Volume No. : 5
Issue No. : 6
Year : 2013
ISSN Print : 0975-234X
ISSN Online : 0975-4377
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Shilpa N. Shrotriya, Kishore N. Gujar, Bhakti R. Chorghe*
Department of Pharmaceutics, Sinhgad College of Pharmacy, Vadgaon (Bk.), Pune – 411 041, Maharashtra, India.
*Corresponding Author:
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DOI No:
ABSTRACT:
The objective of the present investigation was to formulate and evaluate unidirectional, bilayered, buccoadhesive tablets of rasagiline mesylate using natural excipients. Caesalpinia pulcherrima polysaccharide (CSP), Tamarind seed polysaccharide (TSP) and Locust bean gum (LBG) were used as mucoadhesive agents in the formulation. The polysaccharides were isolated and were characterized for physicochemical properties such as solubility, pH, viscosity, test for carbohydrates, flow properties, microbial load, disintegration and swelling index. Differential scanning calorimetric (DSC) studies revealed that the polysaccharides were physically compatible with drug, rasagiline mesylate (RM). The formulation F12 containing CSP (15 mg), LBG (30 mg), TSP (30 mg) demonstrated bioadhesion force of 0.3941 ± 0.01 N, residence time of 120 ± 0.3 min, % drug release of 92.81 ± 0.2% and % drug diffusion of 92.01 ± 0.01% was selected as the optimized formulation. Thus, this study suggests that CSP, TSP and LBG in combination can act as potential mucoadhesive agents for buccal delivery.
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KEYWORDS:
Buccal tablet, Caesalpinia pulcherrima polysaccharide, Tamarind seed polysaccharide, Locust bean gum, Rasagiline mesylate, Mucoadhesion
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Cite:
Shilpa N. Shrotriya, Kishore N. Gujar, Bhakti R. Chorghe. Formulation and Evaluation of Buccal Tablet of Rasagiline Mesylate. Research J. Pharma. Dosage Forms and Tech. 2013; 5(6): 345-354.
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