Formulation and Evaluation of Propranolol HCl Floating Tablets-  A Gastro Retentive Drug Delivery

Kabita Banik; Y Phalguna; B Sangeetha

doi:10.5958/0975-4377.2019.00029.6

Research Journal of Pharmaceutical Dosage Forms and Technology

ISSN

0975-4377 (Online)
0975-234X (Print)

Submit Article

Formulation and Evaluation of Propranolol HCl Floating Tablets- A Gastro Retentive Drug Delivery

Author(s): Kabita Banik, Y Phalguna, B Sangeetha

Email(s): banikkabita64@gmail.com

DOI: 10.5958/0975-4377.2019.00029.6

Address: Kabita Banik*, Dr. Y Phalguna, B Sangeetha
Bharat Institute of Technology, (BIT) Manganpally, Hyderabad, India.
*Corresponding Author

Published In: Volume - 11, Issue - 3, Year - 2019

View HTML

View PDF

ABSTRACT:
The objective of present study was to develop a gastroretentive drug delivery system of propranolol hydrochloride. The biggest problem in oral drug delivery is low and erratic drug bioavailability. This study” shown the formulation of floating tablets of Propranolol HCl by employing carbopol and HPMC as polymers. One of the disadvantages in using propranolol is extensive first pass metabolism of drug and only 25% reaches systemic circulation. The bioavailability of propranolol increases in presence of food. Also, the absorption of various drugs such as propranolol through P-glycoprotein (P-gp) efflux transporter is low and erratic. The density of P-gp increases toward the distal part of the gastrointestinal tract (GIT). Therefore, it was decided to formulate floating tablet of propranolol so that it remains in the upper part of GIT for longer time. The prepared tablets were evaluated among all the formulations (P1-P5). Formulations were evaluated for floating lag time, duration of floating, dimensional stability, drug content and in vitro drug release profile. It was observed that formulation”-5 has shown better buoyancy and dissolution profile.

Keywords:

Cite this article:
Kabita Banik, Y Phalguna, B Sangeetha. Formulation and Evaluation of Propranolol HCl Floating Tablets- A Gastro Retentive Drug Delivery. Res. J. Pharma. Dosage Forms and Tech.2019; 11(3):169-172. doi: 10.5958/0975-4377.2019.00029.6

Cite(Electronic):
Kabita Banik, Y Phalguna, B Sangeetha. Formulation and Evaluation of Propranolol HCl Floating Tablets- A Gastro Retentive Drug Delivery. Res. J. Pharma. Dosage Forms and Tech.2019; 11(3):169-172. doi: 10.5958/0975-4377.2019.00029.6 Available on: https://rjpdft.com/AbstractView.aspx?PID=2019-11-3-5

Recomonded Articles:

Factorial Designing for Pharmaceutical Product and Process Development

Author(s): Vinod K.R., Sandhya S

DOI: Access: Open Access Read More

Pharmaceutical Suspensions: Pharmacist has the Very Best Possible Formulation for the Job at Hand.

Author(s): Praneta Desale

DOI: Access: Open Access Read More

Formulation Development and Evaluation of Capsule Containing Fluclaxacillin Sodium and Amoxicillin Trihydrate with Enteric Coated Granules of Lactic Acid Bacillus

Author(s): Gopal Rao M., M. A. Amutha Gnana Arasi, S. Jayaprakash, M. Arun Kumar, P. Kavitha

DOI: Access: Open Access Read More

Formulation, Evaluation of Clotrimazole Vaginal Suppository

Author(s): V. S. Parmar, S.C. Shivhare

DOI: Access: Open Access Read More

Cleaning Validation of Paracetamol Tablets as a Dosage Formulation

Author(s): Hapse S.A., Bhagat B.V., Wagh V.S. , Kadaskar P.T.

