Author(s): K. Venkata Ramana Reddy, Venkateshwara Reddy, Poonam Chandra Loya

Email(s): srikanth.papa@gmail.com

DOI: Not Available

Address: K. Venkata Ramana Reddy1*, Dr. Venkateshwara Reddy2, Poonam Chandra Loya1
1Associate Professor, Dept. of Pharmaceutics, Sree Dattha College of Pharmacy, R.R. Dt., Andhra Pradesh. India
2Associate Professor, Dept. of Pharmaceutics, St. Pauls College of Pharmacy, R.R., Dt. A.P. India
*Corresponding Author

Published In:   Volume - 6,      Issue - 2,     Year - 2014


ABSTRACT:
The function of the BBB is dynamically regulated by various cells present at the level of the BBB. This realization implies better understanding of the relationship of at the BBB to drug structure and physicochemical properties. The physical barrier naming BBB is characterized by tight junctions between endothelial cells, by the absence of fenestrations and low occurrence of pinocytic activity 1.Penetration of chemicals to the BBB occurs using a combination of intra and intercellular passages. The main factors that limit the penetration of lipophilic membranes by any molecule are its molecular weight and its ability to form hydrogen bonds and so bind to circulating plasma proteins. Tight junctions regulate the intracellular passage of molecules according to their physico-chemical properties (e.g. lipophilicity, ionization and polarity), where inter cellular penetration is regulated by influx and efflux transporters, endocytosis and passive diffusion.


Cite this article:
K. Venkata Ramana Reddy, Venkateshwara Reddy, Poonam Chandra Loya. Molecular Aspects of BBB. Res. J. Pharm. Dosage Form. and Tech. 6(2):April- June 2014; Page 105-109.


Recomonded Articles:

Author(s): Yamunappa, Ravi Kumar, Pooja Shetty, Prathibha Suvarna, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00012.4         Access: Open Access Read More

Author(s): Swati Talokar, Rohan R Vakhariya, A.R Dhole

DOI: 10.5958/0975-4377.2017.00005.2         Access: Open Access Read More

Author(s): Rakesh P. Patel, Grishma Patel, Hitesh Patel , Ashok Baria

DOI:         Access: Open Access Read More

Author(s): Sushant R. Jagtap, D.G Phadtare, R.B. Saudagar

DOI: 10.5958/0975-4377.2016.00021.5         Access: Open Access Read More

Author(s): Praveen Kumar Uppala, K. Atchuta Kumar, Murali Krishna, U. Upendra Rao

DOI: 10.5958/0975-4377.2016.00039.2         Access: Open Access Read More

Author(s): Yamunappa, Ravi Kumar, Pooja Shetty, Prathibha Suvarna, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00014.8         Access: Open Access Read More

Author(s): Shilpa N. Shrotriya, Kishore N. Gujar, Bhakti R. Chorghe

DOI:         Access: Open Access Read More

Author(s): Ashok A Hajare, Mahesh N Mali, Arun S Dange, Sushil M Sarvagod, Shweta V Patwardhan ,Sachin T Kurane

DOI:         Access: Open Access Read More

Author(s): B. Saraswathi, R. Jagadeesh Reddy, P. Swathi, G. Manasa

DOI: 10.5958/0975-4377.2017.00025.8         Access: Open Access Read More

Author(s): Ch. Anupama, P. Padmakumari, K. Abbulu, Arti Mohan, A. Ppratyusha

DOI:         Access: Open Access Read More

Author(s): Alok Ranjan, Aishwarya Sahu, Akansha Yadav, Alka Payasi, Akash Jaiswal, Akshay Kumar, Akash Sahu, Ashwani Jangde, Chandrashekhar Nayak, Dev Kumar, Harshita Yarda, Mitali Sahu, Nokesh Sahu, Rajesh Patel, Nisha Nair, Mukta Agrawal, Ajazuddin, D. K. Tripathi, Amit Alexander

DOI: 10.5958/0975-4377.2018.00014.9         Access: Open Access Read More

Author(s): Viswanadham Manasa, K.Vanitha, M. Venkataswamy, P. Prabhakar, Alluri Ramesh

DOI: 10.5958/0975-4377.2016.00002.1         Access: Open Access Read More

Author(s): Shashikant Chandrakar , Swarnalata Saraf

DOI:         Access: Open Access Read More

Author(s): Gannu Praveen Kumar, S. Kiran Kumar

DOI:         Access: Open Access Read More

Author(s): Umesh Kumar, Khuman Lal, Navneet Patel, Lekhraj, Jai Prakash, Omkar, Jai Prakash, Rakesh Gurjar, Achyutanand Gupta, Chandra Prakash, Mukta Agrawal, Ajazuddin, D. K. Tripathi, Amit Alexander

DOI: 10.5958/0975-4377.2018.00016.2         Access: Open Access Read More

Author(s): Amit K. Jain, Rajput Rammulrajsinh, Pradeep Agrawal, Kinal patel

DOI:         Access: Open Access Read More

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0975-4377 


Recent Articles




Tags