasthan, India.
2Tagore Institute of Pharmacy and Research, Sakri, Bilaspur, Chhattisgarh, India.
4J.K. College of Pharmacy, Near Gatora Railway Station, Bilaspur, Chhattisgarh, India.
*Corresponding Author

Published In:   Volume - 18,      Issue - 3,     Year - 2026


ABSTRACT:
Tridax procumbens (L.) R.Br. ex Griseb., often called Coat buttons or Tridax daisy is a perennial herb of the Asteraceae family that has been widely used in traditional medicine systems in many cultures, especially in India, Africa and Latin America. Due to its plentiful phytochemical content consisting of flavonoids, alkaloids, terpenoids and phenolic compounds, the plant has impressive pharmacological effects such as wound healing, anti-inflammatory, antioxidant, antimicrobial and hepatoprotective properties. Although T. procumbens extracts have therapeutic potential, its clinical utility has been hampered by low bioavailability, instability and lack of skin penetration when delivered using standard dosage administration routes. There is a new category of elastic vesicular drug delivery systems called inavasomes that have come up as promising vehicles of improving transdermal delivery of phytochemicals. These ultra deformable vesicles that contain phospholipids, ethanol and terpenes or essential oils as penetration enhancers have better skin permeation, better drug deposition and better therapeutic efficacy than the traditional liposomes and niosomes. This thorough review is a critical analysis of the present state of knowledge on the preparation, characterization and pharmacological assessment of invasomal formulations of T. procumbens extracts. The review will include discussions on phytochemical constituents of T. procumbens, different preparation methods of invasomes, more sophisticated characterization, as well as pharmacological analysis of these new formulations. Moreover, the presented review will point out the gaps in the current research and suggest future avenues of the formation of clinically viable invasomal drug delivery systems in T. procumbens with a particular focus on the work of Indian researchers and comparative international views.


Cite this article:
Suman Kumar Rathore, Mohammad Akhtar Rasool, Mohammad Ayazuddin Farooqui, Yogesh Pounikar. Preparation, Characterization and Pharmacological Evaluation of Inavasome of Vesicular System of Tridax procumbens: A Comprehensive Review. Research Journal of Pharmaceutical Dosage Forms and Technology.2026; 18(3):217-6. doi: 10.52711/0975-4377.2026.00032

Cite(Electronic):
Suman Kumar Rathore, Mohammad Akhtar Rasool, Mohammad Ayazuddin Farooqui, Yogesh Pounikar. Preparation, Characterization and Pharmacological Evaluation of Inavasome of Vesicular System of Tridax procumbens: A Comprehensive Review. Research Journal of Pharmaceutical Dosage Forms and Technology.2026; 18(3):217-6. doi: 10.52711/0975-4377.2026.00032   Available on: https://rjpdft.com/AbstractView.aspx?PID=2026-18-3-7


