Author(s): Shital V. Sonawane, Avish D. Maru, Mitesh P. Sonawane

Email(s): sonawaneshital97@gmail.com

DOI: 10.52711/0975-4377.2021.00049   

Address: Shital V. Sonawane*, Avish D. Maru, Mitesh P. Sonawane
Loknete Dr. J.D. Pawar College of Pharmacy, Manur, Tal-Kalwan-423501, Dist-Nashik, (MH) India.
*Corresponding Author

Published In:   Volume - 13,      Issue - 4,     Year - 2021


ABSTRACT:
Oral nanosuspension of ritonavir was prepared by antisolvent precipitation method using various polymers such as Eudragit RS100, Poloxamer 407, SLS and Methanol.The effect of eudragit RS100 and poloxamer 407 used stabilizer and SLS is surfactant was investigated on particle size and distribution, drug content, entrapment efficiency was observed. Ritonavir is having low solubility and low permeability drug belonging to class-IV according to BCS. Drug-excipient compatibility and amorphous nature of ritonavir drug is prepared nanosuspension was confirmed by FTIR, DSC and Motic microscope studies, respectively. The nanosuspension was further evaluated for drug content, saturation solubility study and entrapment efficiency. The average particle size of ritonavir nanaosuspensions formulas was observed from 0.006 µm to 0.017 µm. The studied in the solubility and dissolution rate there are the increase solubility and dissolution rate of ritonavir nanosuspension.


Cite this article:
Shital V. Sonawane, Avish D. Maru, Mitesh P. Sonawane. Development, Characterization and Evaluation of Ritonavir Nanosuspension Treatment of Antiretroviral Therapy. Research Journal of Pharmaceutical Dosage Forms and Technology. 2021; 13(4):297-4. doi: 10.52711/0975-4377.2021.00049

Cite(Electronic):
Shital V. Sonawane, Avish D. Maru, Mitesh P. Sonawane. Development, Characterization and Evaluation of Ritonavir Nanosuspension Treatment of Antiretroviral Therapy. Research Journal of Pharmaceutical Dosage Forms and Technology. 2021; 13(4):297-4. doi: 10.52711/0975-4377.2021.00049   Available on: https://rjpdft.com/AbstractView.aspx?PID=2021-13-4-6


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