Formulation Development and Evaluation of Orodispersible Tablet of Omeprazole by Using Co-Processed Superdisintegrant.

Sharad A. More; Shrinivas K. Mohite

Research Journal of Pharmaceutical Dosage Forms and Technology

ISSN

0975-4377 (Online)
0975-234X (Print)

Submit Article

Formulation Development and Evaluation of Orodispersible Tablet of Omeprazole by Using Co-Processed Superdisintegrant.

Author(s): Sharad A. More, Shrinivas K. Mohite

Email(s): sharadpharm@gmail.com

DOI: Not Available

Address: Sharad A. More, Shrinivas K. Mohite
Department of Quality Assurance, Rajarambapu College of Pharmacy, Kasegaon, Sangli, India.
*Corresponding Author

Published In: Volume - 4, Issue - 4, Year - 2012

View HTML

View PDF

ABSTRACT:
In the present study, novel co-processed superdisintegrants were developed by solvent evaporation method using crospovidone and crosscarmellose sodium in different ratios (1:1, 1:3 and 3:1) for use in the fast dissolving tablet formulations. The developed excipients were evaluated for angle of repose, Carr’s index and Hausner’s ratio in comparison with physical mixture of superdisintegrants. The angle of repose of the developed excipients was found to be <23o, Carr’s index in the range of 11-21% and Hausner’s ratio in the range of 1.13-1.6. ordispersible tablets of omeprazole were prepared using the above co-processed superdisintegrants and evaluated for pre-compression and post-compression parameters. Based on in vitro dispersion time (approximately 21sec), promising formulation CP1 was tested for in vitro drug release pattern in pH 6.8 Phosphate buffer, drug excipient interaction (IR spectroscopy). Among the designed formulations, the formulation (CP1) containing 6% w/w of co processed superdisintegrant (1:1 mixture of crospovidone and croscarmellose sodium) emerged as the overall best formulation based on drug release characteristics in pH 6.8 phosphate buffer compared to commercial conventional tablet formulation.

Keywords:

Cite this article:
Sharad A. More, Shrinivas K. Mohite. Formulation Development and Evaluation of Orodispersible Tablet of Omeprazole by Using Co-Processed Superdisintegrant.. Research J. Pharma. Dosage Forms and Tech. 2012; 4(4): 216-220.

Cite(Electronic):
Sharad A. More, Shrinivas K. Mohite. Formulation Development and Evaluation of Orodispersible Tablet of Omeprazole by Using Co-Processed Superdisintegrant.. Research J. Pharma. Dosage Forms and Tech. 2012; 4(4): 216-220. Available on: https://rjpdft.com/AbstractView.aspx?PID=2012-4-4-5

Recomonded Articles:

Isolation and evaluation of Basella alba linn. Leaf mucilage as release retardant in tablet formulation

Author(s): Yamunappa, Ravi Kumar, Pooja Shetty, Prathibha Suvarna, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00012.4 Access: Open Access Read More

Pharmaceutical Suspensions: Pharmacist has the Very Best Possible Formulation for the Job at Hand.

Author(s): Praneta Desale

DOI: Access: Open Access Read More

Formulation and Evaluation of Fast Dissolving Tablets of Trimetazidine Dihydrochloride Using Natural and Synthetic Superdisintegrants

Author(s): Simila Madathil, RaviKumar, Anju Govind, Mercy Mathew, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00013.6 Access: Open Access Read More

Formulation and Evaluation of Fast Dissolving Tablets containing Clopidogrel bisulfate using holy basil seeds as a natural superdisintegrant

Author(s): Omprasad Nayakal, Prajakta Patil, Mangesh Bhutkar, Dheeraj Randive, Somnath Bhinge

DOI: 10.5958/0975-4377.2018.00032.0 Access: Open Access Read More

Evaluation of Seed Mucilage of Hibiscus Sabdariffa Linn as Tablet Binder

Author(s): Ch. Anupama, P. Padmakumari, K. Abbulu, Arti Mohan, A. Ppratyusha

DOI: Access: Open Access Read More

Controlled Porosity Osmotic Pump Tablets of Zidovudine and Lamivudine Combination: Optimization and Characterization

Author(s): Chinmaya Keshari Sahoo, Surepalli Ram Mohan Rao, Muvvala Sudhakar

DOI: 10.5958/0975-4377.2017.00020.9 Access: Open Access Read More

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

RNI: Not Available
DOI: 10.5958/0975-4377