Formulation and Evaluation of Buccal Tablet of Rasagiline Mesylate

Shilpa N. Shrotriya; Kishore N. Gujar; Bhakti R. Chorghe

Research Journal of Pharmaceutical Dosage Forms and Technology

ISSN

0975-4377 (Online)
0975-234X (Print)

Submit Article

Formulation and Evaluation of Buccal Tablet of Rasagiline Mesylate

Author(s): Shilpa N. Shrotriya, Kishore N. Gujar, Bhakti R. Chorghe

Email(s): bhakti03chorghe@gmail.com

DOI: Not Available

Address: Shilpa N. Shrotriya, Kishore N. Gujar, Bhakti R. Chorghe*
Department of Pharmaceutics, Sinhgad College of Pharmacy, Vadgaon (Bk.), Pune – 411 041, Maharashtra, India.
*Corresponding Author:

Published In: Volume - 5, Issue - 6, Year - 2013

View HTML

View PDF

ABSTRACT:
The objective of the present investigation was to formulate and evaluate unidirectional, bilayered, buccoadhesive tablets of rasagiline mesylate using natural excipients. Caesalpinia pulcherrima polysaccharide (CSP), Tamarind seed polysaccharide (TSP) and Locust bean gum (LBG) were used as mucoadhesive agents in the formulation. The polysaccharides were isolated and were characterized for physicochemical properties such as solubility, pH, viscosity, test for carbohydrates, flow properties, microbial load, disintegration and swelling index. Differential scanning calorimetric (DSC) studies revealed that the polysaccharides were physically compatible with drug, rasagiline mesylate (RM). The formulation F12 containing CSP (15 mg), LBG (30 mg), TSP (30 mg) demonstrated bioadhesion force of 0.3941 ± 0.01 N, residence time of 120 ± 0.3 min, % drug release of 92.81 ± 0.2% and % drug diffusion of 92.01 ± 0.01% was selected as the optimized formulation. Thus, this study suggests that CSP, TSP and LBG in combination can act as potential mucoadhesive agents for buccal delivery.

Keywords:

Cite this article:
Shilpa N. Shrotriya, Kishore N. Gujar, Bhakti R. Chorghe. Formulation and Evaluation of Buccal Tablet of Rasagiline Mesylate. Research J. Pharma. Dosage Forms and Tech. 2013; 5(6): 345-354.

Cite(Electronic):
Shilpa N. Shrotriya, Kishore N. Gujar, Bhakti R. Chorghe. Formulation and Evaluation of Buccal Tablet of Rasagiline Mesylate. Research J. Pharma. Dosage Forms and Tech. 2013; 5(6): 345-354. Available on: https://rjpdft.com/AbstractView.aspx?PID=2013-5-6-8

Recomonded Articles:

Formulation Development and Evaluation of Capsule Containing Fluclaxacillin Sodium and Amoxicillin Trihydrate with Enteric Coated Granules of Lactic Acid Bacillus

Author(s): Gopal Rao M., M. A. Amutha Gnana Arasi, S. Jayaprakash, M. Arun Kumar, P. Kavitha

DOI: Access: Open Access Read More

Isolation and evaluation of Basella alba linn. Leaf mucilage as release retardant in tablet formulation

Author(s): Yamunappa, Ravi Kumar, Pooja Shetty, Prathibha Suvarna, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00012.4 Access: Open Access Read More

Formulation and Evaluation of Fast Dissolving Tablets of Trimetazidine Dihydrochloride Using Natural and Synthetic Superdisintegrants

Author(s): Simila Madathil, RaviKumar, Anju Govind, Mercy Mathew, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00013.6 Access: Open Access Read More

Formulation and Evaluation of Transdermal Patch of Aceclofenac

Author(s): Rakesh P. Patel, Grishma Patel, Hitesh Patel , Ashok Baria

DOI: Access: Open Access Read More

Influence of Different Beverages on Disintegration Behavior of Pain Reliever Immediate Release Formulations

