Bicalutamide Tablets by Spray Dried Microspheres: An Approach to Enhance Solubility

Rutuja R. Shah; Abhijeet Jadhav; Rohan R. Vakhariya

doi:10.5958/0975-4377.2017.00027.1

Research Journal of Pharmaceutical Dosage Forms and Technology

ISSN

0975-4377 (Online)
0975-234X (Print)

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Bicalutamide Tablets by Spray Dried Microspheres: An Approach to Enhance Solubility

Author(s): Rutuja R. Shah, Abhijeet Jadhav, Rohan R. Vakhariya

Email(s): rohanwakhariya@gmail.com

DOI: 10.5958/0975-4377.2017.00027.1

Address: Rutuja R. Shah*, Abhijeet Jadhav, Rohan R. Vakhariya
Rajarambapu College of Pharmacy, Kasegaon, Tal. Walwa, Dist. Sangli, Maharashtra, India.
*Corresponding Author

Published In: Volume - 9, Issue - 4, Year - 2017

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ABSTRACT:
The aim of the present study was to enhance the dissolution rate of poorly water soluble drug, Bicalutamide. Bicalutamide is an antiandrogen agent used in the treatment of prostate cancer. To improve the dissolution rate of the drug, hydrophilic carriers like povidone K30 was and methanol was used for preparing microspheres. Microspheres of Bicalutamide were prepared by spray drying technique by using povidone K 30 at different concentrations. The microspheres were evaluated for drug release profile. The compatibility was studied by Fourier Transforms Infrared spectroscopy (FTIR). Prepared Microspheres were subjected to various physicochemical evaluations and in-vitro dissolution profile. The effects of different concentrations of polymer on Solubility enhancement were studied. The microspheres were compressed into tablets, and different tableting parameters were investigated. The dissolution profile of the tablets was also evaluated and compared with the marketed product. From the dissolution profile, it was observed that the carrier ratio of 3:1 of magnesium aluminum silicate to povidone K 30 exhibited higher dissolution rate than the other formulations.

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Cite this article:
Rutuja R. Shah, Abhijeet Jadhav, Rohan R. Vakhariya. Bicalutamide Tablets by Spray Dried Microspheres: An Approach to Enhance Solubility. Res. J. Pharm. Dosage Form. & Tech. 2017; 9(4): 168-172. doi: 10.5958/0975-4377.2017.00027.1

Cite(Electronic):
Rutuja R. Shah, Abhijeet Jadhav, Rohan R. Vakhariya. Bicalutamide Tablets by Spray Dried Microspheres: An Approach to Enhance Solubility. Res. J. Pharm. Dosage Form. & Tech. 2017; 9(4): 168-172. doi: 10.5958/0975-4377.2017.00027.1 Available on: https://rjpdft.com/AbstractView.aspx?PID=2017-9-4-5

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DOI: 10.5958/0975-4377