Author(s): Shiva Srikrishna, Kasula Sadhana, Ramya Sri S

Email(s): shivasrikrishna2@gmail.com

DOI: 10.52711/0975-4377.2023.00005   

Address: Shiva Srikrishna1*, Kasula Sadhana1, Ramya Sri S2
1Department of Pharmaceutics, Samskruti College of Pharmacy, Affiliated to JNTUH University, Hyderabad 501301, Telangana, India.
2Department of Pharmacy, University College of Technology, Osmania University, Hyderabad - 500007, Telangana, India.
*Corresponding Author

Published In:   Volume - 15,      Issue - 1,     Year - 2023


ABSTRACT:
In the present research work, we have designed a pulsatile formulation of Bosentan to treat High blood pressure as per the chronotherapeutic pattern of the disease. Core tablets were prepared by incorporating different concentration of disintegrants and were compressed in between different concentration of polymers. The core and compression coated tablets were subjected to pre-formulation, physicochemical and In-vitro drug release studies. FTIR studies revealed that there was not any chemical reaction between pure drug Bosentan and polymers. The pre and post-compressional parameters of tablets were also found to be within limits. Our optimized formulation F-6 releases Bosentan after a lag time of 2 hours and 98.01 % up to 12 hours. Formulations were stable for at least 3 months under standard long-term and accelerated storage conditions.


Cite this article:
Shiva Srikrishna, Kasula Sadhana, Ramya Sri S. Formulation and Evaluation of Bosentan Pulsatile Drug Delivery System by using Press Coated Technique. Research Journal of Pharmaceutical Dosage Forms and Technology.2023; 15(1):25-0. doi: 10.52711/0975-4377.2023.00005

Cite(Electronic):
Shiva Srikrishna, Kasula Sadhana, Ramya Sri S. Formulation and Evaluation of Bosentan Pulsatile Drug Delivery System by using Press Coated Technique. Research Journal of Pharmaceutical Dosage Forms and Technology.2023; 15(1):25-0. doi: 10.52711/0975-4377.2023.00005   Available on: https://rjpdft.com/AbstractView.aspx?PID=2023-15-1-5


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2.    Kalyani Lingamaneni, Mukthinuthalapati Mathrusri Annapurna. Development and validation of a new stability indicating RP-UFLC method for the estimation of Bosentan. Research Journal of Pharmacy and Technology. 2021; 14(8):4445-1. doi: 10.52711/0974-360X.2021.00772
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