Research Journal of Pharmaceutical Dosage Forms and Technology

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0975-4377 (Online)
0975-234X (Print)


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Formulation and Evaluation of Buccal Tablet of Rasagiline Mesylate

Author(s): Shilpa N. Shrotriya, Kishore N. Gujar, Bhakti R. Chorghe

Email(s): bhakti03chorghe@gmail.com

DOI: Not Available

Address: Shilpa N. Shrotriya, Kishore N. Gujar, Bhakti R. Chorghe*
Department of Pharmaceutics, Sinhgad College of Pharmacy, Vadgaon (Bk.), Pune – 411 041, Maharashtra, India.
*Corresponding Author:

Published In:   Volume - 5,      Issue - 6,     Year - 2013

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ABSTRACT:
The objective of the present investigation was to formulate and evaluate unidirectional, bilayered, buccoadhesive tablets of rasagiline mesylate using natural excipients. Caesalpinia pulcherrima polysaccharide (CSP), Tamarind seed polysaccharide (TSP) and Locust bean gum (LBG) were used as mucoadhesive agents in the formulation. The polysaccharides were isolated and were characterized for physicochemical properties such as solubility, pH, viscosity, test for carbohydrates, flow properties, microbial load, disintegration and swelling index. Differential scanning calorimetric (DSC) studies revealed that the polysaccharides were physically compatible with drug, rasagiline mesylate (RM). The formulation F12 containing CSP (15 mg), LBG (30 mg), TSP (30 mg) demonstrated bioadhesion force of 0.3941 ± 0.01 N, residence time of 120 ± 0.3 min, % drug release of 92.81 ± 0.2% and % drug diffusion of 92.01 ± 0.01% was selected as the optimized formulation. Thus, this study suggests that CSP, TSP and LBG in combination can act as potential mucoadhesive agents for buccal delivery.


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Cite this article:
Shilpa N. Shrotriya, Kishore N. Gujar, Bhakti R. Chorghe. Formulation and Evaluation of Buccal Tablet of Rasagiline Mesylate. Research J. Pharma. Dosage Forms and Tech. 2013; 5(6): 345-354.

Cite(Electronic):
Shilpa N. Shrotriya, Kishore N. Gujar, Bhakti R. Chorghe. Formulation and Evaluation of Buccal Tablet of Rasagiline Mesylate. Research J. Pharma. Dosage Forms and Tech. 2013; 5(6): 345-354.   Available on: https://rjpdft.com/AbstractView.aspx?PID=2013-5-6-8


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Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. ...... Read more >>>

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DOI: 10.5958/0975-4377 

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Research Journal of Pharmaceutical Dosage Forms and Technology (RJPDFT) is an international, peer-reviewed journal, devoted to pharmaceutical sciences. The aim of RJPDFT is to increase the impact of pharmaceutical research both in academia and industry, with strong emphasis on quality and originality. RJPDFT publishes Original Research Articles, Short Communications, Review Articles in all areas of pharmaceutical sciences from the discovery of a drug up to clinical evaluation. Topics covered are: Pharmaceutics and Pharmacokinetics; Pharmaceutical Chemistry, Allied sciences including drug regulatory affairs, Pharmaceutical Marketing, Pharmaceutical Microbiology, Pharmaceutical biochemistry, Pharmaceutical Education and Hospital Pharmacy.    
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