Author(s):
Wajid Ahmad, Rihan Jawed, Yashdeep Thakur, Reena Thakur
Email(s):
wajidahmad806@gmail.com
DOI:
10.52711/0975-4377.2023.00026
Address:
Wajid Ahmad1*, Rihan Jawed1, Yashdeep Thakur2, Reena Thakur2
1Department of Pharmaceutical Science, Institute of Pharmacy, Ankara, Turkey.
2Department of Pharmacology, School of Pharmaceutical Research, Turkey.
*Corresponding Author
Published In:
Volume - 15,
Issue - 3,
Year - 2023
ABSTRACT:
The aim of the present study was to evaluate the effects of Tridax procumbens extract on calcium oxalate and calcium phosphate by in vitro methods. The leaves of Tridax procumbens were sequentially extracted by using hot maceration method, with solvent such as ethanol, water and hydroalcoholic solution in various concentrations. The obtained extract was subjected for phytochemical screening and the test for alkaloid, flavonoid, saponin, phenol, triterpenoid saponin. For the in vitro study, experimentally calcium phosphate and calcium oxalate stones were prepared and compared with standard drug. Cystone used as a standard drug. Tridax procumbens is rich in phytochemicals such as alkaloids, saponin, glycoside, kamferol, and flavonoids and has a substantial capacity to dissolve calcium phosphate and calcium oxalate. These flavonoids inhibit calcium Phosphate and calcium oxalate deposits from forming in the renal tubules. The leaf extract contains anti-urolithiasis therapy and preventative capabilities and lowers the size of stones. In addition to diuretic and antiurolithic, antidiabetic, anticancer, anti-ulcer, anti-microbial, and wound healing activities, Tridax procumbens flower extract includes phenolic chemicals, tannin, and titerpenes. The main goal of the study is to find out how the Tridax procumbens herb, especially its leaves, can prevent and treat health problems like renal stones, which are becoming more common in younger people because they don't exercise and eat poorly. The ability of the extract to get small particles out of the kidney and out of the urinary tract reduces the chance that they will get stuck in the urinary tract and form stones.
Cite this article:
Wajid Ahmad, Rihan Jawed, Yashdeep Thakur, Reena Thakur. In-vitro Assessment of Antiurolithiatic activity of Tridax procumbens Flower Extracts. Research Journal of Pharmaceutical Dosage Forms and Technology. .2023; 15(3):157-2. doi: 10.52711/0975-4377.2023.00026
Cite(Electronic):
Wajid Ahmad, Rihan Jawed, Yashdeep Thakur, Reena Thakur. In-vitro Assessment of Antiurolithiatic activity of Tridax procumbens Flower Extracts. Research Journal of Pharmaceutical Dosage Forms and Technology. .2023; 15(3):157-2. doi: 10.52711/0975-4377.2023.00026 Available on: https://rjpdft.com/AbstractView.aspx?PID=2023-15-3-2
REFERENCES:
1. Malviya V, Ladhake V, Gajbiye K, Satao J, Tawar M. Design and Characterization of Phase Transition System of Zolmitriptan Hydrochloride for Nasal Drug Delivery System. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020 May 31; 13(3):4942-51.
2. Malviya VR, Pande SD, Bobade NN. Preparation and Evaluation of Sustained Release Beads of Zolmitriptan Hydrochloride. Research Journal of Pharmacy and Technology. 2019 Dec 30; 12(12):5972-6.
3. Malviya VR, Pande SD. Road CKN. Preparation ad Evaluation of Zolmitriptan Hydrochloride Lozenge. J Pharma Res. 2019; 8(8):624-9.
4. Malviya VR, Tawar MG. Preparation and Evaluation of Oral Dispersible Strips of Teneligliptin Hydrobromide for Treatment of Diabetes Mellitus. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020 Jan 31; 13(1):4745-52.
5. Fürer K, Simões-Wüst AP, von Mandach U, Hamburger M, Potterat O. Tridax procumbens and related species used in anthroposophic medicine: constituents, pharmacological activities, and clinical efficacy. Planta Medica. 2016 Jul; 82(11/12):930-41.
6. Malviya V, Manekar S. Design, Development and Evaluation of Aceclofenac and Curcumin Agglomerates by Crystallo Co-Agglomeration Technique. Research Journal of Pharmacy and Technology. 2021 Mar 1; 14(3):1535-41.
