An Update on Gastroretentive Drug Delivery System: A review

Vivek Majethiya; Chandrashekhara S.; Nagesh C.; Bhavesh Vaghasiya; Mihir Sidhappara; Bhavesh Sutariya.

Research Journal of Pharmaceutical Dosage Forms and Technology

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0975-4377 (Online)
0975-234X (Print)

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An Update on Gastroretentive Drug Delivery System: A review

Author(s): Vivek Majethiya, Chandrashekhara S., Nagesh C., Bhavesh Vaghasiya, Mihir Sidhappara, Bhavesh Sutariya.

Email(s): Shekhar_bio@yahoo.co.in

DOI: Not Available

Address: Vivek Majethiya, Chandrashekhara S.*, Nagesh C., Bhavesh Vaghasiya, Mihir Sidhappara, Bhavesh Sutariya.
Maratha Mandal’s College of Pharmacy, Belgaum-590016, Karnataka
*Corresponding Author

Published In: Volume - 4, Issue - 3, Year - 2012

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ABSTRACT:
In today’s era, various advancement has been made in research and development of oral drug delivery system. But there are some difficulties which have to be overcome in the development process. Several physiological difficulties such as the inability to restrain and localize the system within the desired region of gastrointestinal tract and the highly variable nature of the gastric emptying process have to be solved. In this review, we have summarized the general aspects of gastrointestinal tract followed by the need for gastroretentive drug delivery system. Then we have reviewed various approaches used to achieve gastric retention such as bioadhesion, expandable, high density, floating, magnetic systems and the evaluation parameters of gastroretentive dosage form. At the end, the advantages and limitations have been described.

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Cite this article:
An Update on Gastroretentive Drug Delivery System: A review . Vivek Majethiya, Chandrashekhara S., Nagesh C., Bhavesh Vaghasiya, Mihir Sidhappara, Bhavesh Sutariya.. Research J. Pharma. Dosage Forms and Tech. 2012; 4(3): 143-152.

Cite(Electronic):
An Update on Gastroretentive Drug Delivery System: A review . Vivek Majethiya, Chandrashekhara S., Nagesh C., Bhavesh Vaghasiya, Mihir Sidhappara, Bhavesh Sutariya.. Research J. Pharma. Dosage Forms and Tech. 2012; 4(3): 143-152. Available on: https://rjpdft.com/AbstractView.aspx?PID=2012-4-3-2

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DOI: 10.5958/0975-4377