Author(s): Patel Geeta M, Patel Madhabhai M

Email(s): geekhappy2002@yahoo.co.in

DOI: Not Available

Address: Patel Geeta M1* and Patel Madhabhai M2
1Department of Pharmaceutics and Pharmaceutical Technology, S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Kherva-382711. Gujarat, India.
2Kalol Institute of Pharmacy, Kalol, Gujarat, India
*Corresponding Author

Published In:   Volume - 1,      Issue - 3,     Year - 2009


ABSTRACT:
To develop more effective treatment for bacterial vaginosis, metronidazole was formulated in acid buffering bioadhesive tablet formulations that increase the time of contact of drug with the vaginal mucosa. Oral metronidazole is still the drug of choice in the treatment of bacterial vaginosis. Yet, side effects have been reported, and dosage as well as duration of therapy is still controversial. This study presents a possible alternative treatment using a single dose of metronidazole administered in a vaginal bioadhesive table. Double blind, randomized, clinical trials with 24 patients was carried out. The cure rate in acid buffering bioadhesive metronidazole vaginal tablet group was higher (86.66%) than metronidazole vaginal tablet (60%). No side effects were reported. Treatment of bacterial vaginosis with a single application of metronidazole in a bioadhesive vaginal tablet was found to be a valid alternative. These results indicate that a new bioadhesive vaginal tablet formulations might be further developed for safe convenient and effective treatment of bacterial vaginosis.


Cite this article:
Patel Geeta M, Patel Madhabhai M. Efficacy of Novel Acid Buffering Vaginal Tablet of Metronidazole for Bacterial Vaginosis. Research J. Pharma. Dosage Forms and Tech. 2009; 1(3):188 - 190.


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