Author(s): Gannu Praveen Kumar, S. Kiran Kumar

Email(s): ghalo2010@gmail.com

DOI: Not Available

Address: Gannu Praveen Kumar1* and S. Kiran Kumar2
1Department of Industrial Pharmacy, St. Peter’s Institute of Pharmaceutical Sciences, Warangal
2Talla Padmavathi College of Pharmacy, Warangal
*Corresponding Author

Published In:   Volume - 3,      Issue - 6,     Year - 2011


ABSTRACT:
Salt formation is the most common and effective method of increasing solubility and dissolution rates of acidic and basic drugs. The physicochemical principles of salt solubility and the influence of PH solubility profiles of acidic and basic drugs on salt formation and dissolution are discussed. The solubility of salts of acidic or basic drugs depends on how easily they dissociate into their free acid or base forms and on interrelationships of several factors, such as intrinsic solubility, PH, Pka, solubility product and maximum solubility in different dissolution media of varying PH. The interrelationships of these factors are elaborated and their influence on salt screening and the selection of optimal salt forms for development are explained. Salt screening is increasingly being adapted to high throughput experimentation, to shortlist the potential salt(s) for a comprehensive biopharmaceutical characterization at the scale up stage. The suitable salt form is then processed to the next stage of drug development.


Cite this article:
Gannu Praveen Kumar, S. Kiran Kumar. Drug Dissolution Enhancement by Salt Formation: Current Prospects. Research J. Pharma. Dosage Forms and Tech. 2011; 3(6): 251-259.

Cite(Electronic):
Gannu Praveen Kumar, S. Kiran Kumar. Drug Dissolution Enhancement by Salt Formation: Current Prospects. Research J. Pharma. Dosage Forms and Tech. 2011; 3(6): 251-259.   Available on: https://rjpdft.com/AbstractView.aspx?PID=2011-3-6-3


Recomonded Articles:

Author(s): Yamunappa, Ravi Kumar, Pooja Shetty, Prathibha Suvarna, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00012.4         Access: Open Access Read More

Author(s): Kritika Kanoujia, Chandraprabha Dewangan, Ayushi Masih, Dipti Sinha, Divya Oraon, Manisha Jaiswal, Monika Sahu, Ranjeeta Kumari, Sapna Pradhan, Ravi Suman, Rajkishan Dewangan, Roman Banjare, Pradeep Paikra, Mukesh Rawtiya, Mukta Agrawal, Ajazuddin, D. K. Tripathi, Amit Alexander

DOI: 10.5958/0975-4377.2018.00015.0         Access: Open Access Read More

Author(s): Rakesh P. Patel, Grishma Patel, Hitesh Patel , Ashok Baria

DOI:         Access: Open Access Read More

Author(s): Chirag A. Patel, Priyal R. Patel, Dhrubo Jyoti Sen,Jayvadan K. Patel

DOI:         Access: Open Access Read More

Author(s): Sayad Basha.K, Sheema Nafees. S, Nethravani. G, Thirumalesh Naik S.B

DOI: 10.5958/0975-4377.2016.00015.X         Access: Open Access Read More

Author(s): Swati Talokar, Rohan R Vakhariya, A.R Dhole

DOI: 10.5958/0975-4377.2017.00005.2         Access: Open Access Read More

Author(s): Sushant R. Jagtap, D.G Phadtare, R.B. Saudagar

DOI: 10.5958/0975-4377.2016.00021.5         Access: Open Access Read More

Author(s): Rajkumar Prasad Yadav, F. R. Sheeba

DOI: 10.52711/0975-4377.2021.00023         Access: Open Access Read More

Author(s): Shubham Tripathi, Umesh kumar Sahu, JyotsanaMeshram, RanjeetaKumari, D.K Tripathi, Ajazuddin, Amit Alexander, Harish Sharma, Gyanesh Kumar Sahu

DOI: 10.5958/0975-4377.2018.00009.5         Access: Open Access Read More

Author(s): Yamunappa, Ravi Kumar, Pooja Shetty, Prathibha Suvarna, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00014.8         Access: Open Access Read More

Author(s): Omprasad Nayakal, Prajakta Patil, Mangesh Bhutkar, Dheeraj Randive, Somnath Bhinge

DOI: 10.5958/0975-4377.2018.00032.0         Access: Open Access Read More

Author(s): Sandeep Gupta, Dheeraj Ahirwar, Neeraj K Sharma, Deenanath Jhade

DOI:         Access: Open Access Read More

Author(s): AM Avachat, SB Bhise

DOI:         Access: Open Access Read More

Author(s): Alok Ranjan, Aishwarya Sahu, Akansha Yadav, Alka Payasi, Akash Jaiswal, Akshay Kumar, Akash Sahu, Ashwani Jangde, Chandrashekhar Nayak, Dev Kumar, Harshita Yarda, Mitali Sahu, Nokesh Sahu, Rajesh Patel, Nisha Nair, Mukta Agrawal, Ajazuddin, D. K. Tripathi, Amit Alexander

DOI: 10.5958/0975-4377.2018.00014.9         Access: Open Access Read More

Author(s): Samadhan K. Deore, Rajendra K Surawase, Avish Maru

DOI: 10.5958/0975-4377.2019.00045.4         Access: Open Access Read More

Author(s): V. Saikishore, G. Srikanth, Ch. Pooja, Y. Mrudula, R. Pavani, Ch. Jyosthna , C. Mayuren

DOI:         Access: Open Access Read More

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

RNI: Not Available                     
DOI: 10.5958/0975-4377 


Recent Articles




Tags