DOI: Access: Open Access Read More

Pharmaceutical Packaging Technology: A Brief Outline

Author(s): Pratik Swarup Das, Puja Saha1, Krishan, Rumpa Das

DOI: :10.5958/0975-4377.2018.00005.8 Access: Open Access Read More

Sunflower wax as a New Natural Cosmetic Raw Material: Purification and Application in Lipsticks

Author(s): A Maru, U Pattamatta , VB Patravale

DOI: Access: Open Access Read More

A Brief Review on Intra-Uterine Drug Delivery Systems

Author(s): Suyash Ingle, Varsha Tegeli, Akshay Javalgikar, Vinod Matole, Lagmanna koli, Avinash Birajdar, Saurabh Nangare, Sagar Adlinge, Swaminath Ramanshetti, Akhil Patil, Yash Kothari, Pandurang Choure, Aaqueeb Mangalgiri, Sneha Ubale, Vaishnavi Dulange, Bhavana habib, Jyoti Mittha

DOI: 10.5958/0975-4377.2021.00013.6 Access: Open Access Read More

Transdermal Drug Delivery System of Antidiabetic Drugs: A Review

Author(s): Swapnil T. Deshpande, P. S. Vishwe, Rohit D. Shah, Swati S. Korabu, Bhakti R. Chorghe, DG Baheti

DOI: Access: Open Access Read More

Formulation and Evaluation of Stable Montelukast Sodium Sublingual Tablet by using Lyophilization Technique

Author(s): Dipti G. Phadtare, Amol R. Pawar, R.B. Saudagar, Govind K.Patil

DOI: 10.5958/0975-4377.2017.00002.7 Access: Open Access Read More

Isolation and evaluation of Basella alba linn. Leaf mucilage as release retardant in tablet formulation

Author(s): Yamunappa, Ravi Kumar, Pooja Shetty, Prathibha Suvarna, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00012.4 Access: Open Access Read More

Formulation and Evaluation of Sustained Release Matrix Tablets Containing Aceclofenac and Paracetamol

Author(s): Hamid Khan, Javed Ali

DOI: 10.5958/0975-4377.2017.00010.6 Access: Open Access Read More

Herbal mouthwash: A Review

Author(s): Shraddha Jethawa, Onkar Gopale, Suvarna Shelke

DOI: 10.52711/0975-4377.2022.00035 Access: Open Access Read More

Formulation and Evaluation of Fast Dissolving Tablets of Trimetazidine Dihydrochloride Using Natural and Synthetic Superdisintegrants

Author(s): Simila Madathil, RaviKumar, Anju Govind, Mercy Mathew, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00013.6 Access: Open Access Read More

Healing effect of Spray gel collagen extract from Channa striata bone on burn in rats

Author(s): Amallia Rachmasari, Rafidha Aisyah Kartini, Gita Alviani, Indah Solihah

DOI: 10.5958/0975-4377.2019.00046.6 Access: Open Access Read More

A Validated Method for the Estimation of EDTA in Drug Substances and their Intermediates by using Reversed Phase High Performance Liquid Chromatography

Author(s): Dharmendra Kumar Kushwah, Prakash Yashwant Kohle, Bimal Kumar Srivastava, Manoj Parmar ,Dhaval Mehta

DOI: Access: Open Access Read More

Self Microemulsifying Drug Delivery System (SMEDDS): A Novel Approach to Improve the Therapeutic Efficacy of Orally Administered Drug

Author(s): Kritika Kanoujia, Chandraprabha Dewangan, Ayushi Masih, Dipti Sinha, Divya Oraon, Manisha Jaiswal, Monika Sahu, Ranjeeta Kumari, Sapna Pradhan, Ravi Suman, Rajkishan Dewangan, Roman Banjare, Pradeep Paikra, Mukesh Rawtiya, Mukta Agrawal, Ajazuddin, D. K. Tripathi, Amit Alexander

DOI: 10.5958/0975-4377.2018.00015.0 Access: Open Access Read More

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

RNI: Not Available
DOI: 10.5958/0975-4377