Volume No. : 4
Issue No. : 3
Year : 2012
ISSN Print : 0975-234X
ISSN Online : 0975-4377
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Vivek Majethiya, Chandrashekhara S.*, Nagesh C., Bhavesh Vaghasiya, Mihir Sidhappara, Bhavesh Sutariya.
Maratha Mandal’s College of Pharmacy, Belgaum-590016, Karnataka
*Corresponding Author
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DOI No:
ABSTRACT:
In today’s era, various advancement has been made in research and development of oral drug delivery system. But there are some difficulties which have to be overcome in the development process. Several physiological difficulties such as the inability to restrain and localize the system within the desired region of gastrointestinal tract and the highly variable nature of the gastric emptying process have to be solved. In this review, we have summarized the general aspects of gastrointestinal tract followed by the need for gastroretentive drug delivery system. Then we have reviewed various approaches used to achieve gastric retention such as bioadhesion, expandable, high density, floating, magnetic systems and the evaluation parameters of gastroretentive dosage form. At the end, the advantages and limitations have been described.
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KEYWORDS:
Gastric emptying, Gastroretentive, Bioadhesion, Floating, Expandable, High density, magnetic
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Cite:
An Update on Gastroretentive Drug Delivery System: A review . Vivek Majethiya, Chandrashekhara S., Nagesh C., Bhavesh Vaghasiya, Mihir Sidhappara, Bhavesh Sutariya.. Research J. Pharma. Dosage Forms and Tech. 2012; 4(3): 143-152.
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