Formulation, In Vitro Release and Iontophoresis Study of Fluconazole Hydrogel

Ashok A Hajare; Mahesh N Mali; Arun S Dange; Sushil M Sarvagod; Shweta V Patwardhan; Sachin T Kurane

Research Journal of Pharmaceutical Dosage Forms and Technology

ISSN

0975-4377 (Online)
0975-234X (Print)

Submit Article

Formulation, In Vitro Release and Iontophoresis Study of Fluconazole Hydrogel

Author(s): Ashok A Hajare, Mahesh N Mali, Arun S Dange, Sushil M Sarvagod, Shweta V Patwardhan, Sachin T Kurane

Email(s): aahajare@rediffmail.com

DOI: Not Available

Address: Ashok A Hajare*, Mahesh N Mali, Arun S Dange, Sushil M Sarvagod, Shweta V Patwardhan and Sachin T Kurane
Bharati Vidyapeeth College of Pharmacy, Kolhapur-416013, M.S., India
*Corresponding Author

Published In: Volume - 1, Issue - 3, Year - 2009

View HTML

View PDF

ABSTRACT:
Transdermal delivery of an antifungal drug Fluconazole in the form of hydrogels was formulated using polymers Carbopol 934 and Carbopol 940. The hydrogels were evaluated for various physicochemical parameters such as pH, viscosity, drug content, spreadibility and in-vivo skin irritation test. In-vitro drug release and permeation was studied using cellophane membrane and hairless rat skin, respectively using Franz Diffusion cell. The optimized formulations were studied for iontophoresis and for short term stability. Formulations showed drug content, spreadability and pH in the range of 95.32-99.56%, 13.32-15.16 g.cm/s and 7.2 to 7.5, respectively. From the in-vitro drug release study of hydrogels it can be concluded that drug:carbopol 934:carbopol 940 in the ratio 1:0.5:0.5 gave maximum release suggesting its usefulness as hydrogel formulation. The optimized hydrogel formulation showed complete absence of irritation and found to be stable for 45 days.

Keywords:

Cite this article:
Ashok A Hajare, Mahesh N Mali, Arun S Dange, Sushil M Sarvagod, Shweta V Patwardhan ,Sachin T Kurane. Formulation, In Vitro Release and Iontophoresis Study of Fluconazole Hydrogel. Research J. Pharma. Dosage Forms and Tech. 2009; 1(3):280-284 .

Cite(Electronic):
Ashok A Hajare, Mahesh N Mali, Arun S Dange, Sushil M Sarvagod, Shweta V Patwardhan ,Sachin T Kurane. Formulation, In Vitro Release and Iontophoresis Study of Fluconazole Hydrogel. Research J. Pharma. Dosage Forms and Tech. 2009; 1(3):280-284 . Available on: https://rjpdft.com/AbstractView.aspx?PID=2009-1-3-25

Recomonded Articles:

Isolation and evaluation of Basella alba linn. Leaf mucilage as release retardant in tablet formulation

Author(s): Yamunappa, Ravi Kumar, Pooja Shetty, Prathibha Suvarna, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00012.4 Access: Open Access Read More

Comparative Standardization of Two Marketed Preparation of Gulwel churna

Author(s): Swati Talokar, Rohan R Vakhariya, A.R Dhole

DOI: 10.5958/0975-4377.2017.00005.2 Access: Open Access Read More

Formulation Development and Evaluation of Buccal Patches of Aceclofenac for Gingivitis

Author(s): Puja Saha, Pratik Swarup Das

DOI: 10.5958/0975-4377.2017.00026.X Access: Open Access Read More

Formulation and Evaluation of Transdermal Patch of Aceclofenac

Author(s): Rakesh P. Patel, Grishma Patel, Hitesh Patel , Ashok Baria

DOI: Access: Open Access Read More

Formulation and Evaluation of Immediate Release Pravastatin Sodium Tablets

Author(s): Yamunappa, Ravi Kumar, Pooja Shetty, Prathibha Suvarna, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00014.8 Access: Open Access Read More

Microemulsion: A Current Review

Author(s): Sushant R. Jagtap, D.G Phadtare, R.B. Saudagar

DOI: 10.5958/0975-4377.2016.00021.5 Access: Open Access Read More

Formulation and Evaluation of Buccal Tablet of Rasagiline Mesylate

Author(s): Shilpa N. Shrotriya, Kishore N. Gujar, Bhakti R. Chorghe

DOI: Access: Open Access Read More

Formulation and Evaluation of Israpidine Extended Release Matrix Tablets

Author(s): Praveen Kumar Uppala, K. Atchuta Kumar, Murali Krishna, U. Upendra Rao

