pH Sensitive Hydrogel: A Review

Vinutha B. V.; Sheeba F. R

doi:10.52711/0975-4377.2023.00031

Research Journal of Pharmaceutical Dosage Forms and Technology

ISSN

0975-4377 (Online)
0975-234X (Print)

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pH Sensitive Hydrogel: A Review

Author(s): Vinutha B. V., Sheeba F. R

Email(s): vinutha0816@gmail.com

DOI: 10.52711/0975-4377.2023.00031

Address: Vinutha B. V., Sheeba F. R.
Mallige College of Pharmacy, 71 Silvepura, Chikkabanavara, Post Bangalore - 560-090.
*Corresponding Author

Published In: Volume - 15, Issue - 3, Year - 2023

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ABSTRACT:
Hydrogels are three-dimensional cross-linked networks of polymer chains that can absorb and hold lots of water in the interstitial spaces between chains. Improving the safety efficacy ratio of existing drugs is a current challenge to be addressed rather than the development of novel drugs which involves much expense and time. The efficacy of drugs is affected by several factors such as their low aqueous solubility, unequal absorption along the gastrointestinal (GI) tract, risk of degradation in the acidic milieu of the stomach, low permeation of the drugs in the upper GI tract, systematic side effects, etc. This review aims to enlighten readers on the role of pH-sensitive hydrogels in drug delivery, their mechanism of action, swelling, and drug release as a function of pH change along the GI tract. The basis for the selection of materials, their structural features, physical and chemical properties, the presence of ionic pendant groups, and the influence of their pKavalues on the ionization, consequent swelling, and targeted drug release are also highlighted.

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Cite this article:
Vinutha B. V., Sheeba F. R. pH Sensitive Hydrogel: A Review. Research Journal of Pharmaceutical Dosage Forms and Technology. .2023; 15(3):189-7. doi: 10.52711/0975-4377.2023.00031

Cite(Electronic):
Vinutha B. V., Sheeba F. R. pH Sensitive Hydrogel: A Review. Research Journal of Pharmaceutical Dosage Forms and Technology. .2023; 15(3):189-7. doi: 10.52711/0975-4377.2023.00031 Available on: https://rjpdft.com/AbstractView.aspx?PID=2023-15-3-7

