Author(s): Sethi RK, Sahoo SK, Das PK, Barik BB

Email(s): ranjan_pharma@yahoo.com

DOI: Not Available

Address: Sethi RK*, Sahoo SK, Das PK and Barik BB
University Department of Pharmaceutical Sciences, Utkal University, Vani Vihar, Bhubaneswar – 751004
*Corresponding Author

Published In:   Volume - 2,      Issue - 1,     Year - 2010


ABSTRACT:
Eudragit RS microspheres containing Indinavir sulphate for oral use were prepared using two different dispersing agents: aluminium stearate and magnesium stearate, by solvent evaporation method. The effects of the type and concentration of the dispersing agents and the inner phase polymer concentration on the size of microspheres was studied. The morphology of microspheres was characterized by scanning electron microscopy. The surface of microspheres prepared with aluminium stearate was smoother and non-porous. When magnesium stearate was used as dispersing agents, the particle size of microspheres decreased. Increasing amounts of this dispersing agent led to the accumulation of their free particles onto the surfaces of the microspheres. The drug release from the microspheres was faster with the microspheres from aluminium stearate based on their hydrophobic structures. The encapsulation efficiency is more in case of aluminium stearate in comparison to magnesium stearate. Formulation containing aluminium stearate shows a more sustained effect than formulation containing magnesium stearate. This may due to fact that aluminium stearate is more hydrophobic in comparison to magnesium stearate.


Cite this article:
Sethi RK, Sahoo SK, Das PK, Barik BB. Effect of Dispersing Agent on the Characteristics of Eudragit Microspheres. Research J. Pharma. Dosage Forms and Tech. 2010; 2(1):67-71.


Recomonded Articles:

Author(s): Alok Ranjan, Aishwarya Sahu, Akansha Yadav, Alka Payasi, Akash Jaiswal, Akshay Kumar, Akash Sahu, Ashwani Jangde, Chandrashekhar Nayak, Dev Kumar, Harshita Yarda, Mitali Sahu, Nokesh Sahu, Rajesh Patel, Nisha Nair, Mukta Agrawal, Ajazuddin, D. K. Tripathi, Amit Alexander

DOI: 10.5958/0975-4377.2018.00014.9         Access: Open Access Read More

Author(s): Doppalapudi Sandeep, A. P. Pratyusha, G. Sudheshna, K. Lakshmi prasanna, P. Sreekanth

DOI:         Access: Open Access Read More

Author(s): A Chandy, Sudish Rai, A Manigauha, Suresh Sahu

DOI:         Access: Open Access Read More

Author(s): M.S. Gambhire, S. Lilke , V.M. Gambhire

DOI:         Access: Open Access Read More

Author(s): Priya Patel, Rohini Sahu, Renjil Joshi, Surabhi Armarkar,Tarannum Parveen, Narendra Pratap, Renuka Sahu, Pushpanjali Sahu, Dujram Sahu, Rupali Manikpuri, Madhav Patel, Tikeshwar Sahu, Bhupendra Rajak, Parmanand Sahu, Pooja Yadav, Mukta Agrawal, Ajazuddin, D. K. Tripathi, Amit Alexander

DOI: 10.5958/0975-4377.2018.00013.7         Access: Open Access Read More

Author(s): Gondkar S.B, Shewale Lankesh P., Saudagar R.B

DOI: 10.5958/0975-4377.2016.00020.3         Access: Open Access Read More

Author(s): Sapkal SR, Jaiswal SB, Chandewar AV, Gaikwad SB, Pathan AM

DOI:         Access: Open Access Read More

Author(s): Asma Sulthana, B. Ramu, G. Srikanth, Bigala Rajkamal

DOI: 10.5958/0975-4377.2016.00022.7         Access: Open Access Read More

Author(s): Abhijit Chormale, Dharmendra Mundhada, Rajesh Mujoriya

DOI: 10.5958/0975-4377.2015.00026.9         Access: Open Access Read More

Author(s): Prasanta Kumar Choudhury, Padala Narasimha Murthy, Suvakanta Dash, Rana Mazumder, Dhruba Sankar Goswami

DOI:         Access: Open Access Read More

Author(s): Nikunj Patel, Ashok Kumar P, Basavaraj, Tom Damien, Someshwara Rao B , Suresh V Kulkarni

DOI:         Access: Open Access Read More

Author(s): Choudhury A, Dash SK , Roy A, Bahadur S, Saha S, Das S

DOI:         Access: Open Access Read More

Author(s): Bhakti R. Chorghe, Swapnil T. Deshpande, Rohit D. Shah, Swati S. Korabu, Sagar V. Motarwar

DOI:         Access: Open Access Read More

Author(s): Kasani Harikrishna Gouda, V. Sai Kishore, N. Balaji, V. Vijaya Kumar, N. Raghuram

DOI:         Access: Open Access Read More

Author(s): Nirav Patel, Nagesh C., Chandrashekhar S., Patel Jinal, Jani Devdatt

DOI:         Access: Open Access Read More

Author(s): D. Varun , B.V.P. Deepthi, P.V. Ayodhya Neelima, G. Suma Latha, M. Srikar, B. Anuhya , V. Siva Lalitha

DOI:         Access: Open Access Read More

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0975-4377 


Recent Articles




Tags