Research Journal of Pharmaceutical Dosage Forms and Technology

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0975-4377 (Online)
0975-234X (Print)


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Molecular Aspects of BBB

Author(s): K. Venkata Ramana Reddy, Venkateshwara Reddy, Poonam Chandra Loya

Email(s): srikanth.papa@gmail.com

DOI: Not Available

Address: K. Venkata Ramana Reddy1*, Dr. Venkateshwara Reddy2, Poonam Chandra Loya1
1Associate Professor, Dept. of Pharmaceutics, Sree Dattha College of Pharmacy, R.R. Dt., Andhra Pradesh. India
2Associate Professor, Dept. of Pharmaceutics, St. Pauls College of Pharmacy, R.R., Dt. A.P. India
*Corresponding Author

Published In:   Volume - 6,      Issue - 2,     Year - 2014

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ABSTRACT:
The function of the BBB is dynamically regulated by various cells present at the level of the BBB. This realization implies better understanding of the relationship of at the BBB to drug structure and physicochemical properties. The physical barrier naming BBB is characterized by tight junctions between endothelial cells, by the absence of fenestrations and low occurrence of pinocytic activity 1.Penetration of chemicals to the BBB occurs using a combination of intra and intercellular passages. The main factors that limit the penetration of lipophilic membranes by any molecule are its molecular weight and its ability to form hydrogen bonds and so bind to circulating plasma proteins. Tight junctions regulate the intracellular passage of molecules according to their physico-chemical properties (e.g. lipophilicity, ionization and polarity), where inter cellular penetration is regulated by influx and efflux transporters, endocytosis and passive diffusion.


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Cite this article:
K. Venkata Ramana Reddy, Venkateshwara Reddy, Poonam Chandra Loya. Molecular Aspects of BBB. Res. J. Pharm. Dosage Form. and Tech. 6(2):April- June 2014; Page 105-109.

Cite(Electronic):
K. Venkata Ramana Reddy, Venkateshwara Reddy, Poonam Chandra Loya. Molecular Aspects of BBB. Res. J. Pharm. Dosage Form. and Tech. 6(2):April- June 2014; Page 105-109.   Available on: https://rjpdft.com/AbstractView.aspx?PID=2014-6-2-7


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DOI: 10.5958/0975-4377 

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Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. The aim of RJPDFT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPDFT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical Chemistry, Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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