Author(s): DS Saindane, AS Kulkarni, AN Sagri, RB Pimprikar, SB Yeshwante, CP Suryawanshi, SD Firke, MK Kale

Email(s): dhananjay.saindane@gmail.com

DOI: Not Available

Address: DS Saindane*1, AS Kulkarni, AN Sagri, RB Pimprikar2, SB Yeshwante2, CP Suryawanshi2, SD Firke3, MK Kale3
1Department of Pharmaceutical Chemistry, Govt. College of Pharmacy, Karad, (M.S.)
2 Gangamai College of Pharmacy, Nagaon, Dhule(M.S.)
3 KYDSCT’s College of Pharmacy, Sakegaon, Tal. Bhusawal, Dist. Jalgaon (M.S.)
*Corresponding Author

Published In:   Volume - 1,      Issue - 2,     Year - 2009


ABSTRACT:
This study compares the physicochemical properties of cefixime (CFX) solid dispersions prepared by freeze drying method. Solid dispersions of cefixime in poloxamer 188 were prepared and characterized by intrinsic dissolution, powder X-ray diffraction, Fourier transform infrared spectroscopy and Scanning electron microscopy. CFX:Poloxamer 188 solid dispersions showed increased dissolution rate than pure CFX. The Infrared spectroscopic studies showed interaction between CFX and Poloxamer 188 in solid dispersions. The scanning electron microscopy studies showed decrease in particle size of binary system as compared to particle of pure drug. The amorphous state of CFX coupled with presence of interaction between drug and Poloxamer 188. However, the antimicrobial activity of CFX was increased significantly by Poloxamer 188 against S. aureus and E. coli. The solid dispersion technique of CFX:Poloxamer 188 binary system provides a promising way to increase the solubility and dissolution rate of poorly soluble drugs.


Cite this article:
DS Saindane, AS Kulkarni, AN Sagri, RB Pimprikar, SB Yeshwante, CP Suryawanshi, SD Firke, MK Kale. Physicochemical Characterization of Solid Dispersion of Cefexime with Poloxamer 188. Research J. Pharma. Dosage Forms and Tech. 2009; 1(2): 162-166.

Cite(Electronic):
DS Saindane, AS Kulkarni, AN Sagri, RB Pimprikar, SB Yeshwante, CP Suryawanshi, SD Firke, MK Kale. Physicochemical Characterization of Solid Dispersion of Cefexime with Poloxamer 188. Research J. Pharma. Dosage Forms and Tech. 2009; 1(2): 162-166.   Available on: https://rjpdft.com/AbstractView.aspx?PID=2009-1-2-20


Recomonded Articles:

Author(s): Yamunappa, Ravi Kumar, Pooja Shetty, Prathibha Suvarna, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00012.4         Access: Open Access Read More

Author(s): Rakesh P. Patel, Grishma Patel, Hitesh Patel , Ashok Baria

DOI:         Access: Open Access Read More

Author(s): Chirag A. Patel, Priyal R. Patel, Dhrubo Jyoti Sen,Jayvadan K. Patel

DOI:         Access: Open Access Read More

Author(s): Swati Talokar, Rohan R Vakhariya, A.R Dhole

DOI: 10.5958/0975-4377.2017.00005.2         Access: Open Access Read More

Author(s): Sushant R. Jagtap, D.G Phadtare, R.B. Saudagar

DOI: 10.5958/0975-4377.2016.00021.5         Access: Open Access Read More

Author(s): Yamunappa, Ravi Kumar, Pooja Shetty, Prathibha Suvarna, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00014.8         Access: Open Access Read More

Author(s): K Sonu Sharma, Rashmi Sharma, G Vidya Sagar

DOI:         Access: Open Access Read More

Author(s): Alok Ranjan, Aishwarya Sahu, Akansha Yadav, Alka Payasi, Akash Jaiswal, Akshay Kumar, Akash Sahu, Ashwani Jangde, Chandrashekhar Nayak, Dev Kumar, Harshita Yarda, Mitali Sahu, Nokesh Sahu, Rajesh Patel, Nisha Nair, Mukta Agrawal, Ajazuddin, D. K. Tripathi, Amit Alexander

DOI: 10.5958/0975-4377.2018.00014.9         Access: Open Access Read More

Author(s): V. Saikishore, G. Srikanth, Ch. Pooja, Y. Mrudula, R. Pavani, Ch. Jyosthna , C. Mayuren

DOI:         Access: Open Access Read More

Author(s): Nakkala Balaji , V. Sai Kishore , Kasani Hari Krishna Gouda

DOI:         Access: Open Access Read More

Author(s): Amit K. Jain, Rajput Rammulrajsinh, Pradeep Agrawal, Kinal patel

DOI:         Access: Open Access Read More

Author(s): Rutuja R. Shah, Abhijeet Jadhav, Rohan R. Vakhariya

DOI: 10.5958/0975-4377.2017.00027.1         Access: Open Access Read More

Author(s): Ashok A Hajare, Mahesh N Mali, Arun S Dange, Sushil M Sarvagod, Shweta V Patwardhan ,Sachin T Kurane

DOI:         Access: Open Access Read More

Author(s): Ch. Anupama, P. Padmakumari, K. Abbulu, Arti Mohan, A. Ppratyusha

DOI:         Access: Open Access Read More

Author(s): Kamal Arora, Ish Grover, Amit Chandna, Manish Devgan

DOI: 10.5958/0975-4377.2015.00017.8         Access: Open Access Read More

Author(s): Tushar D. Sonawane, Rajesh Z. Mujoriya

DOI: 10.5958/0975-4377.2016.00023.9         Access: Open Access Read More

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0975-4377 


Recent Articles




Tags