The primary goal of treating burns that are deep and widespread and where the dermis layer has been damaged. And the natural ability of spontaneous re-epithelialization has been severely compromised or eliminated, is wound closure. Burn victims experience mental suffering because of the scarring that arises from their functional and cosmetic damage. Iodine's primary purpose in wound treatment is as an antibacterial agent. For many decades, povidone iodine has been used and studied in wound healing. Copper oxide- based wound dressings accelerate wound healing through angiogenesis, regeneration, and antibacterial qualities. With its powerful antibacterial capabilities, copper is a vital mineral that is important for many physiological and metabolic processes, including angiogenesis, skin production, expression, and stability of extracellular skin proteins. These two characteristics work together to make copper a desirable mineral for enhancing skin wellbeing. As a result, when copper oxide is added to standard items, the result is an improved product. Several compositions for Gel made of poloxamer (p188) and poloxamer(p407). Poloxamer Gels (TPGEL) are excellent thermosensitive polymers for topical application because they exist as low-viscosity liquids at ambient temperature but as Gels at body temperature.
Cite this article:
Jaydeep Singh Chauhan, Jigar Vyas. Development of Thermoreversible In-situ gel containing copper ions to cure moderate skin burns. Research Journal of Pharmaceutical Dosage Forms and Technology2023; 15(4):253-0. doi: 10.52711/0975-4377.2023.00041
Jaydeep Singh Chauhan, Jigar Vyas. Development of Thermoreversible In-situ gel containing copper ions to cure moderate skin burns. Research Journal of Pharmaceutical Dosage Forms and Technology2023; 15(4):253-0. doi: 10.52711/0975-4377.2023.00041 Available on: https://rjpdft.com/AbstractView.aspx?PID=2023-15-4-6
1. M. Madaghiele, C. Demitri, A. Sannino, L. Ambrosio, Polymeric hydrogels for burn wound care: advanced skin wound dressings and regenerative template, Burn Trauma. 2014; 2: 153–161.
2. Paul Lorenz Bigliardi, Syed Abdul Latiff Alsagoff d, Hossam Yehia El-Kafrawi e, Jai-Kyong Pyon F, Chad Tse Cheuk Wa g, Martin Anthony Villa h, Povidone iodine in wound healing: A review of current concepts and practices International Journal of Surgery. 2017; 44: 260e268.
3. C.K. Sen, S. Khanna, M. Venojarvi, P. Trikha, E.C. Ellison, T.K. Hunt, S. Roy, Am. J. Physiol. Heart Circ. 2002; 282: 1821e1827.
4. J.J. Hostynek, H.I. Maibach, Dermatol. Ther. 2004; 17: 328e333.
5. T. Tang, L. Yin, J. Yang, G. Shan. Emodin, an anthraquinone derivative from Rheum officinale Baill, enhances cutaneous wound healing in rats. Eur. J. Pharmacol. 2007; 567: 177–185. [CrossRef] [PubMed]
6. H. Qi, L. Li, C. Huang, W. Li, C. Wu. Optimization, and physicochemical characterization of thermosensitive poloxamer Gel having puerarin for ophthalmic use. Chem. Pharm. Bull. 2006; 54: 1500–1507. [CrossRef] [PubMed]
7. N.U. Okur, A. Yoltaz, V. Yozgatli, Development and characterization of Voriconazole loaded in-situ Gel formulations for ophthalmic application, Turk. J. Pharm. Sci. 2016; 13: 311–317.
8. Indian Pharmacopoeia Vol.1 The Indian Pharmacopoeia Commission, Ghaziabad, 2014; 59–66.
9. V. Jandera, D.A. Hudson, P.M. de Wet, P.M. Innes, H. Rode, Cooling the burn wound: evaluation of diﬀerent modalities, Burns. 2000; 26: 265–270.
10. K. Das, Wound healing potential of aqueous crude extract of Stevia rebaudiana in mice, Rev. Bras. Farmacogn. 2013; 23: 351–353.
11. J. Fong, F. Wood, Nanocrystalline silver dressings in wound management: a review, Int.J. Nanomedicine. 2006; 4: 441–449.