8. REFERENCES:
1.    Pumila Singh, Divya Sharma, Varsha Singh, Sheila Kumari, Arjun Singh, Hema Jain. Management of non-hospitalized patients with Acute SARS-CoV-2 (COVID-19) viral infection in among human adult population. Asian Journal of Management. 2023; 14(4): 227-2.
2.    Poonam Sheoran, Sulakshana Chand, Sukhwinder Kaur. Comparison of Infra Red-Light Therapy vs. Sitz Bath on episiotomy in terms of wound healing among postnatal mothers. Asian J. Nur. Edu. and Research.  2014; 4(1): 70-75.
3.    R. Ramasubramaniaraja. Pharmacognostical Phytochemical Including GC-MS Investigation of Ethanolic Leaf Extracts of Abutilon indicum (Linn). Asian J. Pharm. Ana. 2011; 1(4): 88-92.
4.    Preeti Tiwari. Phenolics and Flavonoids and Antioxidant Potential of Balarishta Prepared by Traditional and Modern Methods. Asian J. Pharm. Ana. 2014; 4(1): 5-10.
5.    Alex Nemtsov, Pavel Kirshkov. The Study of Precision of ISO 3632-2 Method for Analysis of Herbal Medicines. Asian J. Pharm. Ana. 2020; 10(3):125-128.
6.    Muthusamy Senthil Kumar, Srinivasan Balachandran, Shibani Chaudhury. Influence of Incubation Temperatures on Total Phenolic, Flavonoids Content and Free Radical Scavenging Activity of Callus from Heliotropium indicum L. Asian J. Pharm. Res. 2012; 2(4): 148-152.
7.    M. Ezhumalai, G. Hemalatha, J.P. Poornima, K.V. Pugalendi. Inhibition of Lactobacillus growth by amino acids and phytochemicals in the fermentation of curd by disc diffusion method. Asian J. Pharm. Res. 2013; 3(4): 189-193.
8.    Yogita R. Indalkar, Nayana V. Pimpodkar, Anita S. Godase, Puja S. Gaikwad. A Compressive Review on the Study of Nanotechnology for Herbal Drugs. Asian J. Pharm. Res. 2015; 5(4): 203-207
9.    Deepa Amminbavi, N Prasanna Lakshmi. Assessment of In vitro wound healing potential of Hibiscus leaf extract Emulgel. Asian J. Pharm. Res. 2020; 10(2): 67-72.
10.    Popat S. Kumbhar, Tejaswini P. Jadhav, Swapnil S. Chopade, Tejas T. Gavade, Rushikesh C. Sorate, Tejaswini U. Shinde, Pratik P. Maske, John I. Disouza, Arehalli S. Manjappa. Microneedles: An Advanced approach for Transdermal Delivery of Biologics. Asian J. Pharm. Res. 2021; 11(1): 46-54.
11.    Ahmed, S. S., Prakash, K. C., Tabassum, S. and Kumar, K. P. Pharmacognostical and pharmacological review on Tridax procumbens Linn. Research Journal of Pharmacology and Pharmacodynamics.  2019; 11(1): 25-32. https://doi.10.5958/2321-5836.2019.00003.X 
12.    Amoabediny, G., Haghiralsadat, F., Naderinezhad, S., Zandieh-Doulabi, B., Forouzanfar, T. and Helder, M. N. Overview of preparation methods of polymeric and lipid-based (niosome, solid lipid, liposome) nanoparticles: A comprehensive review. International Journal of Polymeric Materials and Polymeric Biomaterials. 2018; 67(6): 383-400. https://doi.org/10.1080/00914037.2017.1332623
13.    Ascenso, A., Raposo, S., Batista, C., Cardoso, P., Mendes, T. and Simoes, S. Development, characterization and skin delivery studies of related ultradeformable vesicles: Transfersomes, ethosomes and transethosomes. International Journal of Nanomedicine. 2015; 10: 5837-5851. https://doi.org/10.2147/IJN.S86186
14.    Babaie, S., Del Bakhshayesh, A. R., Ha, J. W., Hamishehkar, H. and Kim, K. H. Inavasome: A novel nanocarrier for transdermal drug delivery. Nanomaterials. 2020; 10(2): 341. https://doi.org/10.3390/nano10020341
15.    Bartelds, R., Nematollahi, M. H., Pols, T., Stuart, M. C. A., Pardakhty, A. and Vries, R. J. Niosomes, an alternative for liposomal delivery. PLoS One. 2018; 13(9): e0194179. https://doi.org/10.1371/journal.pone.0194179
16.    Bhagat, V. C. and Kondawar, M. S. A comprehensive review on phytochemistry and pharmacological use of Tridax procumbens Linn. Journal of Pharmacognosy and Phytochemistry. 2019; 8(3): 1-6.
17.    Burgos-Pino, J., Gual-Orozco, B., Vera-Ku, M., Loría-Cervera, E. N., Guillermo-Cordero, L., Martínez-Vega, P. P., Torres-Tapia, L. W., Castro-Valencia, K., Peraza-Sánchez, S. R., and Gamboa-León, R. Acute oral toxicity in BALB/c mice of Tridax procumbens and Allium sativum extracts and (3S)-16,17-didehydrofalcarinol. Journal of Ethnopharmacology. 2023; 301: 115840. https://doi.org/10.1016/j.jep.2022.115840
18.    Chinnappan, B. A., Krishnaswamy, M., Bal, T., and Rajora, A. D. In vitro–in vivo wound healing efficacy of Tridax procumbens extract loaded carboxymethylcellulose film. International Journal of Biological Macromolecules. 2023; 253(Pt 1): 126695. https://doi.org/10.1016/j.ijbiomac.2023.126695
19.    Cui, H.-X., Zhang, L.S., Yan, H.G., Yuan, K., and Jin, S. Constituents of flavonoids from Tridax procumbens L. and antioxidant activity. Pharmacognosy Magazine. 2020; 16: 201. https://doi.org/10.4103/pm.pm_229_19
20.    Dattaray, D. Traditional uses and pharmacology of plant Tridax procumbens: A review. Systematic Reviews in Pharmacy. 2022; 13(7): 476–482. https://doi.org/10.31858/0975-8453.13.7.476-482
21.    Dewi, M. K., Chaerunisaa, A. Y., Muhaimin, M. and Joni, I. M. Improved activity of herbal medicines through nanotechnology. Nanomaterials.  2022; 12(22): 4073. https://doi.org/10.3390/nano12224073.

