Nanosponge is a targeted drug delivery system in that active pharmaceutical agent is respectively targeted to its site of action and not to the non-targeted organs, tissues or cells. Nanosponges modern effective drug carriers which decrease the problems of toxicity and increase bioavailability of both hydrophilic and hydrophobic drugs. Nanosponge is a modern drug delivery system, is one of the most promising approaches in the life science. Nanosponges are tiny mesh like structure, a three dimensional network and nanometric cavity. Nanosponges are highly porous in nature and they have ability to entrap active molecules. Cyclodextrins and other appropriate crosslinking agents in a specified ratio use for prepration of nanosponge. Nanosponges fast absorb in the body until they reach the specific target site, stick on the surface and release the drug in control manner. Nanosponge have a high drug loading capacity as compare to other nanocavity. Hence they have high stability, solubility and delayed release of actives. Specially nanosponge is use for a loading of low water soluble drug and targeting to its specific site, it’s a advantage of nanosponge. Nanosponge can deliver the drugs in different routes like oral, topical, parentral etc. and act as vehical t in the delivery of enzymes, proteins, vaccines and antibodies. Thise review explain the characteristic features (advantage and disadvantage), preparation methods, factors, characterization, and applications of nanosponges in the field of drug delivery.
Cite this article:
Manish Bandu Balwe. Nanosponge A Novel Drug Delivery System. Res. J. Pharma. Dosage Forms and Tech.2020; 12(4):261-266. doi: 10.5958/0975-4377.2020.00043.9
1. Trotta F, Cavalli R, Tumiatti W, Zerbinati O, Rogero C, Vallero R. Ultrasound-assisted synthesis of Cyclodextrin-based nanosponges. 2007; 786-841.
2. Vyas SP, Khar RK. Novel carrier systems. Targeted and controlled drug delivery, 1st ed., CBS publishers, New Delhi 2002, 332-413.
3. Nowack B. Nanosilver revisited downstream. Science., 2010, 330; 1054-1055.
4. Fabrega J, Fawcett SR, Renshaw JC, Lead JR. Silver nanoparticle impact on bacterial growth: effect of ph, concentration, and organic matter. Environ Sci Technol., 2009, 43; 7285-7290.
5. Nowack B, Krug HF, Height M. 120 years of nanosilver history: implications for policy makers. Environ Sci Technol., 2011, 45; 1177-1183.
6. Krishnamoorthy K, Rajappan M. Nanosponges: a novel class of drug delivery system-review. J Pharm Pharm Sci, 2012; 15(1): 103-11.
7. Vyas SP, Khar RK. Targeted and Controlled Drug Delivery- Novel Carrier Systems. Molecular Basis of Targeted Drug Delivery. CBS Publishers and Distributors; New Delhi, 2008; 38- 40.
8. Eki S., Lei T., Jingquan L., Zhongfan J., Cyrille B and Thomas PD. (2009) Biodegradable Star Polymers Functionalized With β-Cyclodextrin Inclusion Complexes. Bio macromolecules, 10(9): 2699–270.
9. Bolmal UB, Manvi FV, Rajkumar K, Palla SS, Paladugu A, Reddy KR. Recent advances in nanosponges as drug delivery system. Int J Pharm Sci Nanotechnol 2013;6: 1934-44.
10. Omar L, Julie L, Lutfiyl A, Jorge M, Stephanie R, Olivier T et al. Effects of sic nanoparticles orally administered in a rat model: Biodistribution, toxicity and elemental composition changes in feces and organs. Toxicol Appl Pharm., 2012, 264; 232-245.
11. Cavali R, Trotta F, Tumiatti V. Cyclodextrin based nanosponges for drug delivery. J Incl Phenom Macrocyl chem., 2006, 56; 209-213.Trotta F, Cavalli R, Tumiatti W, Zerbinati O, Rogero C, Vallero R. Inventors; Sea Marconi
12. Technologies Sas, assignee. Ultrasound assisted synthesis of cyclodextrin based nanosponges. EP 1786 841 B1. 2007.
13. Sharma R, Walker RB, Pathak K. Evaluation of the kinetics and mechanism of drug release from econazole nitrate nanosponges loaded carbopol hydrogel. Indian J Parm Edu Res., 2011, 45(1); 25-31.
14. Cavalli R, Rogero CM, Mognetti B, Berta GN, Tumiatti V, Trotta F. Inventors; Sea Marconi Technologies Sas, assignee. Cyclodextrin based nanosponges as a vehicle for antitumoral drugs. WO 2009/003656 A1. 2009 January 8.
15. Thakre AR, Gholse YN, Kasliwal RH. Nanosponges: a novel approach of drug delivery system. J Med Pharm Allied Sci 2016;78: 103-11.
16. Swaminathan S. Studies on novel dosage forms [dissertation]. Mumbai, Mumbai University, 2006.
17. Ajay V, Preetam N, Rajendra M, Swati T. Nanosponges: A Benefication For Novel Drug Delivery. Int J Pharm Tech Res., 2014, 6(1); 11-20.