DOI: 10.5958/0975-4377.2016.00039.2 Access: Open Access Read More

Formulation, In Vitro Release and Iontophoresis Study of Fluconazole Hydrogel

Author(s): Ashok A Hajare, Mahesh N Mali, Arun S Dange, Sushil M Sarvagod, Shweta V Patwardhan ,Sachin T Kurane

DOI: Access: Open Access Read More

Glimepiride Micro balloons: A Novel Approach for Bioavailability Enhancement by Gastro-Retentive Floating Drug Delivery System

Author(s): Rutuja R. Shah, Rutuja S. Shah, Rohan R. Vakhariya

DOI: 10.5958/0975-4377.2017.00030.1 Access: Open Access Read More

Formulation and Evaluation of Effervescent Floating Tablets of Procainamide

Author(s): B. Saraswathi, R. Jagadeesh Reddy, P. Swathi, G. Manasa

DOI: 10.5958/0975-4377.2017.00025.8 Access: Open Access Read More

Design and Evaluation of Sustained Release Matrix Tablets of Ibuprofen

Author(s): Amit K. Jain, Rajput Rammulrajsinh, Pradeep Agrawal, Kinal patel

DOI: Access: Open Access Read More

Evaluation of Seed Mucilage of Hibiscus Sabdariffa Linn as Tablet Binder

Author(s): Ch. Anupama, P. Padmakumari, K. Abbulu, Arti Mohan, A. Ppratyusha

DOI: Access: Open Access Read More

A Review on Biocompatible Hydrogel: Formulation Aspect and Evaluation

Author(s): Shubham Tripathi, Somnath Patel, Ritesh Patel, Shraddha,Pushpendra, Sachin,Neetish, Mahendra, Kuldeep, Prashant, Rajesh Patel, Girish, Nitin, Tomanlal, Amrita Thakur, Mukta Agrawal, Ajazuddin, D. K. Tripathi, Amit Alexander

DOI: 10.5958/0975-4377.2018.00019.8 Access: Open Access Read More

Niosome - A Versatile Tool in Transdermal Drug Delivery

Author(s): Shashikant Chandrakar , Swarnalata Saraf

DOI: Access: Open Access Read More

Understanding the Concept of Mucoadhesive Drug Delivery System: A Novel Approach over Conventional Dosage Forms

Author(s): Umesh Kumar, Khuman Lal, Navneet Patel, Lekhraj, Jai Prakash, Omkar, Jai Prakash, Rakesh Gurjar, Achyutanand Gupta, Chandra Prakash, Mukta Agrawal, Ajazuddin, D. K. Tripathi, Amit Alexander

DOI: 10.5958/0975-4377.2018.00016.2 Access: Open Access Read More

Formulation and Evaluation of Modified Pulsincap Drug Delivery System for Chronotherapeutic Delivery of Montelukast Sodium

Author(s): V. Kalyani, K. Basanthi , T.E.G.K. Murthy

DOI: Access: Open Access Read More

Bicalutamide Tablets by Spray Dried Microspheres: An Approach to Enhance Solubility

Author(s): Rutuja R. Shah, Abhijeet Jadhav, Rohan R. Vakhariya

DOI: 10.5958/0975-4377.2017.00027.1 Access: Open Access Read More

A Short Review on the Formulation of Transdermal Dermal Drug Delivery System (TDDS)

Author(s): Alok Ranjan, Aishwarya Sahu, Akansha Yadav, Alka Payasi, Akash Jaiswal, Akshay Kumar, Akash Sahu, Ashwani Jangde, Chandrashekhar Nayak, Dev Kumar, Harshita Yarda, Mitali Sahu, Nokesh Sahu, Rajesh Patel, Nisha Nair, Mukta Agrawal, Ajazuddin, D. K. Tripathi, Amit Alexander

DOI: 10.5958/0975-4377.2018.00014.9 Access: Open Access Read More

Drug Dissolution Enhancement by Salt Formation: Current Prospects

Author(s): Gannu Praveen Kumar, S. Kiran Kumar

DOI: Access: Open Access Read More

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

RNI: Not Available
DOI: 10.5958/0975-4377