Recomonded Articles:

Author(s): Gayatri D. Patil, Kaveri P. Tambe, Sangita P. Shirsat, Paresh A. Patil

DOI: 10.5958/0975-4377.2021.00015.X         Access: Open Access Read More

Author(s): Swapnil T. Deshpande, P. S. Vishwe, Rohit D. Shah, Swati S. Korabu, Bhakti R. Chorghe, DG Baheti

DOI:         Access: Open Access Read More

Author(s): Dipti G. Phadtare, Amol R. Pawar, R.B. Saudagar, Govind K.Patil

DOI: 10.5958/0975-4377.2017.00002.7         Access: Open Access Read More

Author(s): Kritika Kanoujia, Chandraprabha Dewangan, Ayushi Masih, Dipti Sinha, Divya Oraon, Manisha Jaiswal, Monika Sahu, Ranjeeta Kumari, Sapna Pradhan, Ravi Suman, Rajkishan Dewangan, Roman Banjare, Pradeep Paikra, Mukesh Rawtiya, Mukta Agrawal, Ajazuddin, D. K. Tripathi, Amit Alexander

DOI: 10.5958/0975-4377.2018.00015.0         Access: Open Access Read More

Author(s): Prashant Gupta, Dipti H. Patel, Nilesh Dhameliya, Pratik Modh, Vishvesh Joshi

DOI: 10.52711/0975-4377.2023.00047         Access: Open Access Read More

Author(s): Bhaskar Kurangi, Sandesh Somnache, Nilesh Jangade

DOI:         Access: Open Access Read More

Author(s): Priti B. Savant, Shrikrushna A. Shinde, Jayamala S. Barge

DOI: 10.52711/0975-4377.2022.00042         Access: Open Access Read More

Author(s): Sayad Basha.K, Sheema Nafees. S, Nethravani. G, Thirumalesh Naik S.B

DOI: 10.5958/0975-4377.2016.00015.X         Access: Open Access Read More

Author(s): Saikumar Y., Saikishore V., Pavani K., Sairam D.T., Sindhura A.

DOI:         Access: Open Access Read More

Author(s): Chirag A. Patel, Priyal R. Patel, Dhrubo Jyoti Sen,Jayvadan K. Patel

DOI:         Access: Open Access Read More

Author(s): Patil Namrata D., Gondkar S.B., Saudagar R.B.

DOI: 10.5958/0975-4377.2016.00033.1         Access: Open Access Read More

Author(s): Amallia Rachmasari, Rafidha Aisyah Kartini, Gita Alviani, Indah Solihah

DOI: 10.5958/0975-4377.2019.00046.6         Access: Open Access Read More

Author(s): Varsha R. Sandhan, S.B. Gondkar, R. B. Saudagar

DOI:         Access: Open Access Read More

Author(s): Keshav Dhiman, Anshul Sharma, Anshul Sharma, Kamya Goyal, Vinay Pandit, M. S. Ashawat, Shammy Jindal

DOI: 10.52711/0975-4377.2022.00050         Access: Open Access Read More

Author(s): Rajkumar Prasad Yadav, F. R. Sheeba

DOI: 10.52711/0975-4377.2021.00023         Access: Open Access Read More

Author(s): Hardik B. Rana, Kajol Patel, Mansi Dholakia, Vaishali T. Thakkar, Mukesh C. Gohel, Tejal R. Gandhi

DOI: 10.5958/0975-4377.2017.00006.4         Access: Open Access Read More

Author(s): Sushant R. Jagtap, D.G Phadtare, R.B. Saudagar

DOI: 10.5958/0975-4377.2016.00021.5         Access: Open Access Read More

Author(s): Ashok Thulluru, K. Saravanakumar, Ch. S. Phani Kumar, Nawaz Mahammed, D. Sreeja, G. Bhuvanesh, N. Vamsi Chowdary, Nayeema Khowser Shaik

DOI: 10.5958/0975-4377.2019.00049.1         Access: Open Access Read More

Author(s): Shaikh Arbaz Ajaz, Quazi Majaz, Imran Kalam, Aminoddin Shaikh, Museb Shaikh, Pathan Ayyaj

DOI: 10.52711/0975-4377.2024.00034         Access: Open Access Read More

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0975-4377 


Recent Articles




Tags