Author(s): Ashok Thulluru, Narahari N Palei, M. Vimala, M. Vidyasagar, K. Vishnupriya

Email(s): ashokthulluru@gmail.com

DOI: 10.5958/0975-4377.2018.00022.8   

Address: Ashok Thulluru*, Narahari N Palei, M. Vimala, M. Vidyasagar, K. Vishnupriya
Sree Vidyanikethan College of Pharmacy, A. Rangampet, Tirupati-517102, A. P.
*Corresponding Author

Published In:   Volume - 10,      Issue - 3,     Year - 2018


ABSTRACT:
Optimized taste masked orally disintegrating tablets (ODTs) containing Zolpidem Tartrate (ZT) were prepared by direct compression method. Three factors, two levels (23) full factorial design was used to optimize the effect of taste masking agent (EudragitE100; X1); superdisintegrant: Crospovidone (CPV; X2) and solid binder: Hydroxy propyl cellulose (HPC; X3) on tablet properties: Disintegration time (DT; Y1) and % of ZT dissolved within 15 min (D15; Y2). A composite was prepared by mixing ethanolic solution of ZT and Eudragit E100 with mannitol prior to mixing with other tablet ingredients. The prepared ODTs were characterized for pre- and post- compression studies (wt. variation, hardness, friability, wetting time and assay). The prepared ODTs were complying with the pharmacopoeial guidelines regarding the pre- and post- compression parameters. EudragitE100 (X1) had no significant effect on tablet DT (Y1) and D15(Y2). However, the effects of both CPV(X2) and HPC (X3) on ODTs DT (Y1) and D15 (Y2) were significant (p<0.05). The formulation F3 (3% Eudragit E100, 5% CPV and 1%HPC) showing lesser DT (13.38 sec) and higher D15 (84.18%) is an optimized taste masked ZT ODT, which passed the stability test as per ICH guidelines.


Cite this article:
Ashok Thulluru, Narahari N Palei, M. Vimala, M. Vidyasagar, K. Vishnupriya. Quality By Design approach to optimize the taste masked Zolpidem tartrate Oral Disintegrating Tablets. Res. J. Pharma. Dosage Forms and Tech.2018; 10(3):139-148. doi: 10.5958/0975-4377.2018.00022.8


Recomonded Articles:

Author(s): Dipti G. Phadtare, Amol R. Pawar, R.B. Saudagar, Govind K.Patil

DOI: 10.5958/0975-4377.2017.00002.7         Access: Open Access Read More

Author(s): Domendra Sahu, Shekhar Verma , Ravindra D. Dubey

DOI:         Access: Open Access Read More

Author(s): V. S. Parmar, S.C. Shivhare

DOI:         Access: Open Access Read More

Author(s): Yamunappa, Ravi Kumar, Pooja Shetty, Prathibha Suvarna, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00012.4         Access: Open Access Read More

Author(s): Gopal Rao M., M. A. Amutha Gnana Arasi, S. Jayaprakash, M. Arun Kumar, P. Kavitha

DOI:         Access: Open Access Read More

Author(s): A Maru, U Pattamatta , VB Patravale

DOI:         Access: Open Access Read More

Author(s): Hapse S.A., Bhagat B.V., Wagh V.S. , Kadaskar P.T.

DOI:         Access: Open Access Read More

Author(s): Vinod K.R., Sandhya S

DOI:         Access: Open Access Read More

Author(s): Swapnil T. Deshpande, P. S. Vishwe, Rohit D. Shah, Swati S. Korabu, Bhakti R. Chorghe, DG Baheti

DOI:         Access: Open Access Read More

Author(s): Debarupa Dutta, Prithviraj Chakraborty

DOI:         Access: Open Access Read More

Author(s): Simila Madathil, RaviKumar, Anju Govind, Mercy Mathew, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00013.6         Access: Open Access Read More

Author(s): Patil Namrata D., Gondkar S.B., Saudagar R.B.

DOI: 10.5958/0975-4377.2016.00033.1         Access: Open Access Read More

Author(s): Dilip M. Kumbhar, Kailas K. Mali, Remeth J. Dias, Vijay D. Havaldar, Vishwajeet S. Ghorpade, Nitin H. Salunkhe.

DOI: 10.5958/0975-4377.2016.00036.7         Access: Open Access Read More

Author(s): Chirag A. Patel, Priyal R. Patel, Dhrubo Jyoti Sen,Jayvadan K. Patel

DOI:         Access: Open Access Read More

Author(s): Hardik B. Rana, Kajol Patel, Mansi Dholakia, Vaishali T. Thakkar, Mukesh C. Gohel, Tejal R. Gandhi

DOI: 10.5958/0975-4377.2017.00006.4         Access: Open Access Read More

Author(s): Dharmendra Kumar Kushwah, Prakash Yashwant Kohle, Bimal Kumar Srivastava, Manoj Parmar ,Dhaval Mehta

DOI:         Access: Open Access Read More

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0975-4377 


Recent Articles




Tags