Author(s): Nikunj Patel, Ashok Kumar P, Basavaraj, Tom Damien, Someshwara Rao B, Suresh V Kulkarni

Email(s): ashokkumarscp@yahoo.com ,

DOI: Not Available

Address: Nikunj Patel, Ashok Kumar P*, Basavaraj, Tom Damien, Someshwara Rao B and Suresh V Kulkarni
Department of Pharmaceutics, Sree Siddaganga College of Pharmacy, B.H. Road, Tumkur-572102, Karnataka, India.
*Corresponding Author

Published In:   Volume - 2,      Issue - 2,     Year - 2010


ABSTRACT:
In the present investigation an attempt was made to formulate the oral controlled release metformin hydrochloride matrix tablets by using Guar gum as rate controlling polymer and to evaluate drug release parameters as per various release kinetic models. The tablets were prepared by wet granulation method. Granules were prepared and evaluated for loose bulk density, tapped density, compressibility index and angle of repose, shows satisfactory results. All the granules were lubricated and compressed using 12.8 mm flat faced punches. Compressed tablets were evaluated for uniformity of weight, content of active ingredient, friability, hardness, in vitro release studies and swelling index. All the formulations showed compliance with Pharmacopoeial standards. The in vitro dissolution study was carried out for 12 hours using paddle (USP type II) method in phosphate buffer (pH 6.8) as dissolution media. The prepared matrix tablets were shown 99.92%, 97.41%, 94.95%, 89.29%, 86.41% and 84.72% release over a period of 12 hours. Formulations F-1 and F-2 failed to sustain release beyond 9 hours and 11 hours, respectively. Among all the formulations, F-5 showed the controlled release of drug for 12 hours with 86.41% release and the release profile was close to the marketed sample of metformin hydrochloride (M-SR). Selected formulation (F-5) was subjected to stability studies for 3 months, which showed stability with respect to release pattern. The drug release follows first order kinetics and the mechanism was found to be diffusion coupled with erosion.


Cite this article:
Nikunj Patel, Ashok Kumar P, Basavaraj, Tom Damien, Someshwara Rao B , Suresh V Kulkarni. Use of Hydrophilic Natural Guar Gum in Formulation of Controlled-Release Matrix Tablets of Metformin Hydrochloride and Its Comparison with Marketed Product. Research J. Pharma. Dosage Forms and Tech. 2010; 2(2):193-197.


Recomonded Articles:

Author(s): Yamunappa, Ravi Kumar, Pooja Shetty, Prathibha Suvarna, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00012.4         Access: Open Access Read More

Author(s): Debjit Bhowmik, Amrendra Singh , Praveen Khirwadkar, Nishi Shukla, Vikas Kumar Chaudhari

DOI: 10.5958/0975-4377.2016.00027.6         Access: Open Access Read More

Author(s): Masheer Ahmed Khan

DOI:         Access: Open Access Read More

Author(s): Sawant VA, Jayprabha P, Shende VS, Borkar SN, Wakale VS, Deore SR, Dame GY, Barve AO, Chatap VK

DOI:         Access: Open Access Read More

Author(s): Praveen Kumar Uppala, K. Atchuta Kumar, Murali Krishna, U. Upendra Rao

DOI: 10.5958/0975-4377.2016.00039.2         Access: Open Access Read More

Author(s): Yamunappa, Ravi Kumar, Pooja Shetty, Prathibha Suvarna, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00014.8         Access: Open Access Read More

Author(s): Debjit Bhowmik, Rishab Bhanot, K.P. Sampath Kumar

DOI: 10.5958/0975-4377.2018.00036.8         Access: Closed Access Read More

Author(s): V. Saikishore, G. Srikanth, Ch. Pooja, Y. Mrudula, R. Pavani, Ch. Jyosthna , C. Mayuren

DOI:         Access: Open Access Read More

Author(s): AL. Akilandeshwari , K. Elango, S. Daisy Chellakumari, S. Kishore Kumar

DOI:         Access: Open Access Read More

Author(s): Swati Rawat, Shradha Sangali, Akhilesh Gupta

DOI: 10.5958/0975-4377.2018.00001.0         Access: Open Access Read More

Author(s): Manish P Patel, MM Patel, KN Patel, DR Patel,UL Patel

DOI:         Access: Open Access Read More

Author(s): Soham Shukla, Vikram Pandya, Praful Bhardia, Nitin Jonwal, Shashank Mishra, Deepak Bhatt, Deependra Jain

DOI:         Access: Open Access Read More

Author(s): Ch. Anupama, P. Padmakumari, K. Abbulu, Arti Mohan, A. Ppratyusha

DOI:         Access: Open Access Read More

Author(s): Alok Ranjan, Aishwarya Sahu, Akansha Yadav, Alka Payasi, Akash Jaiswal, Akshay Kumar, Akash Sahu, Ashwani Jangde, Chandrashekhar Nayak, Dev Kumar, Harshita Yarda, Mitali Sahu, Nokesh Sahu, Rajesh Patel, Nisha Nair, Mukta Agrawal, Ajazuddin, D. K. Tripathi, Amit Alexander

DOI: 10.5958/0975-4377.2018.00014.9         Access: Open Access Read More

Author(s): Sachin N. Kothawade, Ashwini Ishware, Priyanka Darekar, Amit S. Lunkad

DOI:         Access: Open Access Read More

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0975-4377 


Recent Articles




Tags