7. Burange PJ, Tawar MG, Bairagi RA, Malviya VR, Sahu VK, Shewatkar SN, Sawarkar RA, Mamurkar RR. Synthesis of silver nanoparticles by using Aloe vera and Thuja orientalis leaves extract and their biological activity: a comprehensive review. Bulletin of the National Research Centre. 2021 Dec; 45(1):1-3.
8. Malviya V. Preparation and Evaluation of Emulsomes as a Drug Delivery System for Bifonazole. Indian Journal of Pharmaceutical Education and Research. 2021 Jan 1; 55(1):86-94.
9. Malviya V, Pande S. Development and Evaluation of Fast dissolving Film of Fluoxetine hydrochloride. Research Journal of Pharmacy and Technology. 2021 Oct 31; 14(10):5345-0.
10. Malviya V. Design and Characterization of Thermosensitive Mucoadhesive Nasal Gel for Meclizine Hydrochloride. International Journal of Pharmaceutical Sciences and Nanotechnology. 2022 Feb 28; 15(1):5782-93.
11. Malviya V, Burange P, Thakur Y, Tawar M. Enhancement of Solubility and Dissolution Rate of Atazanavir Sulfate by Nanocrystallization. Indian Journal of Pharmaceutical Education and Research. 2021 Jul 1; 55(3):S672-80.
12. Malviya, Vedanshu, Mukund Tawar, Prashant Burange, and Rahul Jodh. A Brief Review on Resveratrol. 2022: 157-162.
13. Lin K, Wu C, Chang J. Advances in synthesis of calcium phosphate crystals with controlled size and shape. Acta Biomaterialia. 2014 Oct 1; 10(10):4071-102.
14. Shangraw RF. Compressed tablets by direct compression. Pharmaceutical Dosage forms: Tablets. 1989 Jun 5; 1:195-246.
15. Bansode P, Pawar P, Babar M. Invitro Urolithiatic Activity Of Tridax procumbens Against Experimentally Designed Calcium Oxalate And Calcium Phosphate Stones.
16. Yadav M, Gulkari VD, Wanjari MM. Tridax procumbens leaf extracts prevent formation of renal calculi in lithiatic rats. Ancient Science of Life. 2016 Oct; 36(2):90.
17. Nagarajan Y, Boopathi R, Yahoob SA, Venkatraman A. In Vitro Evaluation of Anti Urolithiatic Activity of Tridax procumbens Lam. In Vitro. 2019 Aug; 5(8):97-102.
18. Malviya V, Tawar M, Burange P, Bairagi R. Preparation and Characterization of Gastroreten-tive Sustained Release In-situ Gel of Lafutidine. International Journal of Pharmaceutical Sciences and Nanotechnology (IJPSN). 2022 Dec 12; 15(6):6216-28.
19. Jagtap PN, Vyapari BR, Nimbalkar YH, Kale SV, Nigade GB. Evaluation of antiurolithiatic activity of polyherbal formulation (Lithout Tablets) by in-vitro inhibition of calcium oxalate crystallization. Research Journal of Pharmacy and Technology. 2019 Nov 1; 12(11):5477-8.
20. Malviya V, Arya A, Burange P, Gajbhiye K, Rathod G, Tawar M. To Evaluate the Cardioprotective effect of Hydroalcoholic Extract of Matricaria chamomilla Linn in Isoproterenol Induced Myocardial Infarction in Wistar Rats. Research Journal of Pharmacy and Technology. 2022 Sep 28; 15(9):3887-92.
21. Malviya V, Thakur Y, Gudadhe SS, Tawar M. Formulation and evaluation of natural gum based fast dissolving tablet of Meclizine hydrochloride by using 3 factorial design 2. Asian Journal of Pharmacy and Pharmacology. 2020; 6(2):94-100.
22. Kamakshi UN, Rao BG, Rao BV. Comparison of in vitro antiurolithiatic activity of Aerva lanata, Sphaeranthus indicus, Merremia emarginata. Research Journal of Pharmacy and Technology. 2017; 10(6):1653-6.
23. Kalita S, Kumar G, Karthik L, Rao KV. A Review on Medicinal Properties of Lantana camara Linn. Research Journal of Pharmacy and Technology. 2012; 5(6):711-5.
24. Kayalvizhi D, Sivakumar V, Jayanthi M. Phytochemical screening and antinephrolithiasis activity of ethanol extract of Aerva lanata on ethylene glycol induced renal stone in rats. Research Journal of Pharmacy and Technology. 2015 Nov 1; 8(11):1481.
25. Dhimmar N, Patel NM, Gajera V, Lambole V. Pharmacological activities of Moringa oleifera: an overview. Res J Pharm Tech. 2015 Apr 28; 10:476-80.