Author(s): Vijaya Kumar V., Raghuram N., K. Hari Krishna, K. Rajyalakshmi, Y. Indira Muzib

Email(s): rajimanohar3529@gmail.com

DOI: Not Available

Address: Vijaya Kumar V.2, Raghuram N.2, K. Hari Krishna2, K. Rajyalakshmi2* and Y. Indira Muzib1.
1Associate Professor, Sri Padamavati Mahila University, Tirupati. 2Bapatla college of Pharmacy, Bapatla.
*Corresponding Author:

Published In:   Volume - 3,      Issue - 4,     Year - 2011


ABSTRACT:
Colon specific drug delivery has gained a much importance for the delivery of drugs to treat the both local and systemic diseases. Local diseases include Chron’s disease, ulcerative colitis, and colorectal cancer. Number of other serious disorders like nocturnal asthma, arthritis and angina can also be cured by these techniques. Colonic delivery is a good candidature for delivery of proteins peptides and vaccines where the enzymatic degradation and the hydrolysis of proteins can be minimized and increases the systemic bioavailability. A drug should be protected from the absorption and the upper GI environment to achieve the successful colonic drug delivery. The colon specific delivery of drugs to the target receptor sites has the advantage to reduce the side effects and improves the therapeutic response. Colon specific drug delivery are being developed by taking advantage of the luminal PH conditions and the presence of microbial enzymes such as azoreductase, pectinase, dextranase…etc. This review mainly reveals on the various concepts and approaches include Prodrug, PH and time dependent systems and microbially triggered systems used in the development of colon specific drug delivery. This also focuses on the novel approaches namely Pressure controlled colonic delivery, osmotic controlled drug delivery and CODESTM. Invitro and in vivo evaluation parameters has been discussed here.


Cite this article:
Vijaya Kumar V., Raghuram N., K. Hari Krishna, K. Rajyalakshmi, Y. Indira Muzib. A review on colonic drug delivery System. Research J. Pharma. Dosage Forms and Tech. 2011; 3(4) 122-129.


Recomonded Articles:

Author(s): Dipti G. Phadtare, Amol R. Pawar, R.B. Saudagar, Govind K.Patil

DOI: 10.5958/0975-4377.2017.00002.7         Access: Open Access Read More

Author(s): Swapnil T. Deshpande, P. S. Vishwe, Rohit D. Shah, Swati S. Korabu, Bhakti R. Chorghe, DG Baheti

DOI:         Access: Open Access Read More

Author(s): Patil Namrata D., Gondkar S.B., Saudagar R.B.

DOI: 10.5958/0975-4377.2016.00033.1         Access: Open Access Read More

Author(s): Chirag A. Patel, Priyal R. Patel, Dhrubo Jyoti Sen,Jayvadan K. Patel

DOI:         Access: Open Access Read More

Author(s): Hardik B. Rana, Kajol Patel, Mansi Dholakia, Vaishali T. Thakkar, Mukesh C. Gohel, Tejal R. Gandhi

DOI: 10.5958/0975-4377.2017.00006.4         Access: Open Access Read More

Author(s): Masheer Ahmed Khan

DOI:         Access: Open Access Read More

Author(s): Nakkala Balaji , V. Sai Kishore , Kasani Hari Krishna Gouda

DOI:         Access: Open Access Read More

Author(s): Kritika Kanoujia, Chandraprabha Dewangan, Ayushi Masih, Dipti Sinha, Divya Oraon, Manisha Jaiswal, Monika Sahu, Ranjeeta Kumari, Sapna Pradhan, Ravi Suman, Rajkishan Dewangan, Roman Banjare, Pradeep Paikra, Mukesh Rawtiya, Mukta Agrawal, Ajazuddin, D. K. Tripathi, Amit Alexander

DOI: 10.5958/0975-4377.2018.00015.0         Access: Open Access Read More

Author(s): Shoaib Ahmad

DOI: 10.5958/0975-4377.2016.00041.0         Access: Open Access Read More

Author(s): Swati Rawat, Shradha Sangali, Akhilesh Gupta

DOI: 10.5958/0975-4377.2018.00001.0         Access: Open Access Read More

Author(s): V. Saikishore, G. Srikanth, Ch. Pooja, Y. Mrudula, R. Pavani, Ch. Jyosthna , C. Mayuren

DOI:         Access: Open Access Read More

Author(s): Suresh A. Marnoor

DOI:         Access: Open Access Read More

Author(s): Patil GB, Deshmukh PK, Belgamwar VS

DOI:         Access: Open Access Read More

Author(s): Amrita Thakur, Nisha Nair, Mukta Agrawal, Yashi Thakur, Juhi Thakur,TemanNirmalkar,VedPrakashVerma,Vibhash Gupta,Vivek Singh Yadav,KalpanaMahilange, PoojaMahant, PritamYadav, Deepak Patel, Dinesh Khamari, JyotsanaMeshram, RakeshSahu, TarunGhatode, D. K. Tripathi, Ajazuddin, Amit Alexander

DOI: 10.5958/0975-4377.2018.00018.6         Access: Open Access Read More

Author(s): Desale Kishor B. Darekar A.B., Saudagar R.B.

DOI: 10.5958/0975-4377.2016.00029.X         Access: Open Access Read More

Author(s): Selvaraju K., Vengadesh Prabhu K., Karthick K., Padma Preetha J., Arul Kumaran K.S.G.

DOI:         Access: Open Access Read More

Author(s): Patel Chirag J., Asija Sangeeta, Patel Pinkesh, Mangukia Dhruv, Satyanand Tyagi

DOI:         Access: Open Access Read More

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0975-4377 


Recent Articles




Tags