18. F. Trotta, R. Cavalli, V. Tumiatti, O. Zerbinati, C. Roggero and R. Vallero, Ultrasound Assisted Synthesis of Cyclodextrin Based Nanosponges, EP Pat 1786841A1, 23May, 2007.
19. Selvamuthukumar, Subramanian et al. Nanosponges: A Novel Class of Drug Delivery System– Review. J Pharm Pharma Sci, 2012; 15(1): 103–111.
20. Girek, T., Ciesielski, W., 2010. Polymerization of beta-cyclodextrin with maleic anhydride along with thermogravimetric study of polymers. Journal of Inclusion Phenomena Macrocyclic Chemistry. Pp. 1-7.
21. Tejashri G, Amrita B, Darshana J. Cyclodextrin based nanosponges for pharmaceutical use: A review. Acta Pharm., 2013, 63; 335-358.
22. Ajay V et al, Nanosponges: A beneficationfor Novel Drug Delivery. Int J Pharm Tech Res., 2014, 6(1); 11-20.
23. Guo L, Gao G, Liu X, Liu F. Preparation and characterization of tio2 nanosponge. Mater Chem Phys.,2008, 111; 322-325.
24. Selvamuthukumar, Subramanian et al. Nanosponges: A Novel Class of Drug Delivery System – Review. J Pharm Pharma Sci, 2012; 15(1): 103–111.
25. Ansari KA, Torne SJ, Vavia PR, Trotta F, Cavalli R. Paclitaxel loaded nanosponges: in-vitro characterization and cytotoxicity study on MCF-7 cell line culture. Curr Drug Deliv. 8(2): 2011; 194-202.
26. Leslie Z and Benet, (2007), “Bioavailability and Bioequivalence: Focus on Physiological Factors and Variability”, Department of pharmaceutical sciences, University of California, San Francisco, USA.
27. Kerali S V, Machevas P. Van P A, and Shah V P. Bioavailibility and bioequivalence: Focus on physiological factors and variability. Pharmaceutical research, 2008; 1956-1962.
28. Sharma R et al, Evaluation of kinetics and mechanism of drug release from Econazole nitrate Nanosponges loaded carbopol Hydrogel. Indian J Pharma Edu Res 2011 ,45(1):25-31.
29. Embil K., and Nacht S., Themicrosponge delivery system atopical delivery system with reduced irritancy incorporating multiple triggering mechanisms for the release of actives. J Microencapsule, 1996, 13:575–8821.
30. Jenny A et al, Role of β- cyclodextrin nanosponges in polypropylene photooxidation, Carbohydrate Polymers, 2011; 86: 127– 135.
31. Embil K, Nacht S, The microsponge delivery system a topical delivery system with reduced irritancy incorporating multiple triggering mechanisms for the release of actives. J Microencapsule, 1996; 13: 575–88.
32. Vavia PR, Swaminathan S, Trotta F, Cavalli R. Application of nanosponges in drug delivery system. In proceeding XII international cyclodextrin symposium, 2006; 14-17.
33. Lala R et al , Current trends in β- cyclodextrin based drug delivery systems. Int J Res Ayur Pharm, 2011; 2(5): 1520-1526.
34. Rajeswari C, Alka A, Javed A, Khar R K. Cyclodextrins in drug delivery: an update review. AAPS pharmSci Tech, 2005; 6(2): E329-E357.
35. Rajeswari C, Alka A, Javed A, Khar R K. Cyclodextrins in drug delivery: an update review. AAPS pharmSci Tech, 2005; 6(2): E329-E357.
36. Prathima Srinivas et. al, Formulation and Evaluation of Isoniazid loaded nanosponges, Pharmaceutical Nanotechnology,2015, Vol.3, 68-76.
37. Tiwari H et al, A Review on Nanosponges, World Journal of Pharmacy and Pharmaceutical Sciences, 2014, volume-3, 219-233.
38. Swaminathan S et al, Invitro release modulation and conformational stabilization of a model protein using swellablepolyamidoamine nanosponges of cyclodextrin. J InclPhemonMacrocycl Chem., 2010, DOI10.1007/s10847-010-9765-9.
39. Schlichten mayer M and Hirscher M, J Mater Chem, 2012, 22, 10134-10143.
40. Cavalli R, Akhter AK, Bisazza A, Giustetto P, Trotta F, Vavia P. Nanosponge formulations as oxygen delivery systems. Int J Pharm., 2010, 402; 254-257.
41. Ansari KA, Torne SJ, Vavia PR, Trotta F, Cavalli R. Paclitaxel loaded nanosponges: in-vitro characterization and cytotoxicity study on MCF-7 cell line culture. Curr Drug Deliv. 8(2): 2011; 194-202.
42. A. Martin, J et al, In: Physical Pharmacy–Physical Chemical Principles in Pharmaceutical Sciences, 3 (1991) 527.
43. Vyas A, Saraf S. Cyclodextrin based novel drug delivery systems. J Incl Phenom Macrocycl Chem., 2008, 62; 23-42.