Author(s):
Urvish M. Choudhary, Rinku Y. Mistree, Disha N. Patel, Shreyas V. Desai, Naimish A. Patoliya, Chainesh N. Shah, Umesh Upadhyay
Email(s):
shreyasdesai707@gmail.com
DOI:
10.52711/0975-4377.2021.00033 
Address:
Urvish M. Choudhary1*, Rinku Y. Mistree1, Disha N. Patel1, Shreyas V. Desai1, Naimish A. Patoliya1, Dr. Chainesh N. Shah2, Dr. Umesh Upadhyay3
1B-Pharm Sigma Institute of Pharmacy, Bakrol, Ajwa, Vadodara - 390019 Gujarat, India.
2Associate Professor, Sigma Institute of Pharmacy, Bakrol, Ajwa, Vadodara - 390019 Gujarat, India.
3Principal, Bakrol, Ajwa, Vadodara - 390019 Gujarat, India.
*Corresponding Author
Published In:
Volume - 13,
Issue - 3,
Year - 2021
ABSTRACT:
The proposed study is focussed at developing Aceclofenacmicrosponges for topic drug delivery systems. QbD was applied for better understanding of the process and to generate design space, using quality target product profile, critical quality attributes, and risk assessment. The aim of the experiment was to prepare a safe, efficacious, stable and patient compliant microsponge dosage form of Aceclofenac. Materials and methods: Pre-formulation studies were carried out which helped in developing an accurate dosage form. UV, FTIR, DSC, and SEM studies were done for pre-formulation and post-formulation evaluations. These study deals with the design and optimization of Aceclofenacmicrosponges loaded topical drug delivery system to the controlled release of active drug into the skin in order to minimize the systemic exposure and minimize local cutaneous reactions to active drugs by DoE method of QbD Approach. AceclofenacMicrosponges were prepared by quasi emulsion solvent diffusion method using Eudragit-RS100 as a polymer, polyvinyl alcohol, Ethanol as Internal phase volume and Liquid paraffin as External phase volume. In this study, we found that the controlled release of aceclofenac microsponges.
Cite this article:
Urvish M. Choudhary, Rinku Y. Mistree, Disha N. Patel, Shreyas V. Desai, Naimish A. Patoliya, Chainesh N. Shah, Umesh Upadhyay. Formulation and Development of Aceclofenac loaded Microsponges Topical Drug Delivery System using quality by Design Approach. Research Journal of Pharmaceutical Dosage Forms and Technology. 2021; 13(3):185-2. doi: 10.52711/0975-4377.2021.00033
Cite(Electronic):
Urvish M. Choudhary, Rinku Y. Mistree, Disha N. Patel, Shreyas V. Desai, Naimish A. Patoliya, Chainesh N. Shah, Umesh Upadhyay. Formulation and Development of Aceclofenac loaded Microsponges Topical Drug Delivery System using quality by Design Approach. Research Journal of Pharmaceutical Dosage Forms and Technology. 2021; 13(3):185-2. doi: 10.52711/0975-4377.2021.00033 Available on: https://rjpdft.com/AbstractView.aspx?PID=2021-13-3-4
REFERENCES:
1. Lourenço V. et al. “A quality by design study applied to an industrial pharmaceutical fluid bed granulation” Eur. J. of Pharmaceutics and Biopharmaceutics.2012,81, 438–447.
2. Delasko J and Burke L, “Target Product Profile: Beginning Drug Development with the End in Mind.” Update.2005, 2(3), 34-41.
3. Singh P, Sihorkar V, Jaitly V, Kanaujia P and Vyas S,“Pilosebaceous unit: anatomical considerations and drug delivery opportunities.” 2002, 32, 269-281.
4. Kaparissides C, Alexandridou S, Kotti K and Chaitidou S, “Recent Advances in Novel Drug Delivery Systems.”J. of Nanotechnology Online. 2006, 1(3), 55-58.
5. Newton D,“Biotechnology Frontier: Targeted Drug Delivery.” US Pharmacist.1991, 16, 38-39, 43-44, 46-48, 50-51.
6. Kydonieus A and Berner B, “Transdermal Delivery of Drugs.” CRC Press, Boca Raton.1987, Lewis G and Phan R, “Pharmaceutical Experimental Design.” New York.1999, 265-276.
7. Delattre L and DelneuvilleI, “Biopharmaceutical aspects of the formulation of dermatological vehicles.” J. Eur. Acad. Dermatol. Venereol. 1995, 5,70-71.
8. NachtS, “TheMicrosponge: A Novel Topical Programmable Delivery System, In: Topical Drug Delivery Systems.” Edited by David W. O. and Anfon H. A. (1992),42, 299-325.