REFERENCES:
1.   Rosiak J.M, Yoshii F. Hydrogels, and their medical applications, Nuclear Instruments, and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms. 151 (1999) 56-64.
2.   El-Hefian E. A, Elgannoudi E.S, Mainal A,Yahaya A.H. Characterization of chitosan in acetic acid: Rheological and thermal studies. Turk. J.Chem, 34 (2010) 47-56.
3.   Khan A, Othman M.B.H, Razak K. A, Akil H.M. Synthesis and physicochemical investigation of chitosan PMAA-based dual-responsive hydrogels. J.Polym.Res. 20 (2013) 1-8.
4.   Wichterle O, Lim D. Hydrophilic gels for biological use. Nature. 185 (1960) 117 - 118.
5.   Peppas N, Bures P, Leobandung W, Ichikawa H. Hydrogels in pharmaceutical formulations. Eur. J Pharm Biopharm. 50 (2000) 27-46.
6.   Create P, Monvisade P. In vitro drug release profiles of pH-sensitive hydroxyethylacryl chitosan/sodium alginate hydrogels using paracetamol as a soluble model drug. Int. J. Biol. Macromol. 2017; 99:71-8.
7.   Park M.J, Hur S.M, Rhee H.K. Online estimation and control of polymer quality in a copolymerization reactor. AIChE Journal. 48 (2002) 1013-1021.
8.   Gibas I, Janik H. Review: synthetic polymer hydrogels for biomedical applications. Chem. Chem. Technol. 4 (2010) 297-304.
9.   Ganji F, Vasheghani-Farahani S, Vasheghani-Farahani E. Theoretical description of hydrogel swelling: a review. Iran Polym J. 19 (2010) 375-398.
10.   Yahia L, Chiarini N, Gritsch L, Motta F.L. History and applications of hydrogels. Biomed. Sci. 2015, 4, 1–23.
11.   Van Bemmelen J.M. Das hydrogel und das krystallinische hydrat des kupferoxyds. Z. Anorg. Chem. 1894, 5, 466–483.
12.   Kirschner C.M, AnsethK.S. Hydrogels in healthcare: From static to dynamic material microenvironments. Acta Mater. 2013, 61, 931–944.
13.   Danno A. Gel formation of an aqueous solution of polyvinyl alcohol irradiated by gamma rays from cobalt-60. J. Phys. Soc. Jpn. 1958, 13, 722–727.
14.   Nguyen Q.V, Huynh D.P, Park J.H, Lee D.S. Injectable polymeric hydrogels for the delivery of therapeutic agents: A review. Eur. Polym. J. 2015, 72, 602–619.
15.   Lin C.C, Metters A.T. Hydrogels in controlled release formulations: Network design and mathematical modeling. Adv. Drug Deliv. Rev. 2006, 58, 1379–1408.
16.   Gupta P, Vermani K, Garg S. Hydrogels: From controlled release to ph-responsive drug delivery. Drug Discov. Today. 2002, 7, 569–579.
17.   Ranga Rao K.V, Padmalatha Devi K. Swelling controlled-release systems: Recent developments and applications. Int. J. Pharm. 1988, 48, 1–13.
18.   Bencherif S.A, Siegwart D.J, Srinivasan A, Horkay F, Hollinger J.O, Washburn N.R, Matyjaszewski K. Nanostructured hybrid hydrogels prepared by a combination of atom transfer radical polymerization and free radical polymerization. Biomaterials. 2009, 30, 5270–5278.
19.   Das N, Preparation methods and properties of hydrogel: a review. Int.J. Pharm. Pharm. Sci. 5 (2013) 112-117.
20.   Hoffman A.S, Hydrogels for biomedical applications. Adv.drug deliv.Rev. 64 (2012) 18-23.
21.   Ullah F, Othman M.B.H, Javed F, Ahmad Z, Akil H.M. Classification, processing and application of hydrogels: A review. Mater. Sci. Eng. C. 2015, 57, 414–433.
22.   Silva R, Singh R, Sarker B, Papageorgiou D.G, Juhasz J.A, Roether J.A, Cicha I, Kaschta J, Schubert D.W, Chrissafis K. Hybrid hydrogels based on keratin and alginate for tissue engineering. J. Mater. Chem. B 2014, 2, 5441–5451.
23.   Bhattarai N, Gunn J, Zhang M. Chitosan-based hydrogels for controlled, localized drug delivery. Adv. Drug Deliv. Rev. 2010, 62, 83–99.
24.   Islam A, Yasin T, BanoI, Riaz M. Controlled release of aspirin from ph-sensitive chitosan/poly (vinyl alcohol) hydrogel. J. Appl. Polym. Sci. 2012, 124, 4184–4192.
25.   Samanta H.S, Ray S.K. Controlled release of tinidazole and theophylline from chitosan-based composite hydrogels. Carbohydr. Polym. 2014, 106, 109–120.
26.   Calo E, KhutoryanskiyV. Biomedical applications of hydrogels: A review of patents and commercial products. Eur. Polym. J. 2015, 65, 252–267.
27.   Cavallaro G, Gianguzza A, Lazzara G, Milioto S, Piazzese D. Alginate gel beads filled with halloysite nanotubes, Appl.Clay Sci. 72 (2013) 132-137.
28.   Cascone M, Maltinti S, Barbani N, Laus M. Effect of chitosan and dextran on the properties of poly (vinyl alcohol) hydrogels. J. Mater. Sci. 10 (1999) 431-435.
29.   Kenawy E. R, Kamoun E. Mahy Eldin M. S, El-Meligy M. A, Physically crosslinked poly (vinyl alcohol)- hydroxyethyl starch blend hydrogel membranes: Synthesis and characterization for biomedical applications, Arab. J. Chem. DOI (2015) In Press.
30.   Huang M.H, Yang M.C. Evaluation of glucan/poly (vinyl alcohol) blend wound dressing using rat models. Int.J. Pharm. 346 (2008) 38-46.
31.   Einerson N.J, Stevens K.R, Kao W.J. Synthesis and physicochemical analysis of gelatin-based hydrogels for drug carrier matrices. Biomaterials. 24 (2003) 509-523.
32.   Seeli D.S, Prabaharan M. Guar gum succinate as a carrier for colon-specific drug delivery. Int. J. Biol. Macromol. 2016, 84, 10–15.
