Author(s): DG Umalkar, GV Shinde, GS Bangale, Rajesh KS, RSR Murthy

Email(s): duatujwalpharm@yahoo.co.in

DOI: Not Available

Address: DG Umalkar1*, GV Shinde1, GS Bangale1, Rajesh KS2 and RSR Murthy2
1Parul Institute of Pharmacy, Limda, Vadodara-391760, Gujarat, India
2Indo Soviet Friendship College of Pharmacy, Ghalkalan Moga Punjab.
*Corresponding Author:

Published In:   Volume - 2,      Issue - 2,     Year - 2010


ABSTRACT:
In the present work, Orodispersible tablet of Aceclofenac were designed with a view to Enhance patient compliance. A combination of super-disintegrants i.e.Ac-di-sol (Croscarmellose sodium), Polyplasdone XL-10, Microcrystalline Cellulose pH 102 was Used along with directly compressible dextrose to enhance mouth feel. The prepared Batches of tablet were evaluated for hardness, friability, drug content uniformity, wetting time, water absorption ratio and in vitro dispersion time. Based on in vitro dispersion time, two formulation were tested for in vitro drug release pattern (in pH7.4phosphatebuffer), short – term stability at 250C 20C/60% RH, 300C 20C/65% RH, 400C 20C/75% RH for 3 month and drug –excipient interaction (IR Spectroscopy) among the two formulation, the formulation prepared by direct Compression method using Ac-di-sol (croscarmellose sodium) 50mg, Polyplasdone XL- 10 -25mg, Microcrystalline Cellulose pH 102- 25mg was found tobe better formulation T80% = 5 min. based on in- vitro drug release characteristics. Short term stability studies on the formulation indicated that there is no significant change in drug content and in vitro dispersion time


Cite this article:
DG Umalkar, GV Shinde, GS Bangale, Rajesh KS, RSR Murthy. Design and Evaluation of Orodispersible Tablet of Aceclofenac Using Different Superdisintegrants by 23 Factorial Designs. Research J. Pharma. Dosage Forms and Tech. 2010; 2(2):198-203 .


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