9. Netal A, Amrita B and Madhu M, “Development of Microsponges for Topical Delivery of Mupirocin.” AAPS Pharm. SciTech. 2009, 10(2), 402-409.
10. Vikas J and Ranjit S, “Dicyclomine-loaded Eudragit®-based Microsponge with Potential for Colonic Delivery: Preparation and Characterization.” Tropical J. Pharma. Res. 2010, 9 (1), 67-72.
11. Viral S, “Microsponge drug delivery system: A review.” Int. J. Res. Pharm. Sci.2010, 1, 212-218.
12. Ajay S, “Microsponge drug delivery system as an innovation.” Asian J. of Pharmaceutical Edu. and Res. 2012, 1(2), 10-17.
13. Srivastav R, Deepesh K and Kamla P, “Colonic luminal surface retention of meloxicam microsponges delivered by erosion-based colon-targeted matrix tablet.” Int. J. of Pharmaceutics. 2012, 427, 153– 162.
14. Yerram C, Shaik F, Rajalakshmi R, Amaravathi V, Rubia B, Yasmeen1 R and Naveen C, “Preparation And Evaluation of Microsponge Loaded Controlled Release Topical Gel of Acyclovir Sodium.” Int. J. of Biopharmaceutics. 2012, 3(2), 96-102.
15. Swetha A, Gopal R and Venkata R, “Formulation and in-vitro Evaluation of EtodolacEntrapped in Microsponge based Drug Delivery System.” Int. J. Pharma. 2011, 1(2), 73- 80.
16. Sabya S. Santanukaity, Somasreeray, Biswanathsa, “Development and evaluation of xanthan gum-facilitated ethyl cellulose microsponges for controlled percutaneous delivery of diclofenac sodium.” ActaPharm. 2011, 1(4), 257–270.
17. Vikas J and Ranjit S, “Dicyclomine-loaded Eudragit®-based Microsponge with Potential for Colonic Delivery: Preparation and Characterization.” Tropical J. Pharma. Res. 2010, 9 (1), 67-72.
18. Jain N and Misra A, “Controlled and Novel Drug Delivery.” CBS Publishers and Distributors. New Delhi. 2005, 101-106.
19. Nokhodchi A and Jelvehgari M, “Factors affecting the morphology of benzoyl peroxide microsponges.” Micron. 2007, 38, 834-840.
20. Jelvehgaria M and Siahi-Shadbada M, “The MDS of benzoyl peroxide: Preparation, characterization and release studies.” Int. J. of Pharmaceutics. 2006, 308,124–132.
21. Orlu M and Araman A, “Design and Evaluation of Colon SpecificDrug Delivery System Containing Flurbiprofen Microsponges.” Int. J. Pharm. 2006, 318,103-117.
22. Maiti S and Dey P, “Investigation on Processing Variables for the Preparation of Fluconazole- Loaded Ethyl Cellulose Microspheres by Modified Multiple Emulsion Technique.” AAPS Pharm. Sci Tech.2009, 10(3), 703– 715.
23. Costa P and Lobo J, “Modeling and comparision of dissolution profiles.” European journal of pharmaceutical science and research.2009, 4, 48-54.
24. Lokhandwala H, Deshpande A and Deshpande S, “Kinetic modeling and dissolution profiles Comparison: an overview.” International Journal of Pharma and Bio Sciences.2013,4, 728 – 737.
25. Higuchi T, “Mechanism of sustained action medication. Theoretical analysis of rate of release of solid drugs dispersed in solid matrices.” J. of Pharmaceutical Sci.1963, 52, 1145-1149.
26. Hixson A and Crowell J, “Dependence of reaction velocity upon surface and agitation: I-theoretical consideration.” Indian engineering chemistry.1931, 23, 923-931.
27. Korsmqer R and Gumy R, “Mechanisms of solute release from porous hydrophilic polymers.” Int. J. of Pharmaceutics.1983, 15, 25-35.
28. Sanjay B, Devendra J, Amol P, Krishna P and VinodM, “Formulation, development and evaluation of Fluconazole gel in various polymers bases.” Asian J. of Pharmaceutics. 2007, 1(1), 63-68.
29. Rohit R Shah, Chandrakant S Magdum. Fluconazole topical micro emulsion: preparation and evaluation. Res J Pharm and Technol 2009; 2(2): 213-216.
30. Lalitkumar, Ruchiverma. In vitro evaluation of Fluconazole topical gel prepared using natural polymer. Int J Drug Del 2010;2(6): 58-63.