Author(s): Rathor Shruti, Ram Alpana

Email(s): rathod.shruti@reddiffmail.com

DOI: Not Available

Address: Rathor Shruti1 *and Ram Alpana2
1* School of Pharmacy, Ckosey Engineering College, Lal Khadan, Bilaspur (C.G.)
2S.L.T.Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidhlaya, Bilaspur (C.G.)
Corresponding Author

Published In:   Volume - 1,      Issue - 3,     Year - 2009


ABSTRACT:
The objective of present study was to develop gelatin microsphere containing Benzophenone-3 (Benz-3) for topical delivery, evaluating the effect of stirring speed, Effect of polymer concentration and effect of cross linker (sugars) on particle size, surface morphology, microencapsulation efficiency and in vitro drug release. Gelatin microspheres were prepared using emulsion cum thermal gelation technique by dropping Benz-3 and cross linker containing solution of gelatin, into preheated Soya oil. The USP paddle method was selected to carry out the dissolution studies carried out in methanol at pH=5.5 (pH was adjusted by using 0.2M NaOH). It was found that the microspheres with fructose and sucrose have smooth surface having particle size 29.6µm and 80.63µm, respectively. But untreated and glucose treated microspheres have wavy surface with particle size 50.32 and 45.02µm. It was observed that untreated microspheres and microspheres crosslinked with cross linked sucrose showed faster release of drug although microspheres cross linked with fructose and glucose showed delayed release of drug. In vitro drug release data showed that the formulation cross linked with fructose was best for sustained release of Benz-3 due to 95% release of drug after 12 hrs with t50 and t70 of 400min and 560min, respectively. The release of Benz-3 was influenced by the different cross linkers. Drug release kinetic from the fructose cross linked microspheres corresponded best to the first order kinetics.


Cite this article:
Rathor Shruti, Ram Alpana. Formulation and Characterization of Biocompatible Microspheres of Benzophenone-3. Research J. Pharma. Dosage Forms and Tech. 2009; 1(3):222-225.

Cite(Electronic):
Rathor Shruti, Ram Alpana. Formulation and Characterization of Biocompatible Microspheres of Benzophenone-3. Research J. Pharma. Dosage Forms and Tech. 2009; 1(3):222-225.   Available on: https://rjpdft.com/AbstractView.aspx?PID=2009-1-3-12


Recomonded Articles:

Author(s): Gopal Rao M., M. A. Amutha Gnana Arasi, S. Jayaprakash, M. Arun Kumar, P. Kavitha

DOI:         Access: Open Access Read More

Author(s): Swati S Talokar, Rohan R Vakhariya

DOI: 10.5958/0975-4377.2017.00001.5         Access: Open Access Read More

Author(s): Akelesh T., R. Ramya, Venkatesh. P., Divya Jacob , R. Venkatnarayanan

DOI:         Access: Open Access Read More

Author(s): Doppalapudi Sandeep, A. P. Pratyusha, G. Sudheshna, K. Lakshmi prasanna, P. Sreekanth

DOI:         Access: Open Access Read More

Author(s): Dilip M. Kumbhar, Kailas K. Mali, Remeth J. Dias, Vijay D. Havaldar, Vishwajeet S. Ghorpade, Nitin H. Salunkhe.

DOI: 10.5958/0975-4377.2016.00036.7         Access: Open Access Read More

Author(s): Nisha Nair, Amrita Thakur, Mukta Agrawal, Juhi Thakur,Shubhangi Gupta, Bharti Sahu, Devendra kumar, Indu Rai, Jaya Sonkar, Kalyani Sahu, Kuldeep, Kailash Kumar, Muktanand, Nidhi Kaushik, Omkar Sahu, Somsunder Sahu, Umesh Kumar, D. K. Tripathi, Ajazuddin, Amit Alexander

DOI: 10.5958/0975-4377.2018.00017.4         Access: Open Access Read More

Author(s): Rutuja R. Shah, Abhijeet Jadhav, Rohan R. Vakhariya

DOI: 10.5958/0975-4377.2017.00027.1         Access: Open Access Read More

Author(s): Priya D. Khode, Tina B. Katre

DOI: 10.5958/0975-4377.2019.00034.X         Access: Open Access Read More

Author(s): Tapan Kumar Giri, Manish Desmukh, Animesh Jaiswal ,Dulal Krishna Tripathi

DOI:         Access: Open Access Read More

Author(s): M.S. Gambhire, S. Lilke , V.M. Gambhire

DOI:         Access: Open Access Read More

Author(s): SM Sarode, MK Kale, G Vidyasagar

DOI:         Access: Open Access Read More

Author(s): Manish P Patel, MM Patel, KN Patel, DR Patel,UL Patel

DOI:         Access: Open Access Read More

Author(s): Dhanashree R. Karade, Nivedita H. Patil, Dr. P. J. Shirote, Mrs. Bhavana Deshmane

DOI: 10.5958/0975-4377.2018.00031.9         Access: Open Access Read More

Author(s): Desale Kishor B. Darekar A.B., Saudagar R.B.

DOI: 10.5958/0975-4377.2016.00029.X         Access: Open Access Read More

Author(s): Tina Raju, Tanushree Sarkar, Bhagyashree S. Patil, Amol A. Raskar

DOI: 10.5958/0975-4377.2015.00038.5         Access: Open Access Read More

Author(s): B. Saraswathi, T. Satyanarayana, G. Manasa, Ch. Mounika, Md Sanakowsar, P. Gopi Chandh, K. Krishnaveni

DOI: 10.5958/0975-4377.2019.00013.2         Access: Open Access Read More

Author(s): A Chandy, Sudish Rai, A Manigauha, Suresh Sahu

DOI:         Access: Open Access Read More

Author(s): AL. Akilandeshwari , K. Elango, S. Daisy Chellakumari, S. Kishore Kumar

DOI:         Access: Open Access Read More

Author(s): Prasanta Kumar Choudhury, Padala Narasimha Murthy, Suvakanta Dash, Rana Mazumder, Dhruba Sankar Goswami

DOI:         Access: Open Access Read More

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0975-4377 


Recent Articles




Tags