33.   Qing G, Li M, Deng L,Lv Z, Ding P, Sun T. Smart Drug Release Systems Based on Stimuli-Responsive Polymers. Mini-Rev.Med.Chem. 13 (2013) 1369-1380.
34.   Razzak M.T, Darwis D. Irradiation of polyvinyl alcohol and polyvinyl pyrrolidone blended hydrogel for wound dressing. Radiat.Phys.Chem. 62 (2001) 107-113.
35.   Razzaghi-Kashani M, Hasankhani H, Kokabi M. Improvement in physical and mechanical properties of butyl rubber with montmorillonite organo-clay. Iran. Polym.J. 16 (2007) 671.
36.   Shalumon K, Anulekha K, Nair S V, Nair S, Chennazhi K, Jayakumar R. Sodium alginate/poly (vinyl alcohol)/nano ZnO composite nanofibers for antibacterial wound dressings. Int. J. Biol. Macromol. 49 (2011) 247-254.
37.   Pillai O, Panchagnula R. Polymers in drug delivery. Curr. Opin. Chem. Biol. 2001, 5, 447–451.
38.   Karimi M, Ghasemi A,Sahandi Zangabad P, Rahighi R, Moosavi Basri S.M, Mirshekari H, AmiriM, Shafaei Pishabad Z, Aslani A BozorgomidM, et al. Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems. Chem. Soc. Rev. 2016, 45, 1457–1501.
39.   Gupta P, Vermani K, Garg S. Hydrogels: From controlled release to ph-responsive drug delivery. Drug Discov. Today. 2002, 7, 569–579.
40.   Khan A, Othman M.B.H, Razak K.A, Akil H.M. Synthesis and physicochemical investigation of chitosan-pm-based dual-responsive hydrogels. J. Polym. Res. 2013, 20, 1–8.
41.   Qiu Y, Park, K. Environment-sensitive hydrogels for drug delivery. Adv. Drug Deliv. Rev. 2001, 53, 321–339.
42.   Pan L,Chorus A, Yu G, Wang Y, Isaacson S, Allen R, Shi Y, Dauskardt R, Bao Z. An ultra-sensitive resistive pressure sensor based on hollow-sphere microstructure induced elasticity in conducting polymer film. Nat. Commun. 2014, 5.
43.   Alvarez Lorenzo C, Bromberg L, Concheiro A. Light-sensitive intelligent drug delivery systems. Photochem. Photobiol. 2009, 85, 848–860.
44.   Jeong B, Gutowska A. Lessons from nature: Stimuli-responsive polymers and their biomedical applications. Trends Biotechnol. 2002, 20, 305–311.
45.   Namdeo M, Bajpai S.K, KakkarS. Preparation of a magnetic-field-sensitive hydrogel and preliminary study of its drug release behavior. J. Biomater. Sci. Polym. Ed. 2009, 20, 1747–1761.
46.   Huebsch N, Kearney C.J, Zhao X, Kim J, Cezar C.A, Suo Z, Mooney D.J. Ultrasound-triggered disruption and self-healing of reversibly cross-linked hydrogels for drug delivery and enhanced chemotherapy. Proc. Natl. Acad. Sci. USA 2014, 111, 9762–9767.
47.   Zardad A.Z,Choonara Y, du Toit L, Kumar P, Mabrouk M, Kondiah P, Pillay V. A review of Thermo and ultrasound-responsive polymeric systems for delivery of chemotherapeutic agents. Polymers. 2016, 8, 359.
48.   Schmaljohann D. Thermo- and pH-responsive polymers in drug delivery. Adv. Drug Deliv. Rev. 2006, 58, 1655–1670.
49.   Hezaveh H, Muhamad I.I. Controlled drug release via minimization of burst release in ph-response kappa-carrageenan/polyvinyl alcohol hydrogels. Chem. Eng. Res. Des. 2013, 91, 508–519.
50.   Herber S, Olthuis W, Bergveld P, Berg A. Exploitation of a pH-sensitive hydrogel for CO2 detection. In Proceedings of the Eurosensors XVII, European Conference on Solid-State Transducers, Guimaraes, Portugal, 21–24 September 2003.
51.   Guenther M, Wallmersperger T, Keller K, GerlachG. Swelling behavior of functionalized hydrogels for application in chemical sensors. In Intelligent Hydrogels; Sadowski, G., Richtering, W., Eds.; Springer: Cham, Switzerland, 2013; pp. 265–273.
52.   YuJ, Fan H, Huang J, Chen J. Fabrication and evaluation of reduction-sensitive supramolecular hydrogel based on cyclodextrin/polymer inclusion for injectable drug-carrier application. Soft Matter. 2011, 7, 7386–7394.
53.   Kim I.S, Oh I.J. Drug release from the enzyme-degradable and pH-sensitive hydrogel composed of glycidyl
54.   Ullah F, Othman M.B.H, Javed F, Ahmad Z, Akil H.M. Classification, processing and application of hydrogels: A review. Mater. Sci. Eng. C. 2015, 57, 414–433.
55.   Miyata T, Uragami T, Nakamae K. Biomolecule-sensitive hydrogels. Adv. Drug Deliv. Rev. 2002, 54, 79–98.
56.   Murakami Y, Maeda M. DNA-responsive hydrogels that can shrink or swell. Biomacromolecules. 2005, 6, 2927–2929.
57.   Abd El-Ghaffar M.A, Hashem M.S, El-Awady M.K, Rabie A.M. pH-sensitive sodium alginate hydrogels for riboflavin-controlled release. Carbohydr. Polym. 2012 ;89(2):667-75.
58.   Cochran S, Brockman. A cosmetic ingredient innovation for the stabilization and delivery of volatile fluorometer with cosmetic applications, J.Cosmet.Sci, 58 (2006) 413-419.
59.   Patravale V, Mandawgade S. Novel cosmetic delivery systems: an application update. Int.J.Cosmet.Sci. 30 (2008) 19-33
60.   Bai B,Li L, Liu Y, Liu H, Wang Z, You C. Preformed particle gel for conformance control: factors affecting its properties and applications. SPE Reservoir Evaluation and Engineering. 10 (2007) 415-422.
61.   Tongwa T, Nygaard R, Bai B. Evaluation of a nanocomposite hydrogel for water shut‐off in enhanced oil recovery applications: Design, synthesis, and characterization. J. Appl. Polym. Sci. 128 (2013) 787- 794.

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