Formulation and Evaluation of Buccal Tablet of Rasagiline Mesylate

Shilpa N. Shrotriya; Kishore N. Gujar; Bhakti R. Chorghe

Research Journal of Pharmaceutical Dosage Forms and Technology

ISSN

0975-4377 (Online)
0975-234X (Print)

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Formulation and Evaluation of Buccal Tablet of Rasagiline Mesylate

Author(s): Shilpa N. Shrotriya, Kishore N. Gujar, Bhakti R. Chorghe

Email(s): bhakti03chorghe@gmail.com

DOI: Not Available

Address: Shilpa N. Shrotriya, Kishore N. Gujar, Bhakti R. Chorghe*
Department of Pharmaceutics, Sinhgad College of Pharmacy, Vadgaon (Bk.), Pune – 411 041, Maharashtra, India.
*Corresponding Author:

Published In: Volume - 5, Issue - 6, Year - 2013

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ABSTRACT:
The objective of the present investigation was to formulate and evaluate unidirectional, bilayered, buccoadhesive tablets of rasagiline mesylate using natural excipients. Caesalpinia pulcherrima polysaccharide (CSP), Tamarind seed polysaccharide (TSP) and Locust bean gum (LBG) were used as mucoadhesive agents in the formulation. The polysaccharides were isolated and were characterized for physicochemical properties such as solubility, pH, viscosity, test for carbohydrates, flow properties, microbial load, disintegration and swelling index. Differential scanning calorimetric (DSC) studies revealed that the polysaccharides were physically compatible with drug, rasagiline mesylate (RM). The formulation F12 containing CSP (15 mg), LBG (30 mg), TSP (30 mg) demonstrated bioadhesion force of 0.3941 ± 0.01 N, residence time of 120 ± 0.3 min, % drug release of 92.81 ± 0.2% and % drug diffusion of 92.01 ± 0.01% was selected as the optimized formulation. Thus, this study suggests that CSP, TSP and LBG in combination can act as potential mucoadhesive agents for buccal delivery.

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Cite this article:
Shilpa N. Shrotriya, Kishore N. Gujar, Bhakti R. Chorghe. Formulation and Evaluation of Buccal Tablet of Rasagiline Mesylate. Research J. Pharma. Dosage Forms and Tech. 2013; 5(6): 345-354.

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DOI: 10.5958/0975-4377