Author(s): Hardik B. Rana, Kajol Patel, Mansi Dholakia, Vaishali T. Thakkar, Mukesh C. Gohel, Tejal R. Gandhi

DOI: 10.5958/0975-4377.2017.00006.4 Access: Open Access Read More

Comparative Standardization of Two Marketed Preparation of Gulwel churna

Author(s): Swati Talokar, Rohan R Vakhariya, A.R Dhole

DOI: 10.5958/0975-4377.2017.00005.2 Access: Open Access Read More

Formulation and Evaluation of Telmisartan Fast Dissolving Tablets by Direct Compression Method

Author(s): Debjit Bhowmik, Rishab Bhanot, Darsh Gautam, Parshuram Rai, K.P. Sampath Kumar

DOI: 10.5958/0975-4377.2017.00022.2 Access: Open Access Read More

Formulation Development and Evaluation of Buccal Patches of Aceclofenac for Gingivitis

Author(s): Puja Saha, Pratik Swarup Das

DOI: 10.5958/0975-4377.2017.00026.X Access: Open Access Read More

Formulation and Development of Ethyl cellulose coated Pectin based Capecitabine Loaded Microspheres for Colorectal Cancer

Author(s): Dilip M. Kumbhar, Kailas K. Mali, Remeth J. Dias, Vijay D. Havaldar, Vishwajeet S. Ghorpade, Nitin H. Salunkhe.

DOI: 10.5958/0975-4377.2016.00036.7 Access: Open Access Read More

Microemulsion: A Current Review

Author(s): Sushant R. Jagtap, D.G Phadtare, R.B. Saudagar

DOI: 10.5958/0975-4377.2016.00021.5 Access: Open Access Read More

Taste Masking, Formulation and Evaluation of Orally Disintegrating Tablet of Anti-histaminic Drug

Author(s): Tejas Shah

DOI: Access: Open Access Read More

Formulation and Evaluation of Fast Dissolving Tablets containing Clopidogrel bisulfate using holy basil seeds as a natural superdisintegrant

Author(s): Omprasad Nayakal, Prajakta Patil, Mangesh Bhutkar, Dheeraj Randive, Somnath Bhinge

DOI: 10.5958/0975-4377.2018.00032.0 Access: Open Access Read More

Formulation and Optimization of Metoprolol Succinate Sublingual Tablet by Statistical Optimization Technique

Author(s): Priya Patel, NiravJani, NavinSheth, Paresh Patel

DOI: 10.5958/0975-4377.2015.00006.3 Access: Open Access Read More

Formulation and Evaluation of Immediate Release Pravastatin Sodium Tablets

Author(s): Yamunappa, Ravi Kumar, Pooja Shetty, Prathibha Suvarna, Narayana Swamy VB

DOI: 10.5958/0975-4377.2016.00014.8 Access: Open Access Read More

Glimepiride Micro balloons: A Novel Approach for Bioavailability Enhancement by Gastro-Retentive Floating Drug Delivery System

Author(s): Rutuja R. Shah, Rutuja S. Shah, Rohan R. Vakhariya

DOI: 10.5958/0975-4377.2017.00030.1 Access: Open Access Read More

A Short Review on the Formulation of Transdermal Dermal Drug Delivery System (TDDS)

Author(s): Alok Ranjan, Aishwarya Sahu, Akansha Yadav, Alka Payasi, Akash Jaiswal, Akshay Kumar, Akash Sahu, Ashwani Jangde, Chandrashekhar Nayak, Dev Kumar, Harshita Yarda, Mitali Sahu, Nokesh Sahu, Rajesh Patel, Nisha Nair, Mukta Agrawal, Ajazuddin, D. K. Tripathi, Amit Alexander

DOI: 10.5958/0975-4377.2018.00014.9 Access: Open Access Read More

Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

RNI: Not Available
DOI: 10.5958/0975-4377